The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Sox18  -  SRY (sex determining region Y)-box 18

Mus musculus

Synonyms: AI385749, Ra, Ragl, Sox-18, Sry-related HMG-box gene 18, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Sox18

  • Mutations in human and mouse Sox18 leads to hypotrichosis and lymphedema [1].
  • Lipopolysaccharide (LPS) extracted from three strains of Salmonella typhimurium, i.e., the rough Re mutant SL1102, the rough Ra mutant TV119, and the smooth strain SH4809, was first electrodialyzed (eLPS) and then divalent cation deprived by EDTA treatment and finally made monomeric by deoxycholate solubilization [2].
  • In contrast, a high inoculum of either a Ra mutant (strain TV148) of strain LT2 or S. schottmülleri 8006 sharing the same O antigenic components with those of S. typhimurium induced only a short-lived protection in proportion to the number of L forms in the liver, and the protective immunity was lost before day 180 [3].
 

High impact information on Sox18

 

Biological context of Sox18

 

Anatomical context of Sox18

 

Associations of Sox18 with chemical compounds

  • The rate of appearance (Ra) of glycerol, which indicates lipolytic rates, was similar at baseline and after 4 wk of CLA supplementation at rest (1.87 +/- 0.21 and 2.00 +/- 0.39 micromol/kg/min, respectively) and during exercise (7.12 +/- 0.74 and 6.40 +/- 0.99 micromol/kg/min, respectively) [9].
  • 3H-3-glucose was infused for measurement of the glucose turnover rate (rate of appearance [Ra]) [10].
 

Physical interactions of Sox18

 

Regulatory relationships of Sox18

 

Other interactions of Sox18

  • Here, we provide direct evidence for redundant function of Sox17 and Sox18 in postnatal neovascularization by generating Sox17(+/-)-Sox18(-/-) double mutant mice [11].
  • Importantly, the naturally occurring Sox18 mutant attenuates the expression and activation of VCAM-1 in vitro [1].
  • From the current data Ada can be taken as the proximal, and Ra as the distal gene marker of the imprinting region on the linkage map [12].
  • The Sry-related HMG box transcription factor, Sox17, is required for formation of definitive endoderm that gives rise to various organs, including thyroid, lung, liver, pancreas, and intestine [13].
  • Sequence and expression of Sox-18 encoding a new HMG-box transcription factor [14].
 

Analytical, diagnostic and therapeutic context of Sox18

  • We use biochemical techniques, cell culture systems, and the ragged opossum (RaOP) mouse model with a naturally occurring mutation in Sox18 to demonstrate that VCAM-1 is an important target of Sox18 [1].
  • Here we describe the analysis of Sox18(-/-) mice produced by gene targeting [15].
  • Adoptive transfer of IHLs from immune-competent mice immunized with Ad-lacZ into Ragl-deficient mice previously infused with Ad-lacZ resulted in rapid elimination of beta-galactosidase-transduced hepatocytes [16].
  • LPS did not affect I-Lep transport when studied by the brain perfusion method nor was Ob-Ra mRNA expression in isolated brain microvessels altered, demonstrating that a circulating factor rather than altered BBB function was responsible for inhibition [17].

References

  1. The VCAM-1 gene that encodes the vascular cell adhesion molecule is a target of the Sry-related high mobility group box gene, Sox18. Hosking, B.M., Wang, S.C., Downes, M., Koopman, P., Muscat, G.E. J. Biol. Chem. (2004) [Pubmed]
  2. Role of the physical state of Salmonella lipopolysaccharide in expression of biological and endotoxic properties. Shnyra, A., Hultenby, K., Lindberg, A.A. Infect. Immun. (1993) [Pubmed]
  3. Mechanism of the protective immunity against murine typhoid: persistence of Salmonella L forms in the liver after immunization with live-cell vaccines. Kita, E., Nishikawa, F., Kamikaidou, N., Oku, D., Yasui, K., Kashiba, S. FEMS microbiology immunology. (1992) [Pubmed]
  4. Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice. Pennisi, D., Gardner, J., Chambers, D., Hosking, B., Peters, J., Muscat, G., Abbott, C., Koopman, P. Nat. Genet. (2000) [Pubmed]
  5. Sox18 is transiently expressed during angiogenesis in granulation tissue of skin wounds with an identical expression pattern to Flk-1 mRNA. Darby, I.A., Bisucci, T., Raghoenath, S., Olsson, J., Muscat, G.E., Koopman, P. Lab. Invest. (2001) [Pubmed]
  6. Transcriptional modulation of mouse mu-opioid receptor distal promoter activity by Sox18. Im, H.J., Smirnov, D., Yuhi, T., Raghavan, S., Olsson, J.E., Muscat, G.E., Koopman, P., Loh, H.H. Mol. Pharmacol. (2001) [Pubmed]
  7. Depletion of definitive gut endoderm in Sox17-null mutant mice. Kanai-Azuma, M., Kanai, Y., Gad, J.M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P.P., Hayashi, Y. Development (2002) [Pubmed]
  8. Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Smits, P., Lefebvre, V. Development (2003) [Pubmed]
  9. Conjugated linoleic acid supplementation in humans: effects on fatty acid and glycerol kinetics. Zambell, K.L., Horn, W.F., Keim, N.L. Lipids (2001) [Pubmed]
  10. Dose-response relationship of insulin to glucose fluxes in the awake and unrestrained mouse. Shen, H.Q., Zhu, J.S., Baron, A.D. Metab. Clin. Exp. (1999) [Pubmed]
  11. Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. Matsui, T., Kanai-Azuma, M., Hara, K., Matoba, S., Hiramatsu, R., Kawakami, H., Kurohmaru, M., Koopman, P., Kanai, Y. J. Cell. Sci. (2006) [Pubmed]
  12. Mapping studies of the distal imprinting region of mouse chromosome 2. Peters, J., Beechey, C.V., Ball, S.T., Evans, E.P. Genet. Res. (1994) [Pubmed]
  13. Sox17 influences the differentiation of respiratory epithelial cells. Park, K.S., Wells, J.M., Zorn, A.M., Wert, S.E., Whitsett, J.A. Dev. Biol. (2006) [Pubmed]
  14. Sequence and expression of Sox-18 encoding a new HMG-box transcription factor. Dunn, T.L., Mynett-Johnson, L., Wright, E.M., Hosking, B.M., Koopman, P.A., Muscat, G.E. Gene (1995) [Pubmed]
  15. Mice null for sox18 are viable and display a mild coat defect. Pennisi, D., Bowles, J., Nagy, A., Muscat, G., Koopman, P. Mol. Cell. Biol. (2000) [Pubmed]
  16. Fas-Fas ligand interactions play a major role in effector functions of cytotoxic T lymphocytes after adenovirus vector-mediated gene transfer. Chirmule, N., Moscioni, A.D., Qian, Y., Qian, R., Chen, Y., Wilson, J.M. Hum. Gene Ther. (1999) [Pubmed]
  17. Effects of lipopolysaccharide on leptin transport across the blood-brain barrier. Nonaka, N., Hileman, S.M., Shioda, S., Vo, T.Q., Banks, W.A. Brain Res. (2004) [Pubmed]
 
WikiGenes - Universities