Gene Review:
FKBP5 - FK506 binding protein 5
Homo sapiens
Synonyms:
51 kDa FK506-binding protein, 51 kDa FKBP, 54 kDa progesterone receptor-associated immunophilin, AIG6, Androgen-regulated protein 6, ...
Giraudier,
Chagraoui,
Komura,
Barnache,
Blanchet,
LeCouedic,
Smith,
Larbret,
Taksin,
Moreau-Gachelin,
Casadevall,
Tulliez,
Hulin,
Debili,
Vainchenker,
Gawlik,
Moller-Ehrlich,
Mende,
Jovnerovski,
Jung,
Jabs,
Knapp,
Stoeber,
Binder,
Salyakina,
Lichtner,
Wochnik,
Ising,
Pütz,
Papiol,
Seaman,
Lucae,
Kohli,
Nickel,
Künzel,
Fuchs,
Majer,
Pfennig,
Kern,
Brunner,
Modell,
Baghai,
Deiml,
Zill,
Bondy,
Rupprecht,
Messer,
Köhnlein,
Dabitz,
Brückl,
Müller,
Pfister,
Lieb,
Mueller,
Lõhmussaar,
Strom,
Bettecken,
Meitinger,
Uhr,
Rein,
Holsboer,
Muller-Myhsok,
Bock,
Neusch,
Büsche,
Mengel,
Kreipe,
- Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer. Febbo, P.G., Lowenberg, M., Thorner, A.R., Brown, M., Loda, M., Golub, T.R. J. Urol. (2005)
- Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors. Giraudier, S., Chagraoui, H., Komura, E., Barnache, S., Blanchet, B., LeCouedic, J.P., Smith, D.F., Larbret, F., Taksin, A.L., Moreau-Gachelin, F., Casadevall, N., Tulliez, M., Hulin, A., Debili, N., Vainchenker, W. Blood (2002)
- Coexpression of folding accessory proteins for production of active cyclodextrin glycosyltransferase of Bacillus macerans in recombinant Escherichia coli. Kim, S.G., Kweon, D.H., Lee, D.H., Park, Y.C., Seo, J.H. Protein Expr. Purif. (2005)
- Immunophilins and their ligands: insights into survival and growth of human neurons. Avramut, M., Achim, C.L. Physiol. Behav. (2002)
- Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages. Leuzzi, R., Serino, L., Scarselli, M., Savino, S., Fontana, M.R., Monaci, E., Taddei, A., Fischer, G., Rappuoli, R., Pizza, M. Mol. Microbiol. (2005)
- Shortfalls in the peptidyl-prolyl cis-trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias. Thorpe, J.R., Mosaheb, S., Hashemzadeh-Bonehi, L., Cairns, N.J., Kay, J.E., Morley, S.J., Rulten, S.L. Neurobiol. Dis. (2004)
- Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Binder, E.B., Salyakina, D., Lichtner, P., Wochnik, G.M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M.A., Nickel, T., Künzel, H.E., Fuchs, B., Majer, M., Pfennig, A., Kern, N., Brunner, J., Modell, S., Baghai, T., Deiml, T., Zill, P., Bondy, B., Rupprecht, R., Messer, T., Köhnlein, O., Dabitz, H., Brückl, T., Müller, N., Pfister, H., Lieb, R., Mueller, J.C., Lõhmussaar, E., Strom, T.M., Bettecken, T., Meitinger, T., Uhr, M., Rein, T., Holsboer, F., Muller-Myhsok, B. Nat. Genet. (2004)
- The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo. Riggs, D.L., Roberts, P.J., Chirillo, S.C., Cheung-Flynn, J., Prapapanich, V., Ratajczak, T., Gaber, R., Picard, D., Smith, D.F. EMBO J. (2003)
- A novel multi-functional chloroplast protein: identification of a 40 kDa immunophilin-like protein located in the thylakoid lumen. Fulgosi, H., Vener, A.V., Altschmied, L., Herrmann, R.G., Andersson, B. EMBO J. (1998)
- Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Sinars, C.R., Cheung-Flynn, J., Rimerman, R.A., Scammell, J.G., Smith, D.F., Clardy, J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. Magee, J.A., Chang, L.W., Stormo, G.D., Milbrandt, J. Endocrinology (2006)
- Identification of novel direct transcriptional targets of glucocorticoid receptor. U, M., Shen, L., Oshida, T., Miyauchi, J., Yamada, M., Miyashita, T. Leukemia (2004)
- Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids. Hubler, T.R., Scammell, J.G. Cell Stress Chaperones (2004)
- Calcium- and FK506-independent interaction between the immunophilin FKBP51 and calcineurin. Li, T.K., Baksh, S., Cristillo, A.D., Bierer, B.E. J. Cell. Biochem. (2002)
- Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. Silverstein, A.M., Galigniana, M.D., Chen, M.S., Owens-Grillo, J.K., Chinkers, M., Pratt, W.B. J. Biol. Chem. (1997)
- Effect of geldanamycin on androgen receptor function and stability. Vanaja, D.K., Mitchell, S.H., Toft, D.O., Young, C.Y. Cell Stress Chaperones (2002)
- The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness. Hubler, T.R., Denny, W.B., Valentine, D.L., Cheung-Flynn, J., Smith, D.F., Scammell, J.G. Endocrinology (2003)
- Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51. Reynolds, P.D., Ruan, Y., Smith, D.F., Scammell, J.G. J. Clin. Endocrinol. Metab. (1999)
- Structure-function analysis of squirrel monkey FK506-binding protein 51, a potent inhibitor of glucocorticoid receptor activity. Denny, W.B., Prapapanich, V., Smith, D.F., Scammell, J.G. Endocrinology (2005)
- FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. Wochnik, G.M., Rüegg, J., Abel, G.A., Schmidt, U., Holsboer, F., Rein, T. J. Biol. Chem. (2005)
- FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts. Smith, D.F., Albers, M.W., Schreiber, S.L., Leach, K.L., Deibel, M.R. J. Biol. Chem. (1993)
- Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. Pirkl, F., Buchner, J. J. Mol. Biol. (2001)
- Molecular genetics of bipolar disorder and depression. Kato, T. Psychiatry Clin. Neurosci. (2007)
- Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits. Gawlik, M., Moller-Ehrlich, K., Mende, M., Jovnerovski, M., Jung, S., Jabs, B., Knapp, M., Stoeber, G. BMC psychiatry (2006)
- Constitutive expression of the FK506 binding protein 51 (FKBP51) in bone marrow cells and megakaryocytes derived from idiopathic myelofibrosis and non-neoplastic haematopoiesis. Bock, O., Neusch, M., Büsche, G., Mengel, M., Kreipe, H. Eur. J. Haematol. (2004)
- Identification and validation of novel androgen-regulated genes in prostate cancer. Velasco, A.M., Gillis, K.A., Li, Y., Brown, E.L., Sadler, T.M., Achilleos, M., Greenberger, L.M., Frost, P., Bai, W., Zhang, Y. Endocrinology (2004)