Gene Review:
Polh - polymerase (DNA directed), eta (RAD 30...
Mus musculus
Synonyms:
DNA polymerase eta, RAD30 homolog A, RAD30A, Rad30a, XPV, ...
- UV-B Radiation Induces Epithelial Tumors in Mice Lacking DNA Polymerase {eta} and Mesenchymal Tumors in Mice Deficient for DNA Polymerase {iota}. Ohkumo, T., Kondo, Y., Yokoi, M., Tsukamoto, T., Yamada, A., Sugimoto, T., Kanao, R., Higashi, Y., Kondoh, H., Tatematsu, M., Masutani, C., Hanaoka, F. Mol. Cell. Biol. (2006)
- Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse. Delbos, F., De Smet, A., Faili, A., Aoufouchi, S., Weill, J.C., Reynaud, C.A. J. Exp. Med. (2005)
- Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta. Yamada, A., Masutani, C., Iwai, S., Hanaoka, F. Nucleic Acids Res. (2000)
- DNA polymerase {eta} is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. Delbos, F., Aoufouchi, S., Faili, A., Weill, J.C., Reynaud, C.A. J. Exp. Med. (2007)
- Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification. Martomo, S.A., Yang, W.W., Wersto, R.P., Ohkumo, T., Kondo, Y., Yokoi, M., Masutani, C., Hanaoka, F., Gearhart, P.J. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene. Pavlov, Y.I., Rogozin, I.B., Galkin, A.P., Aksenova, A.Y., Hanaoka, F., Rada, C., Kunkel, T.A. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Error-prone lesion bypass by human DNA polymerase eta. Zhang, Y., Yuan, F., Wu, X., Rechkoblit, O., Taylor, J.S., Geacintov, N.E., Wang, Z. Nucleic Acids Res. (2000)
- Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice. Lin, Q., Clark, A.B., McCulloch, S.D., Yuan, T., Bronson, R.T., Kunkel, T.A., Kucherlapati, R. Cancer Res. (2006)
- Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Hagendoorn, J., Tong, R., Fukumura, D., Lin, Q., Lobo, J., Padera, T.P., Xu, L., Kucherlapati, R., Jain, R.K. Cancer Res. (2006)