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Gene Review

Cdh11  -  cadherin 11

Mus musculus

Synonyms: Cad-11, Cad11, Cadherin-11, OB-cadherin, OSF-4, ...
 
 
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Disease relevance of Cdh11

 

High impact information on Cdh11

 

Biological context of Cdh11

 

Anatomical context of Cdh11

  • The cad-11 expression in the somites was eventually restricted to sclerotome cells [8].
  • In the trunk, the paraxial mesoderm initially did not express cad-11 [8].
  • Cad-11 first appeared in mesodermal layers only in the head and tail regions at the mid-to-late primitive streak stages [8].
  • We previously showed that N-cadherin and cadherin-11 (OB-cadherin), which are highly expressed in normal osteoblasts, are anomalously expressed in human osteosarcoma (Kashima et al., Am J Pathol 1999;155:1549-55) [1].
  • Furthermore, developing nuclei and the superficial zone of the cerebellum expressed cad11, and the cortical plate of the developing cerebrum also did so [10].
 

Associations of Cdh11 with chemical compounds

  • Importantly, SU11248 treatment also resulted in increased expression of cadherin-11 protein in human tumor biopsies in three out of seven patients examined and confirms the feasibility of using transcriptional profiling of preclinical models to identify clinically translatable biomarkers [11].
  • Expression of both N-cadherin and cadherin 11 in the synovial lining was demonstrated by immunohistochemical analysis of mouse synovium [12].
 

Regulatory relationships of Cdh11

 

Other interactions of Cdh11

  • We compared the expression pattern of cad11 with that of R-cadherin in the diencephalon and found that each cadherin delineated a unique set of diencephalic subdivisions [10].
  • Cadherin-11 (cad-11) is a novel member of the cadherin family of cell adhesion molecules, having recently been identified by means of the polymerase chain reaction [8].
  • Cad-11 was thus expressed by restricted populations of mesenchymal cells in early embryos, although it was also expressed in parts of the neural tube, such as the optic vesicle and dorsal midline, and in part of the otic vesicle [8].
  • Second, cad11 expression delineated particular neuromeric compartments at the ventricular zone of the neuroepithelium [10].
  • In the N-cadherin/cad11 double-homozygous mutants, this tendency was also observed, although each half of the somite further disintegrated into randomly arranged cell clusters [14].
 

Analytical, diagnostic and therapeutic context of Cdh11

References

  1. Overexpression of cadherins suppresses pulmonary metastasis of osteosarcoma in vivo. Kashima, T., Nakamura, K., Kawaguchi, J., Takanashi, M., Ishida, T., Aburatani, H., Kudo, A., Fukayama, M., Grigoriadis, A.E. Int. J. Cancer (2003) [Pubmed]
  2. Cell-cell interaction mediated by cadherin-11 directly regulates the differentiation of mesenchymal cells into the cells of the osteo-lineage and the chondro-lineage. Kii, I., Amizuka, N., Shimomura, J., Saga, Y., Kudo, A. J. Bone Miner. Res. (2004) [Pubmed]
  3. A novel function for cadherin-11 in the regulation of motor axon elongation and fasciculation. Marthiens, V., Gavard, J., Padilla, F., Monnet, C., Castellani, V., Lambert, M., Mège, R.M. Mol. Cell. Neurosci. (2005) [Pubmed]
  4. Cadherin-11 is highly expressed in rhabdomyosarcomas and during differentiation of myoblasts in vitro. Markus, M.A., Reichmuth, C., Atkinson, M.J., Reich, U., Hoffmann, I., Balling, R., Anderer, U., Höfler, H. J. Pathol. (1999) [Pubmed]
  5. Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes. Valencia, X., Higgins, J.M., Kiener, H.P., Lee, D.M., Podrebarac, T.A., Dascher, C.C., Watts, G.F., Mizoguchi, E., Simmons, B., Patel, D.D., Bhan, A.K., Brenner, M.B. J. Exp. Med. (2004) [Pubmed]
  6. Differential expression and function of cadherin-6 during renal epithelium development. Cho, E.A., Patterson, L.T., Brookhiser, W.T., Mah, S., Kintner, C., Dressler, G.R. Development (1998) [Pubmed]
  7. In fibroblasts Vegf-D expression is induced by cell-cell contact mediated by cadherin-11. Orlandini, M., Oliviero, S. J. Biol. Chem. (2001) [Pubmed]
  8. Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos. Kimura, Y., Matsunami, H., Inoue, T., Shimamura, K., Uchida, N., Ueno, T., Miyazaki, T., Takeichi, M. Dev. Biol. (1995) [Pubmed]
  9. Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. Okazaki, M., Takeshita, S., Kawai, S., Kikuno, R., Tsujimura, A., Kudo, A., Amann, E. J. Biol. Chem. (1994) [Pubmed]
  10. Expression of cadherin-11 delineates boundaries, neuromeres, and nuclei in the developing mouse brain. Kimura, Y., Matsunami, H., Takeichi, M. Dev. Dyn. (1996) [Pubmed]
  11. Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor. Morimoto, A.M., Tan, N., West, K., McArthur, G., Toner, G.C., Manning, W.C., Smolich, B.D., Cherrington, J.M. Oncogene (2004) [Pubmed]
  12. Coexpression of two mesenchymal cadherins, cadherin 11 and N-cadherin, on murine fibroblast-like synoviocytes. Agarwal, S.K., Lee, D.M., Kiener, H.P., Brenner, M.B. Arthritis Rheum. (2008) [Pubmed]
  13. The transition of cadherin expression in osteoblast differentiation from mesenchymal cells: consistent expression of cadherin-11 in osteoblast lineage. Kawaguchi, J., Kii, I., Sugiyama, Y., Takeshita, S., Kudo, A. J. Bone Miner. Res. (2001) [Pubmed]
  14. Adhesive subdivisions intrinsic to the epithelial somites. Horikawa, K., Radice, G., Takeichi, M., Chisaka, O. Dev. Biol. (1999) [Pubmed]
  15. Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11. Kawaguchi, J., Takeshita, S., Kashima, T., Imai, T., Machinami, R., Kudo, A. J. Bone Miner. Res. (1999) [Pubmed]
  16. Regulated expression of cadherin-11 in human epithelial cells: a role for cadherin-11 in trophoblast-endometrium interactions? MacCalman, C.D., Furth, E.E., Omigbodun, A., Bronner, M., Coutifaris, C., Strauss, J.F. Dev. Dyn. (1996) [Pubmed]
  17. Osteogenic differentiation of mouse embryonic stem cells: differential gene expression analysis by cDNA microarray and purification of osteoblasts by cadherin-11 magnetically activated cell sorting. Bourne, S., Polak, J.M., Hughes, S.P., Buttery, L.D. Tissue engineering. (2004) [Pubmed]
 
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