The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

JADE1  -  jade family PHD finger 1

Homo sapiens

Synonyms: JADE-1, Jade family PHD finger protein 1, KIAA1807, PHD finger protein 17, PHF17, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PHF17


Psychiatry related information on PHF17

  • The fluorescent agent Fluoro Jade was applied to cortical brain sections obtained from human patients at early postnatal ages and in patients with Alzheimer's disease, and from a Cebus apella monkey after mechanical lesioning of the cerebral cortex [5].

High impact information on PHF17


Chemical compound and disease context of PHF17

  • The lower the O2 saturation recorded at the entrance (2659 m) of Jade Mountain, the higher the score of the Lake Louise Acute Mountain Sickness Score (LLAMSS) [4].

Biological context of PHF17


Anatomical context of PHF17

  • Biochemical cell fractionation studies as well as confocal images of cells immunostained with a specific Jade-1 antibody revealed that endogenous Jade-1 is localized predominantly in the cell nucleus [2].
  • Fluoro Jade labeled reactive astrocytes and early differentiating astroglial cells [5].

Associations of PHF17 with chemical compounds

  • The sorption of artificial dye effluent made from two different dyes, Solar orange 7 GLL and Solar Jade Green FFB from Clariant, onto three different agricultural residues--barley husk, sugarcane bagasse, and wheat straw--was studied [8].

Physical interactions of PHF17


Regulatory relationships of PHF17


Analytical, diagnostic and therapeutic context of PHF17


  1. Jade-1, a candidate renal tumor suppressor that promotes apoptosis. Zhou, M.I., Foy, R.L., Chitalia, V.C., Zhao, J., Panchenko, M.V., Wang, H., Cohen, H.T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity. Panchenko, M.V., Zhou, M.I., Cohen, H.T. J. Biol. Chem. (2004) [Pubmed]
  3. Fluoro-Jade: New fluorescent marker of Rosenthal fibers. Tanaka, K.F., Ochi, N., Hayashi, T., Ikeda, E., Ikenaka, K. Neurosci. Lett. (2006) [Pubmed]
  4. Acute mountain sickness in Jade Mountain climbers of Taiwan. Kao, W.F., Kuo, C.C., Hsu, T.F., Chang, H., Sung, Y.Y., Yen, D.H., Wu, J.K., Lee, C.H. Aviation, space, and environmental medicine. (2002) [Pubmed]
  5. Fluoro Jade stains early and reactive astroglia in the primate cerebral cortex. Colombo, J.A., Puissant, V.I. J. Histochem. Cytochem. (2002) [Pubmed]
  6. Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent. Zhou, M.I., Wang, H., Foy, R.L., Ross, J.J., Cohen, H.T. Cancer Res. (2004) [Pubmed]
  7. Controlled cortical impact in swine: pathophysiology and biomechanics. Manley, G.T., Rosenthal, G., Lam, M., Morabito, D., Yan, D., Derugin, N., Bollen, A., Knudson, M.M., Panter, S.S. J. Neurotrauma (2006) [Pubmed]
  8. Remediation of textile effluent using agricultural residues. Chandran, C.B., Singh, D., Nigam, P. Appl. Biochem. Biotechnol. (2002) [Pubmed]
  9. The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1. Zhou, M.I., Wang, H., Ross, J.J., Kuzmin, I., Xu, C., Cohen, H.T. J. Biol. Chem. (2002) [Pubmed]
  10. Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. Foy, R.L., Song, I.Y., Chitalia, V.C., Cohen, H.T., Saksouk, N., Cayrou, C., Vaziri, C., Côté, J., Panchenko, M.V. J. Biol. Chem. (2008) [Pubmed]
WikiGenes - Universities