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Gene Review

WDR19  -  WD repeat domain 19

Homo sapiens

Synonyms: ATD5, CED4, DYF-2, FLJ23127, IFT144, ...
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Disease relevance of WDR19

  • The HHV-8 ORF 26 sequences, ten of which were unique, could be segregated into four groups according to peptide motifs [1].
  • Five proteins from the chloroeremomycin biosynthetic cluster, ORF14 and ORF23 to ORF26, have been expressed heterologously in Escherichia coli and purified to near homogeneity, and each has been characterized for an enzymatic activity [2].
  • To investigate the expression of human herpesvirus 8 (HHV8)-encoded proteins in the cells of primary effusion lymphoma (PEL), Kaposi's sarcoma (KS) and multicentric Castleman's disease (MCD), nine rabbit polyclonal antibodies to K2, ORF26, K8, K8.1, K10, K11, ORF59, ORF65, and ORF73 were developed [3].
  • Because of similarities in the pathophysiology of multiple myeloma and Waldenstrom's macroglobulinaemia (WM), we investigated DNA samples from 20 bone marrow biopsies with WM for the detection of KSHV by PCR (KS330/ORF26) [4].
  • WDR19 should be added to the list of prostate cancer tissue markers [5].

High impact information on WDR19

  • FINDINGS: HHV-8 ORF 26 DNA was detected in significantly higher proportions of sarcoid than of non-sarcoid tissue samples from lung (8/8 vs 0/54; p < 0.0001), lymph nodes (26/27 vs 6/29; p < 0.0001), skin (2/2 vs 0/17; p = 0.006), and oral tissues (2/2 vs 1/13; p = 0.029) [1].
  • Detection of HHV-8 DNA was performed using three different N-PCR, targeting nonoverlapping regions in open reading frame (ORF) 25 and ORF26 [6].
  • Sequencing of amplicons showed a homogeneous restricted variability in the ORF26 region, characteristic of the minority subgroup B defined by Zong, and responsible for isoleucine and glycine substitutions at amino acid positions 134 and 167 [6].
  • ORF26 sequence data suggest that MM patients are consistently carriers of HHV-8 strain subtype C3 [7].
  • Sequence variation was sought in 3 loci of the HHV-8 genome: the internal repeat domain of open-reading frame (ORF) 73, the KS330 segment of ORF 26, and variable region 1 of ORF K1 [8].

Chemical compound and disease context of WDR19


Biological context of WDR19

  • WDR19 transcripts exhibit alternative splicing in which two isoforms appear to be prostate restricted, a property that could be exploited for designing diagnostic or therapeutic strategies for prostate carcinoma [10].
  • The WDR19 gene comprises 36 exons and is located on chromosome 4p15-4p11 [10].
  • Polymerase chain reaction for HHV-8 DNA was performed on PBMC and subpopulations with a primer pair selected from ORF26 of the viral genome [11].
  • Since sensitive PCR of ORF26 allowed us to analyze the SNPs by using peripheral blood from HHV-8-infected patients, the ORF26 SNPs will be a potent tool for investigating the pathogenesis of HHV-8 infection [12].
  • The threshold for PCR test sensitivity with the help of serial dilution of DNA was at the level of five plasmid ORF-26 regions, and DNA from 25 body cavity-based lymphoma-1 cells [13].

Anatomical context of WDR19


Associations of WDR19 with chemical compounds

  • Most of the samples were shown to be subtype A3, however, subtypes A, B3/C2/C2', and C3 (ORF 26 region) were also identified [15].
  • Analysis of the KS330 region within ORF-26 revealed that the HHV8 strains were distributed to the C1, C3 or A1 subtypes [16].

Analytical, diagnostic and therapeutic context of WDR19


  1. Human herpesvirus 8 variants in sarcoid tissues. Di Alberti, L., Piattelli, A., Artese, L., Favia, G., Patel, S., Saunders, N., Porter, S.R., Scully, C.M., Ngui, S.L., Teo, C.G. Lancet (1997) [Pubmed]
  2. Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis. Chen, H., Thomas, M.G., Hubbard, B.K., Losey, H.C., Walsh, C.T., Burkart, M.D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease. Katano, H., Sato, Y., Kurata, T., Mori, S., Sata, T. Virology (2000) [Pubmed]
  4. Kaposi's sarcoma-associated herpesvirus (KSHV) in bone marrow biopsies of patients with Waldenstrom's macroglobulinaemia. Brousset, P., Theriault, C., Roda, D., Attal, M., Delsol, G. Br. J. Haematol. (1998) [Pubmed]
  5. WDR19 expression is increased in prostate cancer compared with normal cells, but low-intensity expression in cancers is associated with shorter time to biochemical failures and local recurrence. Lin, B., Utleg, A.G., Gravdal, K., White, J.T., Halvorsen, O.J., Lu, W., True, L.D., Vessella, R., Lange, P.H., Nelson, P.S., Hood, L., Kalland, K.H., Akslen, L.A. Clin. Cancer Res. (2008) [Pubmed]
  6. Human herpesvirus 8 infection in patients with POEMS syndrome-associated multicentric Castleman's disease. Bélec, L., Mohamed, A.S., Authier, F.J., Hallouin, M.C., Soe, A.M., Cotigny, S., Gaulard, P., Gherardi, R.K. Blood (1999) [Pubmed]
  7. Human herpesvirus 8 open reading frame 26 and open reading frame 65 sequences from multiple myeloma patients: a shared pattern not found in Kaposi's sarcoma or primary effusion lymphoma. Ma, H.J., Sjak-Shie, N.N., Vescio, R.A., Kaminsky, M., Mikail, A., Pold, M., Parker, K., Beksac, M., Belson, D., Moss, T.J., Wu, C.H., Zhou, J., Zhang, L., Chen, G., Said, J.W., Berenson, J.R. Clin. Cancer Res. (2000) [Pubmed]
  8. Multiple human herpesvirus-8 infection. Beyari, M.M., Hodgson, T.A., Cook, R.D., Kondowe, W., Molyneux, E.M., Scully, C.M., Teo, C.G., Porter, S.R. J. Infect. Dis. (2003) [Pubmed]
  9. HHV-8 subtypes in South Africa: identification of a case suggesting a novel B variant. Treurnicht, F.K., Engelbrecht, S., Taylor, M.B., Schneider, J.W., van Rensburg, E.J. J. Med. Virol. (2002) [Pubmed]
  10. Isolation and characterization of human and mouse WDR19,a novel WD-repeat protein exhibiting androgen-regulated expression in prostate epithelium. Lin, B., White, J.T., Utleg, A.G., Wang, S., Ferguson, C., True, L.D., Vessella, R., Hood, L., Nelson, P.S. Genomics (2003) [Pubmed]
  11. Infection of circulating CD34+ cells by HHV-8 in patients with Kaposi's sarcoma. Henry, M., Uthman, A., Geusau, A., Rieger, A., Furci, L., Lazzarin, A., Lusso, P., Tschachler, E. J. Invest. Dermatol. (1999) [Pubmed]
  12. Molecular analysis of human herpesvirus 8 by using single nucleotide polymorphisms in open reading frame 26. Endo, T., Miura, T., Koibuchi, T., Nakamura, H., Takahashi, T., Odawara, T., Goto, M., Ajisawa, A., Iwamoto, A., Nakamura, T. J. Clin. Microbiol. (2003) [Pubmed]
  13. HHV-8/KSHV during the development of Kaposi's sarcoma: evaluation by polymerase chain reaction and immunohistochemistry. Pak, F., Pyakural, P., Kokhaei, P., Kaaya, E., Pourfathollah, A.A., Selivanova, G., Biberfeld, P. J. Cutan. Pathol. (2005) [Pubmed]
  14. Viral load of human herpesvirus 8 (HHV-8) in the circulatory blood cells correlates with clinical progression in a patient with HHV-8-associated solid lymphoma with aids-associated Kaposi's sarcoma. Song, J., Yoshida, A., Yamamoto, Y., Katano, H., Hagihara, K., Oka, S., Kimura, S., Yoshizaki, K. Leuk. Lymphoma (2004) [Pubmed]
  15. Genotypic distribution of human herpesvirus-8 strains circulating in HIV-positive patients with and without Kaposi's sarcoma in Hungary. Szalai, E., Takács, M., Otvös, R., Szlávik, J., Juhász, A., Berencsi, G. Arch. Virol. (2005) [Pubmed]
  16. Prevalence of human herpesvirus 8 DNA sequences in human immunodeficiency virus-negative individuals without Kaposi's sarcoma in Greece. Zavos, G., Gazouli, M., Papaconstantinou, I., Lukas, J.C., Zografidis, A., Kostakis, A., Nasioulas, G. In Vivo (2005) [Pubmed]
  17. Open reading frame 26 of human herpesvirus 8 encodes a tetradecanoyl phorbol acetate- and butyrate-inducible 32-kilodalton protein expressed in a body cavity-based lymphoma cell line. O'Neill, E., Douglas, J.L., Chien, M.L., Garcia, J.V. J. Virol. (1997) [Pubmed]
  18. Detection and genetic polymorphism of human herpes virus type 8 in endemic or epidemic Kaposi's sarcoma from West and Central Africa, and South America. Fouchard, N., Lacoste, V., Couppie, P., Develoux, M., Mauclere, P., Michel, P., Herve, V., Pradinaud, R., Bestetti, G., Huerre, M., Tekaia, F., de Thé, G., Gessain, A. Int. J. Cancer (2000) [Pubmed]
  19. Human herpesvirus 8 reactivation and human immunodeficiency virus type 1 gp120. Lu, C., Gordon, G.M., Chandran, B., Nickoloff, B.J., Foreman, K.E. Arch. Pathol. Lab. Med. (2002) [Pubmed]
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