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Gene Review

FAS1  -  tetrafunctional fatty acid synthase...

Saccharomyces cerevisiae S288c

Synonyms: Fatty acid synthase subunit beta, YKL182W
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Disease relevance of FAS1


High impact information on FAS1

  • Balanced levels of subunits alpha and beta are ensured by an autoregulatory effect of FAS1 on FAS2 expression and by posttranslational degradation of excess FAS subunits [2].
  • In Saccharomyces cerevisiae, FAS1, FAS2, and FAS3 are the genes involved in saturated fatty acid biosynthesis [3].
  • Deletion analyses of the regulatory regions of FAS1 and FAS2 revealed common regulatory sequences [3].
  • We identified mutations in ACC1 and FAS1, two genes important for fatty acid biosynthesis in yeast; ACC1 encodes acetyl coenzyme A carboxylase (Acc1), and FAS1 encodes the beta subunit of fatty acid synthase [4].
  • Complementation of mutations and nucleotide sequence of FAS1 gene encoding beta subunit of yeast fatty acid synthase [5].

Biological context of FAS1

  • In contrast, FAS1 expression becomes Ino2p-independent in nmt1-451D cells at temperatures where efficient acylation of cellular N-myristoylproteins is jeopardized [6].
  • In addition, we show by random-breakage mapping that TRP3 is located approximately 45 kb from the left telomere of chromosome XI, whereas FAS1 is approximately 110 kb from the same telomere [7].
  • Surprisingly, the first 66 nt of the FAS2 coding region turned out as necessary and sufficient for FAS1-dependent gene expression [8].
  • FAS2-lacZ fusion constructs deleted for this region showed high reporter gene expression even in the absence of FAS1, arguing for a negatively-acting downstream repression site (DRS) responsible for FAS1-dependent expression of FAS2 [8].
  • When a FAS2 multicopy plasmid is present in the cells, expression of both FAS1 and FAS3 increases [3].

Anatomical context of FAS1

  • The ability to maintain expression of FAS1 in nmt1-451Dino2 Delta cells suggests the existence of another transcription factor, or factors, whose expression/activity is inversely related to overall levels of cellular protein N-myristoy-lation [6].

Associations of FAS1 with chemical compounds

  • These changes are associated with a net increase in expression of some inositol target genes, including FAS1 . FAS1 encodes one of the subunits of the fatty acid synthase complex that catalyzes de novo acylCoA (including myristoylCoA) biosynthesis [6].
  • Expression of the unlinked genes, FAS1 and FAS2, is in part constitutive and in part subject to repression by the phospholipid precursors inositol and choline [2].
  • The fatty acid synthetase (FAS) gene FAS1 of the alkane-utilizing yeast Yarrowia lipolytica was cloned and sequenced [9].

Other interactions of FAS1

  • Compared to the intact alpha 6 beta 6 complex, the individual FAS subunits synthesized in the delta fas1 or delta fas2 strains exhibit a considerably increased sensitivity towards the proteinases present in the yeast cell homogenate [10].
  • We have investigated the influence of a functional INO4 gene previously described as a regulator of inositol biosynthesis on the expression of FAS1 and FAS2 [11].
  • Finally, we mapped the GPM1 gene 13 cM distal to fas1 on chromosome XI [12].

Analytical, diagnostic and therapeutic context of FAS1


  1. Molecular structure of the multifunctional fatty acid synthetase gene of Brevibacterium ammoniagenes: its sequence of catalytic domains is formally consistent with a head-to-tail fusion of the two yeast genes FAS1 and FAS2. Meurer, G., Biermann, G., Schütz, A., Harth, S., Schweizer, E. Mol. Gen. Genet. (1992) [Pubmed]
  2. Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems. Schweizer, E., Hofmann, J. Microbiol. Mol. Biol. Rev. (2004) [Pubmed]
  3. Coordinated regulation and inositol-mediated and fatty acid-mediated repression of fatty acid synthase genes in Saccharomyces cerevisiae. Chirala, S.S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. Inhibition of acetyl coenzyme A carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae. Shirra, M.K., Patton-Vogt, J., Ulrich, A., Liuta-Tehlivets, O., Kohlwein, S.D., Henry, S.A., Arndt, K.M. Mol. Cell. Biol. (2001) [Pubmed]
  5. Complementation of mutations and nucleotide sequence of FAS1 gene encoding beta subunit of yeast fatty acid synthase. Chirala, S.S., Kuziora, M.A., Spector, D.M., Wakil, S.J. J. Biol. Chem. (1987) [Pubmed]
  6. Transcription of INO2 and INO4 is regulated by the state of protein N-myristoylation in Saccharomyces cerevisiae. Cok, S.J., Martin, C.G., Gordon, J.I. Nucleic Acids Res. (1998) [Pubmed]
  7. The use of random-breakage mapping to locate the genes APN1 and YUH1 in the Saccharomyces genome, and to determine gene order near the left end of chromosome XI. Game, J., Bell, M., Ramotar, D., Miller, H. Yeast (1994) [Pubmed]
  8. A downstream regulatory element located within the coding sequence mediates autoregulated expression of the yeast fatty acid synthase gene FAS2 by the FAS1 gene product. Wenz, P., Schwank, S., Hoja, U., Schüller, H.J. Nucleic Acids Res. (2001) [Pubmed]
  9. The pentafunctional FAS1 genes of Saccharomyces cerevisiae and Yarrowia lipolytica are co-linear and considerably longer than previously estimated. Köttig, H., Rottner, G., Beck, K.F., Schweizer, M., Schweizer, E. Mol. Gen. Genet. (1991) [Pubmed]
  10. Differential proteolytic sensitivity of yeast fatty acid synthetase subunits alpha and beta contributing to a balanced ratio of both fatty acid synthetase components. Schüller, H.J., Förtsch, B., Rautenstrauss, B., Wolf, D.H., Schweizer, E. Eur. J. Biochem. (1992) [Pubmed]
  11. Regulatory gene INO4 of yeast phospholipid biosynthesis is positively autoregulated and functions as a transactivator of fatty acid synthase genes FAS1 and FAS2 from Saccharomyces cerevisiae. Schüller, H.J., Schorr, R., Hoffmann, B., Schweizer, E. Nucleic Acids Res. (1992) [Pubmed]
  12. Sequence and localization of the gene encoding yeast phosphoglycerate mutase. Heinisch, J., von Borstel, R.C., Rodicio, R. Curr. Genet. (1991) [Pubmed]
  13. Molecular cloning of the yeast fatty acid synthetase genes, FAS1 and FAS2: illustrating the structure of the FAS1 cluster gene by transcript mapping and transformation studies. Schweizer, M., Lebert, C., Höltke, J., Roberts, L.M., Schweizer, E. Mol. Gen. Genet. (1984) [Pubmed]
  14. Isolation and sequence of the Candida albicans FAS1 gene. Zhao, X.J., Cihlar, R.L. Gene (1994) [Pubmed]
  15. Importance of general regulatory factors Rap1p, Abf1p and Reb1p for the activation of yeast fatty acid synthase genes FAS1 and FAS2. Schüller, H.J., Schütz, A., Knab, S., Hoffmann, B., Schweizer, E. Eur. J. Biochem. (1994) [Pubmed]
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