Gene Review:
ELAC2 - elaC ribonuclease Z 2
Homo sapiens
Synonyms:
COXPD17, ELC2, ElaC homolog protein 2, FLJ10530, HPC2, ...
Takahashi,
Lu,
Watanabe,
Katoh,
Furusato,
Tsukino,
Nakao,
Sudo,
Suzuki,
Akakura,
Ikemoto,
Asano,
Ito,
Wakui,
Muto,
Hano,
Simard,
Dumont,
Soucy,
Labrie,
Lange,
Gillanders,
Davis,
Brown,
Campbell,
Jones,
Gildea,
Riedesel,
Albertus,
Freas-Lutz,
Markey,
Giri,
Dimmer,
Montie,
Trent,
Cooney,
Zamboni,
Jung,
Egorin,
Hamburger,
Joseph,
Jin,
Strychor,
Ramanathan,
Eiseman,
Rökman,
Ikonen,
Mononen,
Autio,
Matikainen,
Koivisto,
Tammela,
Kallioniemi,
Schleutker,
Stanford,
Sabacan,
Noonan,
Iwasaki,
Shu,
Feng,
Ostrander,
Rebbeck,
Walker,
Zeigler-Johnson,
Weisburg,
Martin,
Nathanson,
Wein,
Malkowicz,
- ELAC2/HPC2 involvement in hereditary and sporadic prostate cancer. Rökman, A., Ikonen, T., Mononen, N., Autio, V., Matikainen, M.P., Koivisto, P.A., Tammela, T.L., Kallioniemi, O.P., Schleutker, J. Cancer Res. (2001)
- A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease. Takaku, H., Minagawa, A., Takagi, M., Nashimoto, M. Nucleic Acids Res. (2003)
- Relationship between plasma exposure of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite and antitumor response in mice bearing human colon carcinoma xenografts. Zamboni, W.C., Jung, L.L., Egorin, M.J., Hamburger, D.R., Joseph, E., Jin, R., Strychor, S., Ramanathan, R.K., Eiseman, J.L. Clin. Cancer Res. (2005)
- Meta-analysis of associations of the Ser217Leu and Ala541Thr variants in ELAC2 (HPC2) and prostate cancer. Camp, N.J., Tavtigian, S.V. Am. J. Hum. Genet. (2002)
- Evaluation of linkage and association of HPC2/ELAC2 in patients with familial or sporadic prostate cancer. Xu, J., Zheng, S.L., Carpten, J.D., Nupponen, N.N., Robbins, C.M., Mestre, J., Moses, T.Y., Faith, D.A., Kelly, B.D., Isaacs, S.D., Wiley, K.E., Ewing, C.M., Bujnovszky, P., Chang , B., Bailey-Wilson, J., Bleecker, E.R., Walsh, P.C., Trent, J.M., Meyers, D.A., Isaacs, W.B. Am. J. Hum. Genet. (2001)
- Association of HPC2/ELAC2 genotypes and prostate cancer. Rebbeck, T.R., Walker, A.H., Zeigler-Johnson, C., Weisburg, S., Martin, A.M., Nathanson, K.L., Wein, A.J., Malkowicz, S.B. Am. J. Hum. Genet. (2000)
- Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins. Sewalt, R.G., Lachner, M., Vargas, M., Hamer, K.M., den Blaauwen, J.L., Hendrix, T., Melcher, M., Schweizer, D., Jenuwein, T., Otte, A.P. Mol. Cell. Biol. (2002)
- Role of HPC2/ELAC2 in hereditary prostate cancer. Wang, L., McDonnell, S.K., Elkins, D.A., Slager, S.L., Christensen, E., Marks, A.F., Cunningham, J.M., Peterson, B.J., Jacobsen, S.J., Cerhan, J.R., Blute, M.L., Schaid, D.J., Thibodeau, S.N. Cancer Res. (2001)
- Association of common missense changes in ELAC2 ( HPC2) with prostate cancer in a Japanese case-control series. Fujiwara, H., Emi, M., Nagai, H., Nishimura, T., Konishi, N., Kubota, Y., Ichikawa, T., Takahashi, S., Shuin, T., Habuchi, T., Ogawa, O., Inoue, K., Skolnick, M.H., Swensen, J., Camp, N.J., Tavtigian, S.V. J. Hum. Genet. (2002)
- Polymorphisms in the prostate cancer susceptibility gene HPC2/ELAC2 in multiplex families and healthy controls. Suarez, B.K., Gerhard, D.S., Lin, J., Haberer, B., Nguyen, L., Kesterson, N.K., Catalona, W.J. Cancer Res. (2001)
- Perspective: prostate cancer susceptibility genes. Simard, J., Dumont, M., Soucy, P., Labrie, F. Endocrinology (2002)
- Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan prostate cancer genetics project finds evidence for linkage on chromosome 17 near BRCA1. Lange, E.M., Gillanders, E.M., Davis, C.C., Brown, W.M., Campbell, J.K., Jones, M., Gildea, D., Riedesel, E., Albertus, J., Freas-Lutz, D., Markey, C., Giri, V., Dimmer, J.B., Montie, J.E., Trent, J.M., Cooney, K.A. Prostate (2003)
- Association of hereditary prostate cancer gene polymorphic variants with sporadic aggressive prostate carcinoma. Noonan-Wheeler, F.C., Wu, W., Roehl, K.A., Klim, A., Haugen, J., Suarez, B.K., Kibel, A.S. Prostate (2006)
- Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2. Dumont, M., Frank, D., Moisan, A.M., Tranchant, M., Soucy, P., Breton, R., Labrie, F., Tavtigian, S.V., Simard, J. Biochim. Biophys. Acta (2004)
- ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells. Noda, D., Itoh, S., Watanabe, Y., Inamitsu, M., Dennler, S., Itoh, F., Koike, S., Danielpour, D., Ten Dijke, P., Kato, M. Oncogene (2006)
- The product of the candidate prostate cancer susceptibility gene ELAC2 interacts with the gamma-tubulin complex. Korver, W., Guevara, C., Chen, Y., Neuteboom, S., Bookstein, R., Tavtigian, S., Lees, E. Int. J. Cancer (2003)
- Association of HPC2/ELAC2 polymorphisms with risk of prostate cancer in a population-based study. Stanford, J.L., Sabacan, L.P., Noonan, E.A., Iwasaki, L., Shu, J., Feng, Z., Ostrander, E.A. Cancer Epidemiol. Biomarkers Prev. (2003)
- Loss of heterozygosity of the putative prostate cancer susceptibility gene HPC2/ELAC2 is uncommon in sporadic and familial prostate cancer. Wu, Y.Q., Chen, H., Rubin, M.A., Wojno, K.J., Cooney, K.A. Cancer Res. (2001)
- Ser217Leu polymorphism of the HPC2/ELAC2 gene associated with prostatic cancer risk in Japanese men. Takahashi, H., Lu, W., Watanabe, M., Katoh, T., Furusato, M., Tsukino, H., Nakao, H., Sudo, A., Suzuki, H., Akakura, K., Ikemoto, I., Asano, K., Ito, T., Wakui, S., Muto, T., Hano, H. Int. J. Cancer (2003)
- A panel of monoclonal antibodies against human polycomb group proteins. Hamer, K.M., Sewalt, R.G., den Blaauwen, J.L., Hendrix, T., Satijn, D.P., Otte, A.P. Hybrid. Hybridomics (2002)
- The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2. Qin, H., Du, D., Zhu, Y., Li, J., Feng, L., Liang, Y., Han, H. FEBS Lett. (2005)