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Gene Review

Hbp1  -  high mobility group box transcription...

Mus musculus

Synonyms: 1700058O05Rik, BE629963, C330012F01Rik, C86454, HMG box transcription factor 1, ...
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High impact information on Hbp1


Biological context of Hbp1


Anatomical context of Hbp1

  • We have found mouse Hbp1 to be expressed strongly in the embryonic mouse testis from approximately 12.5 days post coitum, compared with low levels of expression in the embryonic ovary [6].
  • The expression of Hbp1 in XY germ cells appears to correlate with the onset of mitotic arrest in these cells [6].
  • We conclude that Hbp1 is up-regulated specifically in germ cells of the developing XY gonad [6].
  • Whole-mount in situ hybridisation analysis showed that expression of Hbp1 in the XY gonad is localized within the developing testis cords, the precursors of the seminiferous tubules [6].
  • We show that SOX2, an HMG box transcription factor, is expressed in multipotent neural stem cells at all stages of mouse ontogeny [7].

Other interactions of Hbp1

  • In situ hybridisation analysis on cryosectioned embryonic testis indicated that Hbp1 expression resembles that of the germ cell marker Oct4 [6].
  • In data that we present here, we show that Alx-4 is expressed in mesenchymal condensations of a diverse group of tissues whose development is dependent on epithelial-mesenchymal interactions, many of which are additionally dependent on expression of the HMG-box-containing protein, LEF-1 [8].
  • Sequence and expression of Sox-18 encoding a new HMG-box transcription factor [9].
  • SOX1, an HMG box transcription factor, is expressed widely in neural precursors along with the two other SOXB1 subfamily members, SOX2 and SOX3, and all three have been implicated in neurogenesis [10].


  1. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Zhou, Q., Wang, S., Anderson, D.J. Neuron (2000) [Pubmed]
  2. Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR. Boyd, K.E., Xiao, Y.Y., Fan, K., Poholek, A., Copeland, N.G., Jenkins, N.A., Perkins, A.S. Blood (2006) [Pubmed]
  3. Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Sawada, S., Littman, D.R. Mol. Cell. Biol. (1991) [Pubmed]
  4. Sox9 is required for notochord maintenance in mice. Barrionuevo, F., Taketo, M.M., Scherer, G., Kispert, A. Dev. Biol. (2006) [Pubmed]
  5. The HMG box transcription factor gene Sox14 marks a novel subset of ventral interneurons and is regulated by sonic hedgehog. Hargrave, M., Karunaratne, A., Cox, L., Wood, S., Koopman, P., Yamada, T. Dev. Biol. (2000) [Pubmed]
  6. HMG box transcription factor gene Hbp1 is expressed in germ cells of the developing mouse testis. Smith, J.M., Bowles, J., Wilson, M., Koopman, P. Dev. Dyn. (2004) [Pubmed]
  7. SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. Ellis, P., Fagan, B.M., Magness, S.T., Hutton, S., Taranova, O., Hayashi, S., McMahon, A., Rao, M., Pevny, L. Dev. Neurosci. (2004) [Pubmed]
  8. Alx-4, a transcriptional activator whose expression is restricted to sites of epithelial-mesenchymal interactions. Hudson, R., Taniguchi-Sidle, A., Boras, K., Wiggan, O., Hamel, P.A. Dev. Dyn. (1998) [Pubmed]
  9. Sequence and expression of Sox-18 encoding a new HMG-box transcription factor. Dunn, T.L., Mynett-Johnson, L., Wright, E.M., Hosking, B.M., Koopman, P.A., Muscat, G.E. Gene (1995) [Pubmed]
  10. Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. Ekonomou, A., Kazanis, I., Malas, S., Wood, H., Alifragis, P., Denaxa, M., Karagogeos, D., Constanti, A., Lovell-Badge, R., Episkopou, V. PLoS Biol. (2005) [Pubmed]
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