The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

BAGE  -  B melanoma antigen

Homo sapiens

Synonyms: Antigen MZ2-BA, B melanoma antigen 1, BAGE1, CT2.1, Cancer/testis antigen 2.1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of BAGE


High impact information on BAGE

  • Some of these antigens are encoded by genes MAGE-1, MAGE-3, and BAGE, which are expressed in a large fraction of tumors of various histological types but are silent in normal adult tissues with the exception of testis [4].
  • Human genes expressed exclusively in tumors and male germ line cells, such as those of the MAGE, BAGE, and GAGE families, encode antigens recognized by T lymphocytes, which are potentially useful for antitumor immunotherapy [5].
  • Of 11 cell lines, BAGE, GAGE1-6, GAGE1-2, MAGE-1, and MAGE-3 were detected in 7 (64%), 4 (36%), 3 (27%), 8 (73%), and 8 (73%) cell lines, respectively [6].
  • An analysis of the relationship between clinicopathological factors and the expression of these genes revealed that either BAGE or one of these genes was more frequently expressed in histologically intestinal-type than in diffuse-type carcinomas [6].
  • Also, DNA from testes and sperm was hypomethylated in at least one of the BAGE loci [7].

Biological context of BAGE


Anatomical context of BAGE


Associations of BAGE with chemical compounds

  • In addition, the frequency of expression of more recently discovered tumour antigens (BAGE, GAGE -1, -2 and GAGE -3, -6) was established using RT-PCR and ethidium bromide staining [13].

Other interactions of BAGE

  • The duplicated region contained a fragment of the MLL3 gene, which, after juxtacentromeric reshuffling, generated the ancestral BAGE gene [8].
  • CONCLUSION: These data suggest that immunotherapy of bladder cancer could target CTAs, especially those expressed at higher frequency such as MAGE-A, BAGE and NY-ESO-1/LAGE-1 [14].
  • MAGE-A, BAGE and NY-ESO-1/LAGE-1 mRNAs were the most frequently detected, respectively in 5677%, 212% and 89% of superficial and in 6461%, 4139% and 276% of invasive tumours [14].

Analytical, diagnostic and therapeutic context of BAGE

  • Because of its tumor-specific expression, the BAGE-encoded antigen may prove useful for cancer immunotherapy [1].


  1. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. Boël, P., Wildmann, C., Sensi, M.L., Brasseur, R., Renauld, J.C., Coulie, P., Boon, T., van der Bruggen, P. Immunity (1995) [Pubmed]
  2. New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. Ruault, M., van der Bruggen, P., Brun, M.E., Boyle, S., Roizès, G., De Sario, A. Eur. J. Hum. Genet. (2002) [Pubmed]
  3. mRNA detection of tumor-rejection genes BAGE, GAGE, and MAGE in peritoneal fluid from patients with ovarian carcinoma as a potential diagnostic tool. Hofmann, M., Ruschenburg, I. Cancer (2002) [Pubmed]
  4. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. Van den Eynde, B., Peeters, O., De Backer, O., Gaugler, B., Lucas, S., Boon, T. J. Exp. Med. (1995) [Pubmed]
  5. Identification of a new MAGE gene with tumor-specific expression by representational difference analysis. Lucas, S., De Smet, C., Arden, K.C., Viars, C.S., Lethé, B., Lurquin, C., Boon, T. Cancer Res. (1998) [Pubmed]
  6. Expression of BAGE, GAGE, and MAGE genes in human gastric carcinoma. Li, J., Yang, Y., Fujie, T., Baba, K., Ueo, H., Mori, M., Akiyoshi, T. Clin. Cancer Res. (1996) [Pubmed]
  7. Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. Grunau, C., Sanchez, C., Ehrlich, M., van der Bruggen, P., Hindermann, W., Rodriguez, C., Krieger, S., Dubeau, L., Fiala, E., De Sario, A. Genes Chromosomes Cancer (2005) [Pubmed]
  8. BAGE genes generated by juxtacentromeric reshuffling in the Hominidae lineage are under selective pressure. Ruault, M., Ventura, M., Galtier, N., Brun, M.E., Archidiacono, N., Roizès, G., De Sario, A. Genomics (2003) [Pubmed]
  9. MAGE, BAGE and GAGE gene expression in human rhabdomyosarcomas. Dalerba, P., Frascella, E., Macino, B., Mandruzzato, S., Zambon, A., Rosolen, A., Carli, M., Ninfo, V., Zanovello, P. Int. J. Cancer (2001) [Pubmed]
  10. Expression of A, G and B melanoma antigen genes in human hepatocellular carcinoma. Chen, Z., Shao, J.B., Wu, W. HBPD INT (2002) [Pubmed]
  11. Expression of MAGE, GAGE and BAGE genes in human liver diseases: utility as molecular markers for hepatocellular carcinoma. Kobayashi, Y., Higashi, T., Nouso, K., Nakatsukasa, H., Ishizaki, M., Kaneyoshi, T., Toshikuni, N., Kariyama, K., Nakayama, E., Tsuji, T. J. Hepatol. (2000) [Pubmed]
  12. MAGE, BAGE, and GAGE gene expression in patients with esophageal squamous cell carcinoma and adenocarcinoma of the gastric cardia. Zambon, A., Mandruzzato, S., Parenti, A., Macino, B., Dalerba, P., Ruol, A., Merigliano, S., Zaninotto, G., Zanovello, P. Cancer (2001) [Pubmed]
  13. MAGE, BAGE and GAGE: tumour antigen expression in benign and malignant ovarian tissue. Gillespie, A.M., Rodgers, S., Wilson, A.P., Tidy, J., Rees, R.C., Coleman, R.E., Murray, A.K. Br. J. Cancer (1998) [Pubmed]
  14. Cancer-testis antigen expression in bladder cancer. Fradet, Y., Picard, V., Bergeron, A., LaRue, H. Prog. Urol. (2005) [Pubmed]
WikiGenes - Universities