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Gene Review

SLC25A14  -  solute carrier family 25 (mitochondrial...

Homo sapiens

Synonyms: BMCP-1, BMCP1, Brain mitochondrial carrier protein 1, Mitochondrial uncoupling protein 5, Solute carrier family 25 member 14, ...
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Disease relevance of SLC25A14

  • The present results indicate that BMCP1 may be involved in pathogenesis of mitochondrial dysfunction in neurons induced by aging or neurodegenerative disorders, and perhaps in energy balance in the brain [1].
  • Exacerbation of cytotoxicity, oxidative stress and modification of MMP with reduced UCP5 expression in the face of MPP(+) toxicity suggest that UCP5 might be physiologically important in the pathology of oxidative stress-induced neurodegeneration [2].
  • The objective of this study is to demonstrate the effectiveness and feasibility in treating empyema after pulmonary resection with a modified Clagett procedure performed at the bedside (BMCP) [3].

High impact information on SLC25A14


Biological context of SLC25A14


Anatomical context of SLC25A14

  • In 48-h fasted or insulin-induced hypoglycemic rats, BMCP1 mRNA expression in the hypothalamus slightly, but significantly, decreased compared with that in their appropriate controls [1].
  • The effects of classical uncouplers, fatty acids, uncoupling proteins (UCP1-UCP5) and thyroid hormones on the efficiency of OxPhos are described [9].

Other interactions of SLC25A14

  • The UCP signature excluding BMCP1 was also found in the second matrix segment: [positively charged residue]-(Pro/ del-Leu/del)-[positively charged residue]-phi-X-Gly/Ser-Thr/n-X-NH/[negatively charged residue]-Ala-phi [10].
  • Phylogenetic analysis indicates that there are at least three clades of UCPs in invertebrates, which are closely related to vertebrate UCP1-3, UCP4, and UCP5, respectively, and shows early evolutionary divergence of UCPs, which pre-dates the divergence of protostomes and deuterostomes [11].

Analytical, diagnostic and therapeutic context of SLC25A14


  1. Molecular cloning of rat brain mitochondrial carrier protein-1 cDNA and its up-regulation during postnatal development. Kondou, S., Hidaka, S., Yoshimatsu, H., Tsuruta, Y., Itateyama, E., Sakata, T. Biochim. Biophys. Acta (2000) [Pubmed]
  2. Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP(+)-induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity. Ho, P.W., Chu, A.C., Kwok, K.H., Kung, M.H., Ramsden, D.B., Ho, S.L. J. Neurosci. Res. (2006) [Pubmed]
  3. Bedside modified Clagett procedure for empyema after pulmonary resection. Keeling, W.B., Garrett, J.R., Vohra, N., Maxey, T.S., Blazick, E., Sommers, K.E. The American surgeon. (2006) [Pubmed]
  4. BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production. Kim-Han, J.S., Reichert, S.A., Quick, K.L., Dugan, L.L. J. Neurochem. (2001) [Pubmed]
  5. Methyl-4-phenylpyridinium ion modulates expression of mitochondrial uncoupling proteins 2, 4, and 5 in catecholaminergic (SK-N-SH) cells. Ho, P.W., Chan, D.Y., Kwok, K.H., Chu, A.C., Ho, J.W., Kung, M.H., Ramsden, D.B., Ho, S.L. J. Neurosci. Res. (2005) [Pubmed]
  6. Uncoupling proteins: targets of endocrine disruptors? Pawade, T., Ho, P.W., Kwok, K.H., Chu, A.C., Ho, S.L., Ramsden, D.B. Mol. Cell. Endocrinol. (2005) [Pubmed]
  7. UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates. Yang, X., Pratley, R.E., Tokraks, S., Tataranni, P.A., Permana, P.A. Mol. Genet. Metab. (2002) [Pubmed]
  8. Perspectives on the biology of uncoupling protein (UCP) homologues. Adams, S.H., Pan, G., Yu, X.X. Biochem. Soc. Trans. (2001) [Pubmed]
  9. Intrinsic and extrinsic uncoupling of oxidative phosphorylation. Kadenbach, B. Biochim. Biophys. Acta (2003) [Pubmed]
  10. Specific sequence of motifs of mitochondrial uncoupling proteins. Jezek, P., Urbánková, E. IUBMB Life (2000) [Pubmed]
  11. Evolution of mitochondrial uncoupling proteins: novel invertebrate UCP homologues suggest early evolutionary divergence of the UCP family. Sokolova, I.M., Sokolov, E.P. FEBS Lett. (2005) [Pubmed]
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