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Disease relevance of Cebus


Psychiatry related information on Cebus


High impact information on Cebus


Chemical compound and disease context of Cebus


Biological context of Cebus


Anatomical context of Cebus

  • Polyacrylamide gel electrophoresis of keratinocyte extracts after this rapid partial purification has revealed in each species tested one (chimpanzee, orangutan, gibbon) or two (gorilla, rhesus, owl, cebus) antigenically crossreactive proteins that migrate in the vicinity of human involucrin [19].
  • The ratio of incorporated to nonincorporated lysine in the brain and spinal cord was higher in the Rhesus than the Cebus monkey [20].
  • In fetal Cebus monkey cerebellum obtained at gestational day 50 and 70, NGFR immunoreactivity was observed as a band composed of developing Purkinje cell neurites [21].
  • EMG responses to sudden displacement of the forelimb were studied in Cebus monkeys tranquilized with Atravet, a phenothiazine tranquilizer [22].
  • Sodium arsenate was administered to five male Cebus apella monkeys by the intravenous and oral routes, and blood, urine, and feces were collected [23].

Associations of Cebus with chemical compounds

  • We examined the effect of route of administration by giving equimolar amounts of NaHBED and deferoxamine (DFO) to Cebus apella monkeys as either a subcutaneous (SC) bolus or a 20-minute intravenous (IV) infusion [24].
  • In the iron-loaded Cebus apella monkey, whereas the PO administration of DFO or HBED even at a dose of 300 to 324 micromol/kg was ineffective, the sc injection of HBED in buffer or its monosodium salt, 75 to 324 micromol/kg, produced a net iron excretion that was nearly three times that observed after similar doses of sc DFO [25].
  • Results obtained with cebus monkeys indicate that dietary myristic (14:0) and palmitic (16:0) acids exert disparate effects on cholesterol metabolism, whereas the ability of linoleic acid (18:2) to decrease total plasma cholesterol displays an upper limit or threshold [26].
  • Effects of dopamine agonists on Cebus apella monkeys with previous long-term exposure to fluphenazine [27].
  • Conflicting evidence for a regulatory role of melatonin on adrenal cortisol production, prompted us to investigate this possibility in a New World primate, the capuchin monkey [28].

Gene context of Cebus

  • Comparative gene mapping of man and Cebus capucinus for PGD, ENO1, PGM2, and SOD1 [29].
  • In Cebus apella monkey, as with other mammalian species tested to date, two different forms of haem oxygenase, HO-1 and HO-2, are detected [15].
  • The present study used the NGFR-5 monoclonal antibody raised against human nerve growth factor receptor (NGFR) to determine the extent of NGFR immunoreactivity within the embryonic and young adult Cebus apella cerebellum as well as the human cerebellum [21].
  • Altogether, the data presented support the proposal that the assay developed to measure PRL in Cebus apella is an adequate tool to study the physiology of PRL in this species [30].
  • A PRL response to thyrotropin releasing hormone (TRH) was demonstrated in 2 nursing Cebus apella females, similar to the response found in nursing woman and rhesus [30].

Analytical, diagnostic and therapeutic context of Cebus


  1. GABA agonists in cebus monkeys with neuroleptic-induced persistent dyskinesias. Andersson, U., Häggström, J.E. Psychopharmacology (Berl.) (1988) [Pubmed]
  2. Chronic treatment with the D1 receptor antagonist, SCH 23390, and the D2 receptor antagonist, raclopride, in cebus monkeys withdrawn from previous haloperidol treatment. Extrapyramidal syndromes and dopaminergic supersensitivity. Lublin, H., Gerlach, J., Peacock, L. Psychopharmacology (Berl.) (1993) [Pubmed]
  3. Haloperidol-induced tardive dyskinesia in monkeys. Gunne, L.M., Bárány, S. Psychopharmacology (Berl.) (1976) [Pubmed]
  4. Delayed onset of progressive dystonia following subacute 3-nitropropionic acid treatment in Cebus apella monkeys. Palfi, S., Leventhal, L., Goetz, C.G., Hantraye, T., Roitberg, B.Z., Sramek, J., Emborg, M., Kordower, J.H. Mov. Disord. (2000) [Pubmed]
  5. Efficacy of Niclosamide as a potential topical antipenetrant (TAP) against cercariae of Schistosoma mansoni in monkeys. Bruce, J.I., Miller, R., Lightner, L., Yoganathan, S. Mem. Inst. Oswaldo Cruz (1992) [Pubmed]
  6. Behavioral and morphological comparison of two nonhuman primate models of Huntington's disease. Roitberg, B.Z., Emborg, M.E., Sramek, J.G., Palfi, S., Kordower, J.H. Neurosurgery (2002) [Pubmed]
  7. The untranslated regions of beta-globin mRNA evolve at a functional rate in higher primates. Martin, S.L., Zimmer, E.A., Davidson, W.S., Wilson, A.C., Kan, Y.W. Cell (1981) [Pubmed]
  8. Dyskinesias evoked in monkeys by weekly administration of haloperidol. Weiss, B., Santelli, S. Science (1978) [Pubmed]
  9. Experimental biharzial bladder cancer: tryptophan metabolism in nonhuman primates experimentally infected with Schistosoma haematobium. Brown, R.R., Kuntz, R.E., Arend, R.A., Moore, J.A., Huang, T. J. Natl. Cancer Inst. (1976) [Pubmed]
  10. A monitoring test for the liability of neuroleptic drugs to induce tardive dyskinesia. Gunne, L.M., Bárány, S. Psychopharmacology (Berl.) (1979) [Pubmed]
  11. Neuropeptide changes in a primate model (Cebus apella) for tardive dyskinesia. Johansson, P.E., Terenius, L., Häggström, J.E., Gunne, L. Neuroscience (1990) [Pubmed]
  12. Regional changes in 2-deoxyglucose uptake associated with neuroleptic-induced tardive dyskinesia in the Cebus monkey. Mitchell, I.J., Crossman, A.R., Liminga, U., Andren, P., Gunne, L.M. Mov. Disord. (1992) [Pubmed]
  13. Dopamine receptor agonist- and antagonist-induced behaviors in primates previously treated with dopamine receptor antagonists: the pathogenetic mechanisms of acute oral dyskinesia. Lublin, H. Clinical neuropharmacology. (1995) [Pubmed]
  14. Experimental maternal and neonatal folate status relationships in nonhuman primates. Blocker, D.E., Ausman, L.M., Meadows, C.A., Thenen, S.W. Am. J. Clin. Nutr. (1989) [Pubmed]
  15. Heterogeneity of haem oxygenase 1 and 2 isoenzymes. Rat and primate transcripts for isoenzyme 2 differ in number and size. Trakshel, G.M., Ewing, J.F., Maines, M.D. Biochem. J. (1991) [Pubmed]
  16. The gamma-globin genes and their flanking sequences in primates: findings with nucleotide sequences of capuchin monkey and tarsier. Hayasaka, K., Skinner, C.G., Goodman, M., Slightom, J.L. Genomics (1993) [Pubmed]
  17. Pharmacokinetics of orally administered desferrithiocin analogs in cebus apella primates. Bergeron, R.J., Weimar, W.R., Wiegand, J. Drug Metab. Dispos. (1999) [Pubmed]
  18. Display of proceptive behaviors in relation to urinary and fecal progestin levels over the ovarian cycle in female tufted capuchin monkeys. Carosi, M., Heistermann, M., Visalberghi, E. Hormones and behavior. (1999) [Pubmed]
  19. Primate involucrins: antigenic relatedness and detection of multiple forms. Parenteau, N.L., Eckert, R.L., Rice, R.H. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  20. Incorporation of (3H) lysine into the brain and spinal cord of the cebus (Cebus appella) and rhesus (Macacca mulata) monkeys. Zanakis, M.F., Wells, M.R., Bernstein, J.J. J. Neurosci. Res. (1977) [Pubmed]
  21. Nerve growth factor receptor immunoreactivity in the new world monkey (Cebus apella) and human cerebellum. Mufson, E.J., Higgins, G.A., Kordower, J.H. J. Comp. Neurol. (1991) [Pubmed]
  22. Long-loop reflexes in the tranquilized monkey. Cooke, J.D., Eastman, M.J. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1977) [Pubmed]
  23. Measurement of arsenic bioavailability in soil using a primate model. Roberts, S.M., Weimar, W.R., Vinson, J.R., Munson, J.W., Bergeron, R.J. Toxicol. Sci. (2002) [Pubmed]
  24. HBED ligand: preclinical studies of a potential alternative to deferoxamine for treatment of chronic iron overload and acute iron poisoning. Bergeron, R.J., Wiegand, J., Brittenham, G.M. Blood (2002) [Pubmed]
  25. HBED: the continuing development of a potential alternative to deferoxamine for iron-chelating therapy. Bergeron, R.J., Wiegand, J., Brittenham, G.M. Blood (1999) [Pubmed]
  26. Dietary fatty acid thresholds and cholesterolemia. Hayes, K.C., Khosla, P. FASEB J. (1992) [Pubmed]
  27. Effects of dopamine agonists on Cebus apella monkeys with previous long-term exposure to fluphenazine. Lifshitz, K., O'Keeffe, R.T., Linn, G.S., Lee, K.L., Camp-Bruno, J.A., Suckow, R.F. Biol. Psychiatry (1997) [Pubmed]
  28. mt1 Melatonin receptor in the primate adrenal gland: inhibition of adrenocorticotropin-stimulated cortisol production by melatonin. Torres-Farfan, C., Richter, H.G., Rojas-García, P., Vergara, M., Forcelledo, M.L., Valladares, L.E., Torrealba, F., Valenzuela, G.J., Serón-Ferré, M. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  29. Comparative gene mapping of man and Cebus capucinus for PGD, ENO1, PGM2, and SOD1. Creau-Goldberg, N., Cochet, C., Turleau, C., Finaz, C., de Grouchy, J. Cytogenet. Cell Genet. (1980) [Pubmed]
  30. Development of a radioimmunoassay for Cebus apella prolactin. Vásquez, K., Vergara, M., Recabarren, M., Brandeis, A., Serón-Ferré, M. Biol. Res. (1997) [Pubmed]
  31. Coexistence of GAD-65 and GAD-67 with tyrosine hydroxylase and nitric oxide synthase in amacrine and interplexiform cells of the primate, Cebus apella. Andrade da Costa, B.L., Hokoç, J.N. Vis. Neurosci. (2003) [Pubmed]
  32. Renal handling of urate and oxalate: possible implications for urolithiasis. Lang, F., Greger, R., Sporer, H., Oberleithner, H., Deetjen, P. Urol. Res. (1979) [Pubmed]
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