Disease relevance of Cdh11

• In addition, we found that cadherin-11 is consistently down-regulated in astrocytomas versus normal brain tissues [1].

High impact information on Cdh11

• Immunostaining of testis cryosections on Postnatal Days 7, 21, 31, 43, and those of adults indicated that cadherin-11 localized to peritubular cell junctions [2].
• Whereas N-cadherin, cadherin-11, and L4-positive cadherin were expressed from Postnatal Day 7 through adulthood, cadherin-6 protein was not present at Postnatal Day 7 and first appeared at Day 21 [2].
• Altogether, these results suggest that the down-regulation of cadherin-11 is a frequent molecular event in the neoplastic transformation of astrocytes and that this down-regulation may be initiated and/or amplified by TGF-alpha autocrine/paracrine loops during tumor progression [1].
• On the other hand, under TGF-alpha treatment, cadherin-11 expression is consistently decreased in all astrocytoma cell lines tested but is increased in normal astrocytes [1].
• Identification of cadherin-11 down-regulation as a common response of astrocytoma cells to transforming growth factor-alpha [1].

Biological context of Cdh11

• Cadherin 11 expression marks the mesenchymal phenotype: towards new functions for cadherins [3]?
• This study shows the overall pattern of cad-11 gene expression during rat embryonic development, from the pregastrula to very late embryonic stage [3].
• As development proceeds, while all epithelium are negative, cad-11 is present in all mesenchymal cells involved in various morphogenetic events, such as the mesenchyme condensations during chondrogenesis and in the formation of sclera, cornea, naris, palate and meninges [3].

Anatomical context of Cdh11

• High levels of cad-11 transcripts were also found in the dispersed cells of the hyaloid plexus in the vitreous body and in the invading mesenchyme within the trabeculae of the outflow tract of the heart [3].
• A proximo-distal and antero-posterior gradient of cad-11 expression is seen in the limb buds, genitalia, and tail [3].

References