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Gene Review

SMARCAD1  -  SWI/SNF-related, matrix-associated actin...

Homo sapiens

Synonyms: ADERM, ATP-dependent helicase 1, DKFZP762K2015, DKFZp762K2015, ETL1, ...
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Disease relevance of SMARCAD1

  • To ascertain whether this new vasoconstrictor has any effect on regulation of the cerebral circulation, we measured plasma ETL-1 concentrations in patients undergoing carotid revascularization and attempted to correlate the variations of venous and arterial plasma ETL-1 with the characteristics of the procedure, including cerebral vasospasm [1].

High impact information on SMARCAD1


Biological context of SMARCAD1


Anatomical context of SMARCAD1


Associations of SMARCAD1 with chemical compounds

  • A human blood type A hemagglutinating activity was detected in albumin gland extracts of Epiphragmophora trenquelleonis snail separated by GalNAc-agarose affinity chromatography, of which two N-acetyl-D-galactosamine-binding lectins in the extracts were ETL1 was displaced from the affinity column with 1 mM GalNAc, and ETL2 with 20 mM GalNAc [8].
  • 4. We suggest that native ETL1 and ETL2 are glycoprotein complexes with molecular weights of 59-54 kDa, composed of two 29-22-kDa nonreduced protein subunits held together by noncovalent hydrophobic interactions [8].
  • By Western blot analyses developed with biotin-labeled lectins, N-linked oligosaccharides were detected in the 17- and 16-kDa protein subunits of ETL1 and ETL2, and in the 12-kDa protein subunit of ETL2 [8].

Analytical, diagnostic and therapeutic context of SMARCAD1

  • On isoelectric focusing both lectins exhibited microheterogeneity: ETL1 focused as three protein bands with pIs in the range of 5.6-6.0, while ETL2 focused as four protein bands with pIs in the range of 6.8-7 [8].
  • Gel filtration chromatography gave a native molecular weight of about 59 kDa for ETL1 and about 54 kDa for ETL2 [8].


  1. Decrease in internal jugular endothelin levels after carotid cross-clamping during human carotid revascularization procedures. Cacoub, P., Koskas, F., Timsit, S., Maistre, G., Gatel, A., Piette, J.C., Godeau, P., Carayon, A., Kieffer, E. Annals of vascular surgery. (1996) [Pubmed]
  2. Transcription initiation by RNA polymerase II does not require hydrolysis of the beta-gamma phosphoanhydride bond of ATP. Timmers, H.T. EMBO J. (1994) [Pubmed]
  3. ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3. Weber, C.A., Salazar, E.P., Stewart, S.A., Thompson, L.H. EMBO J. (1990) [Pubmed]
  4. Reovirus protein sigmaNS binds in multiple copies to single-stranded RNA and shares properties with single-stranded DNA binding proteins. Gillian, A.L., Schmechel, S.C., Livny, J., Schiff, L.A., Nibert, M.L. J. Virol. (2000) [Pubmed]
  5. Association of polymorphisms in ERCC2 gene with non-familial thyroid cancer risk. Silva, S.N., Gil, O.M., Oliveira, V.C., Cabral, M.N., Azevedo, A.P., Faber, A., Manita, I., Ferreira, T.C., Limbert, E., Pina, J.E., Rueff, J., Gaspar, J. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
  6. Casein kinase II phosphorylates bovine papillomavirus type 1 E1 in vitro at a conserved motif. McShan, G.D., Wilson, V.G. J. Gen. Virol. (1997) [Pubmed]
  7. The ATP-dependent helicase RUVBL1/TIP49a associates with tubulin during mitosis. Gartner, W., Rossbacher, J., Zierhut, B., Daneva, T., Base, W., Weissel, M., Waldhäusl, W., Pasternack, M.S., Wagner, L. Cell Motil. Cytoskeleton (2003) [Pubmed]
  8. Isolation and partial characterization of N-acetyl-D-galactosamine-binding lectins from Epiphragmophora trenquelleonis snail. Castagna, L., Zarzur, J., Filipetti, M., Landa, C. J. Biochem. (1996) [Pubmed]
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