Disease relevance of INTS1

• Nontypeable Haemophilus influenzae strain INT1 was isolated from the blood of a young child with clinical signs of meningitis following acute otitis media [1].
• We used a subtractive phage display approach to affinity select for peptides binding to the cell surface of a novel invasive NTHi strain R2866 (also called Int1) [2].
• Nevertheless, INT1 established bacteremia and meningitis in infant and weanling rat models of invasive H. influenzae infection [1].
• RAEB patients (53) were distributed predominantly between INT-1-risk and INT-2-risk groups, RAEB-t patients (23) between INT-2-risk and high-risk subgroups [3].
• Our findings indicate that INT1 amplification may be a feature of increased malignant potential in retinoblastomas [4].

Psychiatry related information on INTS1

• The Int-1 population is phasically active during the rhythmic motor activity that underlies feeding [5].
• However, the response latencies and directional sensitivity of only LBN-ei suggest that it is directly connected to Int-1 [6].
• Three different stimulation intensities were applied: threefold sensory threshold (INT 1), motor plus sensory threshold (INT 2), individual level of tolerance (INT 3) [7].

High impact information on INTS1

• The International Prognostic Scoring System (IPSS) groups Low/Intermediate-1 (Low/Int-1) had longer response duration than Int-2/High (25 versus 7 months, P = .002) [8].
• The frequency selectivity of the identified auditory interneuron, Int-1, in the cricket Teleogryllus oceanicus was examined using intracellular recording and staining techniques [9].
• Int-1 was excited by frequencies between 3 and 40 kHz, being similar, therefore, to the tympal organ (ear) in its broad range sensitivity; however, it responded differentially to high and low frequencies in terms of the number of action potentials evoked per stimulus tone pulse, the average discharge rate, and the latency of response [9].
• Wnt-2 is a member of the Wnt gene family that includes the proto-oncogene Wnt-1 (formerly Int-1) [10].
• Ints alpha(5)beta(1) and alpha(v)beta(6) mediated adhesion to Fn and Int alpha(v)beta(5) mediated adhesion to Vn, and both were inhibited by RGD peptide [11].

Biological context of INTS1

• Sensitive ELISA proved the absence of intra- or extracellular capsular polysaccharide production by INT1 and Southern blot analysis confirmed the lack of an intact capsulation (cap) gene locus within the chromosome [1].
• High-molecular-weight DNA isolated from INT1 was shown to confer an invasive phenotype on transformation of a nonencapsulated, avirulent laboratory strain of H. influenzae [1].
• INT1 is a putative oncogene that has been localized to the chromosome band 12q13 [12].
• We present theoretical and experimental data that indicate that the period of the MCN1 activated gastric mill rhythm depends on the strength and time course of the MCN1 evoked slow excitatory synaptic potential (EPSP) in the LG neuron, and on the strength of inhibition of Int 1 by the pacemaker of the pyloric network [13].
• Transfer of antimicrobial resistance (ampicillin, streptomycin and sulphonamides), the tem-1 gene and markers (int1, qacEDelta1, sul1) characteristic of class 1 integrons were evident in one MDR isolate (resistant to 4 antimicrobial classes) when conjugation and transformation experiments were performed [14].

Anatomical context of INTS1

• Disruption of KIAA1440 led to embryonic lethality at the blastocyst stage [15].

Other interactions of INTS1

• In small subsets of Low/Int-1-risk patients with MDS, hematopoietic cytokines or antithymocyte globulin may reduce transfusion requirements [16].

References