The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CAMKV  -  CaM kinase-like vesicle-associated

Homo sapiens

Synonyms: 1G5, CaM kinase-like vesicle-associated protein, MGC8407, VACAMKL
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CAMKV

  • In 1G5, a Jurkat-derived T cell line stably transfected with a luciferase gene driven by HIV-1 long terminal repeat (LTR), we found that PGE2 markedly enhanced HIV-1 LTR-mediated reporter gene activity [1].
  • The characteristics of 1G5 make it a valuable reagent for studies of HIV infection, HIV regulatory agents, and other T cell or HIV-activating factors, and for screening potential anti-HIV therapeutic agents [2].

High impact information on CAMKV

  • We have characterized cDNA clones of 1G5, an mRNA highly enriched in the mammalian forebrain that encodes a 504-residue protein found in association with perikaryal membranes and neurites [3].
  • The sequence of the 1G5 protein highly resembles those of protein kinases with serine/threonine specificity; however, although most residues universally conserved among protein kinases are present, a few signature residues are absent from the 1G5 protein [3].
  • Using a CD4-positive human lymphoid T cell line (1G5) containing a stably integrated HIV-1 long terminal repeat (LTR)-luciferase construct, we found that LPG is a potent inducer of HIV-1 LTR activity [4].
  • SLS also decreased, in a dose-dependent manner, the HIV-1-dependent syncytium formation between 1G5 and J1.1 cells after a 24-h incubation [5].
  • 1G5 is a clonal cell line derived from Jurkat T cells stably transfected with a luciferase gene driven by an HIV-1 long terminal repeat (HIV-LTR) [2].

Biological context of CAMKV


Anatomical context of CAMKV

  • To further analyze this NKI-L16-dependent increment of syncytium formation in a quantitative assay, a new luciferase-based assay was developed by using a T-cell line containing an HIV-1 long terminal repeat (LTR)-driven luciferase construct (1G5) in coincubation with an HIV-1-positive cell line (J1.1) [7].
  • By using the enzyme-linked immunosorbent assay method, two clones, 4G6 and 1G5, were found to cross-react with human fibroblast 75kDa gelatinase, although none of the four antibodies inhibited gelatinase activity [8].
  • Four monoclonal antibodies to human polymorphonuclear leukocyte gelatinase, 100 kDa type IV collagenase, 1G5, 4C6, 4G6 and 4H4 clones, were generated by immunizing Balb/c mice and fusing the mouse spleen cells with P3U1 cells [8].

Analytical, diagnostic and therapeutic context of CAMKV

  • Immunohistochemical studies were performed using 3 monoclonal anti-MUC 1 antibodies (12C10, 1G5, and H23) on surgical specimens and on fine-needle aspiration biopsy specimens [9].


  1. Prostaglandin E2 Up-regulates HIV-1 long terminal repeat-driven gene activity in T cells via NF-kappaB-dependent and -independent signaling pathways. Dumais, N., Barbeau, B., Olivier, M., Tremblay, M.J. J. Biol. Chem. (1998) [Pubmed]
  2. A sensitive reporter cell line for HIV-1 tat activity, HIV-1 inhibitors, and T cell activation effects. Aguilar-Cordova, E., Chinen, J., Donehower, L., Lewis, D.E., Belmont, J.W. AIDS Res. Hum. Retroviruses (1994) [Pubmed]
  3. 1G5: a calmodulin-binding, vesicle-associated, protein kinase-like protein enriched in forebrain neurites. Godbout, M., Erlander, M.G., Hasel, K.W., Danielson, P.E., Wong, K.K., Battenberg, E.L., Foye, P.E., Bloom, F.E., Sutcliffe, J.G. J. Neurosci. (1994) [Pubmed]
  4. The lipophosphoglycan of Leishmania donovani up-regulates HIV-1 transcription in T cells through the nuclear factor-kappaB elements. Bernier, R., Barbeau, B., Tremblay, M.J., Olivier, M. J. Immunol. (1998) [Pubmed]
  5. Sodium lauryl sulfate abrogates human immunodeficiency virus infectivity by affecting viral attachment. Bestman-Smith, J., Piret, J., Désormeaux, A., Tremblay, M.J., Omar, R.F., Bergeron, M.G. Antimicrob. Agents Chemother. (2001) [Pubmed]
  6. Triggering of apoptosis is not sufficient to induce human immunodeficiency virus gene expression. Oakley, J.D., Taher, M.M., Hershey, C.M., Aggarwal, P.C., Estwani, I.B., Valerie, K. IUBMB Life (2003) [Pubmed]
  7. Modulation of human immunodeficiency virus type 1-induced syncytium formation by the conformational state of LFA-1 determined by a new luciferase-based syncytium quantitative assay. Barbeau, B., Fortin, J.F., Genois, N., Tremblay, M.J. J. Virol. (1998) [Pubmed]
  8. Monoclonal antibodies to human polymorphonuclear leukocyte gelatinase (type IV collagenase) are cross-reactive with fibroblast gelatinase. Kobayashi, T., Hori, H., Kanamori, T., Hattori, S., Takagi, T., Watanabe, H., Nishikawa, T., Nagai, Y. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  9. Differential MUC 1 expression in normal and neoplastic human pancreatic tissue. An immunohistochemical study of 60 samples. Monges, G.M., Mathoulin-Portier, M.P., Acres, R.B., Houvenaeghel, G.F., Giovannini, M.F., Seitz, J.F., Bardou, V.J., Payan, M.J., Olive, D. Am. J. Clin. Pathol. (1999) [Pubmed]
WikiGenes - Universities