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Gene Review

serC  -  3-phosphoserine/phosphohydroxythreonine...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0898, JW0890, pdxC, pdxF
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Disease relevance of serC

  • All six recombinant plasmids which complemented aroA also complemented the serC mutation in E. coli K-12 strain KL282 [1].
  • Genes aroA and serC of Salmonella typhimurium constitute an operon [2].
  • Genetic analyses by Hfr conjugation and P1 phage transduction indicate that the mutation affecting S1 (rpsA) is located close to the serC gene [20 min on the E. coli genetic map of Bachmann et al. (1976)], with a co-transduction frequency of 61% [3].

High impact information on serC


Chemical compound and disease context of serC


Biological context of serC


Associations of serC with chemical compounds


  1. Cloning and characterisation of the serC and aroA genes of Yersinia enterocolitica, and construction of an aroA mutant. O'Gaora, P., Maskel, D., Coleman, D., Cafferkey, M., Dougan, G. Gene (1989) [Pubmed]
  2. Genes aroA and serC of Salmonella typhimurium constitute an operon. Hoiseth, S.K., Stocker, B.A. J. Bacteriol. (1985) [Pubmed]
  3. Genetic analysis of a mutation affecting ribosomal protein S1 in Escherichia coli. Ono, M., Kuwano, M., Mizushima, S. Mol. Gen. Genet. (1979) [Pubmed]
  4. Crystal structure of phosphoserine aminotransferase from Escherichia coli at 2.3 A resolution: comparison of the unligated enzyme and a complex with alpha-methyl-l-glutamate. Hester, G., Stark, W., Moser, M., Kallen, J., Marković-Housley, Z., Jansonius, J.N. J. Mol. Biol. (1999) [Pubmed]
  5. The serC-aro A operon of Escherichia coli. A mixed function operon encoding enzymes from two different amino acid biosynthetic pathways. Duncan, K., Coggins, J.R. Biochem. J. (1986) [Pubmed]
  6. Biosynthesis of phosphoserine in the methanococcales. Helgad??ttir, S., Rosas-Sandoval, G., S??ll, D., Graham, D.E. J. Bacteriol. (2007) [Pubmed]
  7. Molecular cloning, characterization and expression of cDNA encoding phosphoserine aminotransferase involved in phosphorylated pathway of serine biosynthesis from spinach. Saito, K., Takagi, Y., Ling, H.C., Takahashi, H., Noji, M. Plant Mol. Biol. (1997) [Pubmed]
  8. 3-hydroxypyruvate substitutes for pyridoxine in serC mutants of Escherichia coli K-12. Shimizu, S., Dempsey, W.B. J. Bacteriol. (1978) [Pubmed]
  9. Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12. Lam, H.M., Winkler, M.E. J. Bacteriol. (1990) [Pubmed]
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