Gene Review:
ATF3 - activating transcription factor 3
Homo sapiens
Synonyms:
Activating transcription factor 3, Cyclic AMP-dependent transcription factor ATF-3, cAMP-dependent transcription factor ATF-3
- Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway. Yamaguchi, K., Lee, S.H., Kim, J.S., Wimalasena, J., Kitajima, S., Baek, S.J. Cancer Res. (2006)
- ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter. Yan, C., Wang, H., Boyd, D.D. J. Biol. Chem. (2002)
- Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization. Pan, Y.X., Chen, H., Kilberg, M.S. J. Biol. Chem. (2005)
- Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription. Kawauchi, J., Zhang, C., Nobori, K., Hashimoto, Y., Adachi, M.T., Noda, A., Sunamori, M., Kitajima, S. J. Biol. Chem. (2002)
- Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon. Pimkhaokham, A., Shimada, Y., Fukuda, Y., Kurihara, N., Imoto, I., Yang, Z.Q., Imamura, M., Nakamura, Y., Amagasa, T., Inazawa, J. Jpn. J. Cancer Res. (2000)
- A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Kang, Y., Chen, C.R., Massagué, J. Mol. Cell (2003)
- Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. Yan, C., Lu, D., Hai, T., Boyd, D.D. EMBO J. (2005)
- Oxidative stress-responsive transcription factor ATF3 potentially mediates diabetic angiopathy. Okamoto, A., Iwamoto, Y., Maru, Y. Mol. Cell. Biol. (2006)
- Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene. Bottone, F.G., Moon, Y., Alston-Mills, B., Eling, T.E. J. Pharmacol. Exp. Ther. (2005)
- Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. Ameri, K., Hammond, E.M., Culmsee, C., Raida, M., Katschinski, D.M., Wenger, R.H., Wagner, E., Davis, R.J., Hai, T., Denko, N., Harris, A.L. Oncogene (2007)
- Activating transcription factor 3 is up-regulated in patients with hypospadias. Liu, B., Wang, Z., Lin, G., Agras, K., Ebbers, M., Willingham, E., Baskin, L.S. Pediatr. Res. (2005)
- The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3). Bottone, F.G., Moon, Y., Kim, J.S., Alston-Mills, B., Ishibashi, M., Eling, T.E. Mol. Cancer Ther. (2005)
- The expression of transcription factor activating transcription factor 3 in the human prostate and its regulation by androgen in prostate cancer. Pelzer, A.E., Bektic, J., Haag, P., Berger, A.P., Pycha, A., Schäfer, G., Rogatsch, H., Horninger, W., Bartsch, G., Klocker, H. J. Urol. (2006)
- ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: a novel cardioprotective role of ATF3. Nobori, K., Ito, H., Tamamori-Adachi, M., Adachi, S., Ono, Y., Kawauchi, J., Kitajima, S., Marumo, F., Isobe, M. J. Mol. Cell. Cardiol. (2002)
- Sensory neurons and their supporting cells located in the trigeminal, thoracic and lumbar ganglia differentially express markers of injury following intravenous administration of paclitaxel in the rat. Jimenez-Andrade, J.M., Peters, C.M., Mejia, N.A., Ghilardi, J.R., Kuskowski, M.A., Mantyh, P.W. Neurosci. Lett. (2006)
- ATF3 enhances c-Jun-mediated neurite sprouting. Pearson, A.G., Gray, C.W., Pearson, J.F., Greenwood, J.M., During, M.J., Dragunow, M. Brain Res. Mol. Brain Res. (2003)
- ATF3 gene. Genomic organization, promoter, and regulation. Liang, G., Wolfgang, C.D., Chen, B.P., Chen, T.H., Hai, T. J. Biol. Chem. (1996)
- Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. Pan, Y., Chen, H., Siu, F., Kilberg, M.S. J. Biol. Chem. (2003)
- ATF3 regulates the stability of p53: a link to cancer. Yan, C., Boyd, D.D. Cell Cycle (2006)
- ATF and Jun transcription factors, acting through an Ets/CRE promoter module, mediate lipopolysaccharide inducibility of the chemokine RANTES in monocytic Mono Mac 6 cells. Boehlk, S., Fessele, S., Mojaat, A., Miyamoto, N.G., Werner, T., Nelson, E.L., Schlöndorff, D., Nelson, P.J. Eur. J. Immunol. (2000)
- Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner. Lee, S.H., Kim, J.S., Yamaguchi, K., Eling, T.E., Baek, S.J. Biochem. Biophys. Res. Commun. (2005)
- Interleukin-10 induced activating transcription factor 3 transcriptional suppression of matrix metalloproteinase-2 gene expression in human prostate CPTX-1532 Cells. Stearns, M.E., Kim, G., Garcia, F., Wang, M. Mol. Cancer Res. (2004)
- Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels. Aldenhoven, J., Chen, Y., Moran, C. Cytogenet. Genome Res. (2006)
- Novel interactions between human T-cell leukemia virus type I Tax and activating transcription factor 3 at a cyclic AMP-responsive element. Low, K.G., Chu, H.M., Schwartz, P.M., Daniels, G.M., Melner, M.H., Comb, M.J. Mol. Cell. Biol. (1994)
- Wounding activates p38 map kinase and activation transcription factor 3 in leading keratinocytes. Harper, E.G., Alvares, S.M., Carter, W.G. J. Cell. Sci. (2005)
- Expression of transcriptional repressor ATF3/LRF1 in human atherosclerosis: colocalization and possible involvement in cell death of vascular endothelial cells. Nawa, T., Nawa, M.T., Adachi, M.T., Uchimura, I., Shimokawa, R., Fujisawa, K., Tanaka, A., Numano, F., Kitajima, S. Atherosclerosis (2002)