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PMI40  -  mannose-6-phosphate isomerase PMI40

Saccharomyces cerevisiae S288c

Synonyms: Mannose-6-phosphate isomerase, PMI, Phosphohexomutase, Phosphomannose isomerase, YER003C
 
 
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Disease relevance of PMI40

  • The heterologous expression of the PMI 1 gene at levels up to 45% of total cell protein in E. coli leads to partitioning of the enzyme between the soluble and particulate fractions [1].
  • Surprisingly, in view of the large differences between Pseudomonas aerugenosa and Saccharomyces cerevisiae PMI, the human and C. albicans enzymes are almost identical [2].
 

High impact information on PMI40

 

Chemical compound and disease context of PMI40

  • We therefore purified PMI from E. coli and showed that this enzyme is not sensitive to inactivation by iodoacetate [6].
 

Biological context of PMI40

 

Associations of PMI40 with chemical compounds

  • After PMI40 deletion (pmi(-)) the cells were viable only if fed with extracellular mannose and glucose [7].
  • The iodoacetate is presumably inhibiting PMI by sterically blocking the mannose 6-phosphate binding site [6].
  • However, metals such as zinc and cadmium, which are reversible, competitive inhibitors for PMI, do not protect the enzyme against modification [6].
 

Other interactions of PMI40

  • Sequencing and functional analysis of the Hansenula polymorpha genomic fragment containing the YPT1 and PMI40 genes [10].

References

  1. Cloning and heterologous expression of the Candida albicans gene PMI 1 encoding phosphomannose isomerase. Smith, D.J., Proudfoot, A.E., Detiani, M., Wells, T.N., Payton, M.A. Yeast (1995) [Pubmed]
  2. Purification and characterization of fungal and mammalian phosphomannose isomerases. Proudfoot, A.E., Payton, M.A., Wells, T.N. J. Protein Chem. (1994) [Pubmed]
  3. Glycosylphosphatidylinositol membrane anchors in Saccharomyces cerevisiae: absence of ceramides from complete precursor glycolipids. Sipos, G., Puoti, A., Conzelmann, A. EMBO J. (1994) [Pubmed]
  4. The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution. Cleasby, A., Wonacott, A., Skarzynski, T., Hubbard, R.E., Davies, G.J., Proudfoot, A.E., Bernard, A.R., Payton, M.A., Wells, T.N. Nat. Struct. Biol. (1996) [Pubmed]
  5. PMI40, an intron-containing gene required for early steps in yeast mannosylation. Smith, D.J., Proudfoot, A., Friedli, L., Klig, L.S., Paravicini, G., Payton, M.A. Mol. Cell. Biol. (1992) [Pubmed]
  6. Identification of Cys-150 in the active site of phosphomannose isomerase from Candida albicans. Coulin, F., Magnenat, E., Proudfoot, A.E., Payton, M.A., Scully, P., Wells, T.N. Biochemistry (1993) [Pubmed]
  7. Excess mannose limits the growth of phosphomannose isomerase PMI40 deletion strain of Saccharomyces cerevisiae. Pitkänen, J.P., Törmä, A., Alff, S., Huopaniemi, L., Mattila, P., Renkonen, R. J. Biol. Chem. (2004) [Pubmed]
  8. Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity. Wills, E.A., Roberts, I.S., Del Poeta, M., Rivera, J., Casadevall, A., Cox, G.M., Perfect, J.R. Mol. Microbiol. (2001) [Pubmed]
  9. Phosphomannose isomerase from Saccharomyces cerevisiae contains two inhibitory metal ion binding sites. Wells, T.N., Coulin, F., Payton, M.A., Proudfoot, A.E. Biochemistry (1993) [Pubmed]
  10. Sequencing and functional analysis of the Hansenula polymorpha genomic fragment containing the YPT1 and PMI40 genes. Kim, M.W., Agaphonov, M.O., Kim, J.Y., Rhee, S.K., Kang, H.A. Yeast (2002) [Pubmed]
 
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