The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Empyema


High impact information on Empyema


Chemical compound and disease context of Empyema


Biological context of Empyema


Anatomical context of Empyema

  • There was a significant correlation between IL-8 levels and the total numbers of neutrophils in empyema fluids (r = 0.80) [6].
  • VEGF levels were also significantly raised compared with transudates (median 36.5 pg/ml) in empyema (4651 pg/ml (95% CI 833 to 10 000), p<0.001) and parainfectious effusions (360 pg/ml (95% CI 46 to 597), p<0.005) [18].
  • Calculi were found in six ureters and neoplasms in five; ureteritis cystica developed in one, infection secondary to vesicoureteral reflux in one, and empyema proximal to an obstructed ectopic ureteral orifice in another [19].
  • An Indium-111-labeled leukocyte scan was also performed in this patient and demonstrated abnormal uptake in the empyema [20].
  • In tuberculosis, empyema and rheumatoid arthritis ADA activity was significantly higher in pleural fluid than in serum, indicating a local synthesis of ADA by cells within the pleural cavity in these diseases [21].

Gene context of Empyema

  • Compared to noncomplicated PPE, complicated PPE/empyema had significantly higher levels of TNF-alpha, IL-1beta, IL-8 and MIP-1beta [22].
  • Among exudates, tuberculous, empyema and complicated parapneumonic effusions demonstrated higher pleural PAI levels than malignant effusions, whereas t-PA was lowest in empyema and complicated parapneumonic pleural effusions [23].
  • The study revealed that TFPI was present in transudates from patients with CHF and exudative pleural effusions from patients with pneumonia, empyema or pleural carcinoma [24].
  • A negative association found between t-PA and both IL-8 and polymorphonuclear elastase in exudative effusions was strongest in empyema and complicated parapneumonic effusions [23].
  • Our results also indicate that the high levels of IL-8 and G-CSF in empyema may indirectly explain the elevated levels of defensins by increasing the number of neutrophils in the pleural space [25].

Analytical, diagnostic and therapeutic context of Empyema


  1. Ventilator-associated pneumonia by Staphylococcus aureus. Comparison of methicillin-resistant and methicillin-sensitive episodes. Rello, J., Torres, A., Ricart, M., Valles, J., Gonzalez, J., Artigas, A., Rodriguez-Roisin, R. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  2. Chemical and immunological features of pleural effusions: comparison between rheumatoid arthritis and other diseases. Pettersson, T., Klockars, M., Hellström, P.E. Thorax (1982) [Pubmed]
  3. Penetration of tobramycin into infected extravascular fluids and its therapeutic effectiveness. Hall, W.H., Gerding, D.N., Schierl, E.A. J. Infect. Dis. (1977) [Pubmed]
  4. Value of adenosine deaminase in the diagnosis of tuberculous pleural effusions in young patients in a region of high prevalence of tuberculosis. Valdés, L., Alvarez, D., San José, E., Juanatey, J.R., Pose, A., Valle, J.M., Salgueiro, M., Suárez, J.R. Thorax (1995) [Pubmed]
  5. Cefoperazone versus cefamandole in the treatment of acute bacterial lower respiratory tract infections. File, T.M., Tan, J.S., Gardner, W.G., Baird, I. J. Antimicrob. Chemother. (1983) [Pubmed]
  6. Recruitment of inflammatory cells to the pleural space. Chemotactic cytokines, IL-8, and monocyte chemotactic peptide-1 in human pleural fluids. Antony, V.B., Godbey, S.W., Kunkel, S.L., Hott, J.W., Hartman, D.L., Burdick, M.D., Strieter, R.M. J. Immunol. (1993) [Pubmed]
  7. Lower respiratory tract infection. Finegold, S.M., Johnson, C.C. Am. J. Med. (1985) [Pubmed]
  8. Interleukin-8 and markers of neutrophil degranulation in pleural effusions. Segura, R.M., Alegre, J., Varela, E., Marti, R., Suriñach, J.M., Jufresa, J., Armadans, L., Pascual, C., Fernández de Sevilla, T. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  9. Pleural diffusion of voriconazole in a patient with Aspergillus fumigatus empyema thoracis. Stern, J.B., Girard, P., Caliandro, R. Antimicrob. Agents Chemother. (2004) [Pubmed]
  10. Eosinophilic "empyema" associated with crack cocaine use. Strong, D.H., Westcott, J.Y., Biller, J.A., Morrison, J.L., Effros, R.M., Maloney, J.P. Thorax (2003) [Pubmed]
  11. Pharmacokinetics and therapeutic efficacy of gentamicin in an experimental pleural empyema rabbit model. Shohet, I., Yellin, A., Meyerovitch, J., Rubinstein, E. Antimicrob. Agents Chemother. (1987) [Pubmed]
  12. Enterococcus cecorum empyema thoracis successfully treated with cefotaxime. Woo, P.C., Tam, D.M., Lau, S.K., Fung, A.M., Yuen, K.Y. J. Clin. Microbiol. (2004) [Pubmed]
  13. Lactic acid levels in pleural fluid from patients with bacterial pleuritis. Riley, T.V. J. Clin. Microbiol. (1985) [Pubmed]
  14. Antibiotic levels in empyemic pleural fluid. Teixeira, L.R., Sasse, S.A., Villarino, M.A., Nguyen, T., Mulligan, M.E., Light, R.W. Chest (2000) [Pubmed]
  15. Bacteraemic Haemophilus influenzae pneumonia. Allen, M.B., Prowse, K. Eur. Respir. J. (1988) [Pubmed]
  16. The histology of experimental pleural injury with tetracycline, empyema, and carrageenan. Strange, C., Tomlinson, J.R., Wilson, C., Harley, R., Miller, K.S., Sahn, S.A. Exp. Mol. Pathol. (1989) [Pubmed]
  17. Immune status with empyema thoracis. Mishra, O.P., Varshney, K., Usha, n.u.l.l., Ali, Z., Nath, G., Pathak, V.K., Das, B.K. Indian journal of pediatrics. (2004) [Pubmed]
  18. Vascular endothelial growth factor (VEGF) in inflammatory and malignant pleural effusions. Thickett, D.R., Armstrong, L., Millar, A.B. Thorax (1999) [Pubmed]
  19. Radiologic evaluation of the ureteral stump. Pollack, H.M., Banner, M.P., Popky, G.L. Radiology. (1982) [Pubmed]
  20. Detection of subdural empyema with radionuclides. McKillop, J.H., Holtzman, D.S., McDougall, I.R. Clinical nuclear medicine. (1980) [Pubmed]
  21. Adenosine deaminase in the diagnosis of pleural effusions. Pettersson, T., Ojala, K., Weber, T.H. Acta medica Scandinavica. (1984) [Pubmed]
  22. Cytokines and fibrinolytic enzymes in tuberculous and parapneumonic effusions. Lin, F.C., Chen, Y.C., Chen, F.J., Chang, S.C. Clin. Immunol. (2005) [Pubmed]
  23. Association between inflammatory mediators and the fibrinolysis system in infectious pleural effusions. Alemán, C., Alegre, J., Monasterio, J., Segura, R.M., Armadans, L., Anglés, A., Varela, E., Ruiz, E., Fernández de Sevilla, T. Clin. Sci. (2003) [Pubmed]
  24. Tissue factor pathway inhibitor expression by human pleural mesothelial and mesothelioma cells. Bajaj, M.S., Pendurthi, U., Koenig, K., Pueblitz, S., Idell, S. Eur. Respir. J. (2000) [Pubmed]
  25. Elevated pleural fluid levels of defensins in patients with empyema. Ashitani, J., Mukae, H., Nakazato, M., Taniguchi, H., Ogawa, K., Kohno, S., Matsukura, S. Chest (1998) [Pubmed]
  26. Pseudoallescheria boydii pneumonia and empyema: a rare complication of heart transplantation cured with voriconazole. Perlroth, M.G., Miller, J. J. Heart Lung Transplant. (2004) [Pubmed]
  27. Chest tube-related empyema due to methicillin-resistant Staphylococcus aureus: could the chest tube be coated with antiseptics? Torres, H.A., Hanna, H.A., Graviss, L., Chaiban, G., Hachem, R., Chemaly, R.F., Girgawy, E., Raad, I.I. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2006) [Pubmed]
  28. Utility of C-reactive protein measurements for empyema diagnosis after pneumonectomy. Icard, P., Fleury, J.P., Regnard, J.F., Libert, J.M., Magdeleinat, P., Gharbi, N., Brachet, A., Levi, J.F., Levasseur, P. Ann. Thorac. Surg. (1994) [Pubmed]
  29. Pseudomonas cepacia empyema necessitatis after lung transplantation in two patients with cystic fibrosis. Noyes, B.E., Michaels, M.G., Kurland, G., Armitage, J.M., Orenstein, D.M. Chest (1994) [Pubmed]
  30. Decortication for childhood empyema. The primary provider's peccadillo. Kennedy, A.S., Agness, M., Bailey, L., White, J.J. Archives of surgery (Chicago, Ill. : 1960) (1991) [Pubmed]
WikiGenes - Universities