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Gene Review

GSH2  -  glutathione synthetase 2

Arabidopsis thaliana

Synonyms: AtGSH2, F21A20.90, F21A20_90, GLUTATHIONE SYNTHETASE, GSHB
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High impact information on GSH2


Biological context of GSH2


Anatomical context of GSH2

  • As expected, the large (but less abundant) transcript encoded a plastidic GSH2 protein, whereas GSH2 synthesized from the shorter transcript was targeted to the cytosol [4].

Associations of GSH2 with chemical compounds

  • Differential targeting of GSH1 and GSH2 is achieved by multiple transcription initiation: implications for the compartmentation of glutathione biosynthesis in the Brassicaceae [4].
  • These data strongly suggest that the GSH2 gene encodes a bifunctional enzyme that is able to catalyse both the synthesis of GSH by adding glycine to the dipeptide (gammaGlu-Cys) and the synthesis of phytochelatins [7].

Other interactions of GSH2

  • In vitro enzyme assays showed that the cad2-1 mutant has 40% of wild-type levels of GCS activity but is unchanged in the activity of the second enzyme in the pathway, GSH synthetase [8].

Analytical, diagnostic and therapeutic context of GSH2


  1. Glutathione metabolic genes coordinately respond to heavy metals and jasmonic acid in Arabidopsis. Xiang, C., Oliver, D.J. Plant Cell (1998) [Pubmed]
  2. Kinetic mechanism of glutathione synthetase from Arabidopsis thaliana. Jez, J.M., Cahoon, R.E. J. Biol. Chem. (2004) [Pubmed]
  3. AtATM3 is involved in heavy metal resistance in Arabidopsis. Kim, D.Y., Bovet, L., Kushnir, S., Noh, E.W., Martinoia, E., Lee, Y. Plant Physiol. (2006) [Pubmed]
  4. Differential targeting of GSH1 and GSH2 is achieved by multiple transcription initiation: implications for the compartmentation of glutathione biosynthesis in the Brassicaceae. Wachter, A., Wolf, S., Steininger, H., Bogs, J., Rausch, T. Plant J. (2005) [Pubmed]
  5. Cloning of Arabidopsis thaliana glutathione synthetase (GSH2) by functional complementation of a yeast gsh2 mutant. Ullmann, P., Gondet, L., Potier, S., Bach, T.J. Eur. J. Biochem. (1996) [Pubmed]
  6. Cloning of the cDNA and genomic clones for glutathione synthetase from Arabidopsis thaliana and complementation of a gsh2 mutant in fission yeast. Wang, C.L., Oliver, D.J. Plant Mol. Biol. (1996) [Pubmed]
  7. Biosynthesis of phytochelatins in the fission yeast. Phytochelatin synthesis: a second role for the glutathione synthetase gene of Schizosaccharomyces pombe. Al-Lahham, A., Rohde, V., Heim, P., Leuchter, R., Veeck, J., Wunderlich, C., Wolf, K., Zimmermann, M. Yeast (1999) [Pubmed]
  8. The glutathione-deficient, cadmium-sensitive mutant, cad2-1, of Arabidopsis thaliana is deficient in gamma-glutamylcysteine synthetase. Cobbett, C.S., May, M.J., Howden, R., Rolls, B. Plant J. (1998) [Pubmed]
  9. Characterisation of an Arabidopsis thaliana cDNA encoding glutathione synthetase. Rawlins, M.R., Leaver, C.J., May, M.J. FEBS Lett. (1995) [Pubmed]
  10. Identification of a putative flexible loop in Arabidopsis glutathione synthetase. Wang, C.L., Oliver, D.J. Biochem. J. (1997) [Pubmed]
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