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Gene Review

ZBTB22  -  zinc finger and BTB domain containing 22

Homo sapiens

Synonyms: BING1, Protein BING1, ZBTB22A, ZNF297, ZNF297A, ...
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Disease relevance of ZBTB22

  • Primary cardiac diagnoses included TGA with intact ventricular septum (TGA/IVS, n = 79, 63%), TGA with ventricular septal defect (TGA/VSD, n = 37, 30%), and Taussig Bing Anomaly (TBA, n = 9, 7%) [1].
  • Patients with the Bing Neel type of Waldenström's macroglobulinemia often present with global neurological symptoms [2].
  • Three patients had associated lesions including tetralogy of Fallot, Taussig Bing heart, and mitral stenosis [3].
  • Results indicate the Rinne, Weber and Bing Occlusion tests do not accurately predict the type of hearing impairment as frequently as the literature suggests [4].
  • A diarrhoeal outbreak among adults in China was caused by a new rotavirus, termed ADRV-N, that does not react with antisera directed against group A, B or C rotaviruses [Zhonghua Liu Xing Bing Xue Za Zhi (Chin. Epidemiol.) 19 (1998) 336] [5].

High impact information on ZBTB22

  • The Bing packaging cell line was used for amphotropic virus production [6].
  • We also present evidence for the coexistence of several copies of fru in the grasshopper genome [7].
  • In fruit flies, the gene fruitless (fru) governs the establishment of the potential for male sexual behavior [7].
  • Under normal physiological conditions, the plasma concentrations of reduced and oxidized thiols are such that a major fraction of alpha 1-PI in the circulation in vivo is in the form of mixed disulfides [Laurell, C.-B. (1979) in The Chemistry and Physiology of Human Plasma Proteins (Bing, D. H., Ed.) pp 329-341, Pergamon, New York] [8].
  • To assess the physiologic effects of cherry consumption, we measured plasma urate, antioxidant and inflammatory markers in 10 healthy women who consumed Bing sweet cherries [9].

Biological context of ZBTB22

  • The 2.8-kb genomic fragment that complemented the Car- defect of CR17 and overlapped the fru operon (S. Chattopadhyay, A. Mukherjee, and S. Ghosh, J. Bacteriol. 175:3240-3243, 1993) has now been completely sequenced [10].
  • Bone conduction thresholds did not change significantly during the Bing test in any patient [11].

Anatomical context of ZBTB22

  • Therefore, we conclude that global neurological symptoms in the Bing Neel type of Waldenström's macroglobulinemia like generalized seizures can result from an impairment of glial cells electrophysiological functions [2].
  • Very rarely, it is due to a central nervous system localization, the so-called Bing Neel Syndrome [12].
  • We therefore performed the Bing test on nine patients with this syndrome to evaluate whether it is associated with an air-bone gap or middle ear dysfunction [11].
  • Hearing loss in patients with enlarged vestibular aqueduct: air-bone gap and audiological Bing test [11].
  • The Bing test with the tuning fork placed either on the mastoid or the vertex showed a transition point from Bing positive to negative at approximately 9 dB air-bone gap [13].

Associations of ZBTB22 with chemical compounds


Analytical, diagnostic and therapeutic context of ZBTB22


  1. Current expectations for newborns undergoing the arterial switch operation. Dibardino, D.J., Allison, A.E., Vaughn, W.K., McKenzie, E.D., Fraser, C.D. Ann. Surg. (2004) [Pubmed]
  2. Impairment of electrophysiological function of astrocytes by cerebrospinal fluid from a patient with Waldenström's macroglobulinemia. Köller, H., von Giesen, H.J., Siebler, M. J. Neuroimmunol. (1995) [Pubmed]
  3. "Swiss cheese" septal defects: surgical closure using a single patch with intermediate fixings. Macé, L., Dervanian, P., Le Bret, E., Folliguet, T.A., Lambert, V., Losay, J., Neveux, J.Y. Ann. Thorac. Surg. (1999) [Pubmed]
  4. Clinical accuracy of tuning fork tests. Stankiewicz, J.A., Mowry, H.J. Laryngoscope (1979) [Pubmed]
  5. Cloning and sequence analysis of dsRNA segments 5, 6 and 7 of a novel non-group A, B, C adult rotavirus that caused an outbreak of gastroenteritis in China. Yang, H., Makeyev, E.V., Kang, Z., Ji, S., Bamford, D.H., van Dijk, A.A. Virus Res. (2004) [Pubmed]
  6. Retrovirus-mediated gene transfer of 6-pyruvoyl-tetrahydropterin synthase corrects tetrahydrobiopterin deficiency in fibroblasts from hyperphenylalaninemic patients. Thöny, B., Leimbacher, W., Stuhlmann, H., Heizmann, C.W., Blau, N. Hum. Gene Ther. (1996) [Pubmed]
  7. Alternative Starts of Transcription, Several Paralogues, and Almost-Fixed Interspecific Differences of the Gene fruitless in a Hemimetabolous Insect. Ustinova, J., Mayer, F. J. Mol. Evol. (2006) [Pubmed]
  8. Role of disulfide exchange in alpha 1-protease inhibitor. Tyagi, S.C., Simon, S.R. Biochemistry (1992) [Pubmed]
  9. Consumption of cherries lowers plasma urate in healthy women. Jacob, R.A., Spinozzi, G.M., Simon, V.A., Kelley, D.S., Prior, R.L., Hess-Pierce, B., Kader, A.A. J. Nutr. (2003) [Pubmed]
  10. Molecular cloning and sequencing of an operon, carRS of Azospirillum brasilense, that codes for a novel two-component regulatory system: demonstration of a positive regulatory role of carR for global control of carbohydrate catabolism. Chattopadhyay, S., Mukherjee, A., Ghosh, S. J. Bacteriol. (1994) [Pubmed]
  11. Hearing loss in patients with enlarged vestibular aqueduct: air-bone gap and audiological Bing test. Mimura, T., Sato, E., Sugiura, M., Yoshino, T., Naganawa, S., Nakashima, T. International journal of audiology. (2005) [Pubmed]
  12. 'Indolent' Waldenstrom's macroglobulinemia and a cerebrospinal fluid protein level of 16 g/L. Garderet, L., Baudel, J.L., Cervera, P., Azizi, L., Maury, E., Guidet, B., Gorin, N.C., Offenstadt, G. Eur. J. Haematol. (2006) [Pubmed]
  13. Some tuning fork tests revisited. Golabek, W., Stephens, S.D. Clinical otolaryngology and allied sciences. (1979) [Pubmed]
  14. Franklin Church Bing (1902-1988). Darby, W.J., Swan, P.B. J. Nutr. (2001) [Pubmed]
  15. Richard J. Bing, Charles A Lindbergh, and cardiopulmonary bypass. Cheng, T.O. Am. J. Cardiol. (2000) [Pubmed]
  16. Medical and health care Qigong (Qu Bing Yang Sheng Gong). Wang, C., Xu, D., Qian, Y. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine. (1991) [Pubmed]
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