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Gene Review

RGS18  -  regulator of G-protein signaling 18

Homo sapiens

Synonyms: RGS13, Regulator of G-protein signaling 18
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Disease relevance of RGS18


High impact information on RGS18

  • We found that RGS16 and RGS18 mRNA expression was up-regulated during this process [2].
  • Phosphorylation of RGS18 was mapped to Ser49 by MS/MS analysis [3].
  • Although various subcellular localizations of RGS have been reported, RGS18 was found to be localized in cytoplasm in megakaryocytes [4].
  • Although GC T cells express high levels of CXCR4, signaling through this receptor appears to be specifically inhibited by FDC-mediated expression of RGS13 and RGS16 [5].
  • Furthermore, FDCs up-regulated both RGS13 and RGS16 mRNA expression in non-GC T cells, resulting in their impaired migration to CXCL12 [5].

Biological context of RGS18


Anatomical context of RGS18


  1. RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. Han, J.I., Huang, N.N., Kim, D.U., Kehrl, J.H. J. Leukoc. Biol. (2006) [Pubmed]
  2. RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes. Berthebaud, M., Rivière, C., Jarrier, P., Foudi, A., Zhang, Y., Compagno, D., Galy, A., Vainchenker, W., Louache, F. Blood (2005) [Pubmed]
  3. Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. García, A., Prabhakar, S., Hughan, S., Anderson, T.W., Brock, C.J., Pearce, A.C., Dwek, R.A., Watson, S.P., Hebestreit, H.F., Zitzmann, N. Blood (2004) [Pubmed]
  4. A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Nagata, Y., Oda, M., Nakata, H., Shozaki, Y., Kozasa, T., Todokoro, K. Blood (2001) [Pubmed]
  5. Follicular dendritic cell regulation of CXCR4-mediated germinal center CD4 T cell migration. Estes, J.D., Thacker, T.C., Hampton, D.L., Kell, S.A., Keele, B.F., Palenske, E.A., Druey, K.M., Burton, G.F. J. Immunol. (2004) [Pubmed]
  6. RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes. Yowe, D., Weich, N., Prabhudas, M., Poisson, L., Errada, P., Kapeller, R., Yu, K., Faron, L., Shen, M., Cleary, J., Wilkie, T.M., Gutierrez-Ramos, C., Hodge, M.R. Biochem. J. (2001) [Pubmed]
  7. Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels. Aldenhoven, J., Chen, Y., Moran, C. Cytogenet. Genome Res. (2006) [Pubmed]
  8. Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. Park, I.K., Klug, C.A., Li, K., Jerabek, L., Li, L., Nanamori, M., Neubig, R.R., Hood, L., Weissman, I.L., Clarke, M.F. J. Biol. Chem. (2001) [Pubmed]
  9. Cloning and characterization of a novel regulator of G protein signalling in human platelets. Gagnon, A.W., Murray, D.L., Leadley, R.J. Cell. Signal. (2002) [Pubmed]
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