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Gene Review

INTS2  -  integrator complex subunit 2

Homo sapiens

Synonyms: INT2, Int2, Integrator complex subunit 2, KIAA1287
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Disease relevance of INTS2


Psychiatry related information on INTS2


High impact information on INTS2

  • The International Prognostic Scoring System (IPSS) groups Low/Intermediate-1 (Low/Int-1) had longer response duration than Int-2/High (25 versus 7 months, P = .002) [7].
  • Int-2/hst-1 coamplification greater than 3-fold was observed in the primary tumors of 30 of 107 cases (28%), and in the metastatic lymph nodes of 12 of 40 cases (30%) [1].
  • Int-2 allelic imbalance was shown to be an early event in carcinoid tumor formation by virtue of the absence of allelic imbalance for other common cancer-related gene disturbances involving 11p13 (Wilms' tumor), 3p25 (von-Hippel-Lindau), and 17p13 (p53) [3].
  • Of 21 cases of metastatic invasive cancer, 43% had Myc, 43% had Neu, and 40% had Int-2 gene amplification [2].
  • The high incidence of Int-2 amplifications strongly suggests a role of this proto-oncogene in the pathogenesis of NPC [8].

Biological context of INTS2


Anatomical context of INTS2


Associations of INTS2 with chemical compounds

  • Int-2/FGF3 gene amplications were good indicators of prognosis, especially in premenopausal patients, and also in lymph-node-positive and steroid-receptor-negative patients [12].

Other interactions of INTS2


  1. Significance of int-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma. Kitagawa, Y., Ueda, M., Ando, N., Shinozawa, Y., Shimizu, N., Abe, O. Cancer Res. (1991) [Pubmed]
  2. Oncogene amplification in breast cancer. Donovan-Peluso, M., Contento, A.M., Tobon, H., Ripepi, B., Locker, J. Am. J. Pathol. (1991) [Pubmed]
  3. 11q13 allelic imbalance discriminates pulmonary carcinoids from tumorlets. A microdissection-based genotyping approach useful in clinical practice. Finkelstein, S.D., Hasegawa, T., Colby, T., Yousem, S.A. Am. J. Pathol. (1999) [Pubmed]
  4. Chromosomal deletions and K-ras gene mutations in human endometrial carcinomas. Imamura, T., Arima, T., Kato, H., Miyamoto, S., Sasazuki, T., Wake, N. Int. J. Cancer (1992) [Pubmed]
  5. First hints for a correlation between amplification of the Int-2 gene and infection with human papillomavirus in head and neck squamous cell carcinomas. Kleist, B., Poetsch, M., Bankau, A., Werner, E., Herrmann, F.H., Lorenz, G. J. Oral Pathol. Med. (2000) [Pubmed]
  6. Functional roles and circuitry in an inhibitory pathway to feeding command neurones in Pleurobranchaea. London, J.A., Gillette, R. J. Exp. Biol. (1984) [Pubmed]
  7. Long-term outcome of treatment of anemia in MDS with erythropoietin and G-CSF. Jädersten, M., Montgomery, S.M., Dybedal, I., Porwit-MacDonald, A., Hellström-Lindberg, E. Blood (2005) [Pubmed]
  8. Frequent c-myc and Int-2 overrepresentations in nasopharyngeal carcinoma. Fan, C.S., Wong, N., Leung, S.F., To, K.F., Lo, K.W., Lee, S.W., Mok, T.S., Johnson, P.J., Huang, D.P. Hum. Pathol. (2000) [Pubmed]
  9. Amplification of the Int-2 gene in head and neck squamous cell carcinoma. Rubin, J.S., Qiu, L., Etkind, P. The Journal of laryngology and otology. (1995) [Pubmed]
  10. Advances in histological methods open up new perspectives for craniofacial growth research. Thesleff, I., Vaahtokari, A., Vainio, S. Proceedings of the Finnish Dental Society. Suomen Hammaslääkäriseuran toimituksia. (1991) [Pubmed]
  11. Minimal expression of the proto-oncogene int-2 encoded protein in a series of colorectal carcinomas. Papanikolaou, I.S., Lazaris, A.C., Kavantzas, N., Davaris, P.S. J. Gastroenterol. Hepatol. (2002) [Pubmed]
  12. Int-2/FGF3 amplification is a better independent predictor of relapse than c-myc and c-erbB-2/neu amplifications in primary human breast cancer. Champème, M.H., Bièche, I., Hacène, K., Lidereau, R. Mod. Pathol. (1994) [Pubmed]
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