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Chemical Compound Review

Pentosidine     (2S)-2-amino-6-[8-[[(4S)-4- amino-4-carboxy...

Synonyms: SureCN51200, AG-D-52291, CHEBI:59951, HMDB03933, CTK4B3948, ...
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Disease relevance of Pentosidine


Psychiatry related information on Pentosidine


High impact information on Pentosidine


Chemical compound and disease context of Pentosidine


Biological context of Pentosidine


Anatomical context of Pentosidine


Associations of Pentosidine with other chemical compounds


Gene context of Pentosidine


Analytical, diagnostic and therapeutic context of Pentosidine


  1. Increased collagen-linked pentosidine levels and advanced glycosylation end products in early diabetic nephropathy. Beisswenger, P.J., Moore, L.L., Brinck-Johnsen, T., Curphey, T.J. J. Clin. Invest. (1993) [Pubmed]
  2. Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus. McCance, D.R., Dyer, D.G., Dunn, J.A., Bailie, K.E., Thorpe, S.R., Baynes, J.W., Lyons, T.J. J. Clin. Invest. (1993) [Pubmed]
  3. Identification of pentosidine as a native structure for advanced glycation end products in beta-2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis. Miyata, T., Taneda, S., Kawai, R., Ueda, Y., Horiuchi, S., Hara, M., Maeda, K., Monnier, V.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  4. Maillard reaction-mediated molecular damage to extracellular matrix and other tissue proteins in diabetes, aging, and uremia. Monnier, V.M., Sell, D.R., Nagaraj, R.H., Miyata, S., Grandhee, S., Odetti, P., Ibrahim, S.A. Diabetes (1992) [Pubmed]
  5. Inhibitory effects of tenilsetam on the Maillard reaction. Shoda, H., Miyata, S., Liu, B.F., Yamada, H., Ohara, T., Suzuki, K., Oimomi, M., Kasuga, M. Endocrinology (1997) [Pubmed]
  6. Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia. Bär, K.J., Franke, S., Wenda, B., Müller, S., Kientsch-Engel, R., Stein, G., Sauer, H. Neurobiol. Aging (2003) [Pubmed]
  7. Age-related increase in an advanced glycation end product in penile tissue. Jiaan, D.B., Seftel, A.D., Fogarty, J., Hampel, N., Cruz, W., Pomerantz, J., Zuik, M., Monnier, V.M. World journal of urology. (1995) [Pubmed]
  8. Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy. Horie, K., Miyata, T., Maeda, K., Miyata, S., Sugiyama, S., Sakai, H., van Ypersole de Strihou, C., Monnier, V.M., Witztum, J.L., Kurokawa, K. J. Clin. Invest. (1997) [Pubmed]
  9. Early and advanced glycosylation end products. Kinetics of formation and clearance in peritoneal dialysis. Friedlander, M.A., Wu, Y.C., Elgawish, A., Monnier, V.M. J. Clin. Invest. (1996) [Pubmed]
  10. Mechanism of collagen network stabilization in human irreversible granulomatous liver fibrosis. Ricard-Blum, S., Bresson-Hadni, S., Guerret, S., Grenard, P., Volle, P.J., Risteli, L., Grimaud, J.A., Vuitton, D.A. Gastroenterology (1996) [Pubmed]
  11. Discordant effects of guanidines on renal structure and function and on regional vascular dysfunction and collagen changes in diabetic rats. Nyengaard, J.R., Chang, K., Berhorst, S., Reiser, K.M., Williamson, J.R., Tilton, R.G. Diabetes (1997) [Pubmed]
  12. Suppression of pentosidine formation in galactosemic rat lens by an inhibitor of aldose reductase. Nagaraj, R.H., Prabhakaram, M., Ortwerth, B.J., Monnier, V.M. Diabetes (1994) [Pubmed]
  13. Accumulation of albumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: renal implications in the pathophysiology of pentosidine. Miyata, T., Ueda, Y., Shinzato, T., Iida, Y., Tanaka, S., Kurokawa, K., van Ypersele de Strihou, C., Maeda, K. J. Am. Soc. Nephrol. (1996) [Pubmed]
  14. Plasma levels of pentosidine in diabetic patients: an advanced glycation end product. Sugiyama, S., Miyata, T., Ueda, Y., Tanaka, H., Maeda, K., Kawashima, S., Van Ypersele de Strihou, C., Kurokawa, K. J. Am. Soc. Nephrol. (1998) [Pubmed]
  15. Accumulation of Maillard reaction products in skin collagen in diabetes and aging. Dyer, D.G., Dunn, J.A., Thorpe, S.R., Bailie, K.E., Lyons, T.J., McCance, D.R., Baynes, J.W. J. Clin. Invest. (1993) [Pubmed]
  16. Chromatographic quantitation of plasma and erythrocyte pentosidine in diabetic and uremic subjects. Odetti, P., Fogarty, J., Sell, D.R., Monnier, V.M. Diabetes (1992) [Pubmed]
  17. Diabetes increases formation of advanced glycation end products on Sarco(endo)plasmic reticulum Ca2+-ATPase. Bidasee, K.R., Zhang, Y., Shao, C.H., Wang, M., Patel, K.P., Dincer, U.D., Besch, H.R. Diabetes (2004) [Pubmed]
  18. Tissue-specific effects of aldose reductase inhibition on fluorescence and cross-linking of extracellular matrix in chronic galactosemia. Relationship to pentosidine cross-links. Richard, S., Tamas, C., Sell, D.R., Monnier, V.M. Diabetes (1991) [Pubmed]
  19. Effect of collagen turnover on the accumulation of advanced glycation end products. Verzijl, N., DeGroot, J., Thorpe, S.R., Bank, R.A., Shaw, J.N., Lyons, T.J., Bijlsma, J.W., Lafeber, F.P., Baynes, J.W., TeKoppele, J.M. J. Biol. Chem. (2000) [Pubmed]
  20. Evidence of a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen. Nagaraj, R.H., Kern, T.S., Sell, D.R., Fogarty, J., Engerman, R.L., Monnier, V.M. Diabetes (1996) [Pubmed]
  21. Structure and mechanism of formation of human lens fluorophore LM-1. Relationship to vesperlysine A and the advanced Maillard reaction in aging, diabetes, and cataractogenesis. Tessier, F., Obrenovich, M., Monnier, V.M. J. Biol. Chem. (1999) [Pubmed]
  22. Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors. Grandhee, S.K., Monnier, V.M. J. Biol. Chem. (1991) [Pubmed]
  23. Quantitative analysis of crosslinks pyridinoline and pentosidine in articular cartilage of patients with bone and joint disorders. Takahashi, M., Kushida, K., Ohishi, T., Kawana, K., Hoshino, H., Uchiyama, A., Inoue, T. Arthritis Rheum. (1994) [Pubmed]
  24. Vascular proliferation and enhanced expression of endothelial nitric oxide synthase in human peritoneum exposed to long-term peritoneal dialysis. Combet, S., Miyata, T., Moulin, P., Pouthier, D., Goffin, E., Devuyst, O. J. Am. Soc. Nephrol. (2000) [Pubmed]
  25. Increased pentosidine, an advanced glycation end product, in serum and synovial fluid from patients with knee osteoarthritis and its relation with cartilage oligomeric matrix protein. Senolt, L., Braun, M., Olejárová, M., Forejtová, S., Gatterová, J., Pavelka, K. Ann. Rheum. Dis. (2005) [Pubmed]
  26. Enhanced RAGE-mediated NFkappaB stimulation in inflamed hemodialysis patients. Rodríguez-Ayala, E., Anderstam, B., Suliman, M.E., Seeberger, A., Heimbürger, O., Lindholm, B., Stenvinkel, P. Atherosclerosis (2005) [Pubmed]
  27. Increased pentosidine, an advanced glycation end product, in plasma and synovial fluid from patients with rheumatoid arthritis and its relation with inflammatory markers. Miyata, T., Ishiguro, N., Yasuda, Y., Ito, T., Nangaku, M., Iwata, H., Kurokawa, K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  28. Anti-hypertensive agents inhibit in vivo the formation of advanced glycation end products and improve renal damage in a type 2 diabetic nephropathy rat model. Nangaku, M., Miyata, T., Sada, T., Mizuno, M., Inagi, R., Ueda, Y., Ishikawa, N., Yuzawa, H., Koike, H., van Ypersele de Strihou, C., Kurokawa, K. J. Am. Soc. Nephrol. (2003) [Pubmed]
  29. ELISA of pentosidine, an advanced glycation end product, in biological specimens. Taneda, S., Monnier, V.M. Clin. Chem. (1994) [Pubmed]
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