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Gene Review

ppk  -  polyphosphate kinase, component of RNA...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2497, JW2486
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Disease relevance of ppk


High impact information on ppk


Chemical compound and disease context of ppk

  • Active inclusion bodies of recombinant polyphosphate kinase were obtained by simple washing of Escherichia coli cells with nonionic detergent and then they were immobilized in agar/TiO2 beads [8].

Biological context of ppk


Anatomical context of ppk

  • PPK has been purified from overproducing cells after release from attachment to the cell outer membrane; the purified soluble PPK reassociate with cell membrane fractions [10].

Associations of ppk with chemical compounds

  • In contrast, the mutant strain carrying multiple copies of ppk and ppx produced 1/20 of the polyphosphate found in the strain carrying multiple copies of ppk only and showed no significant increase in doubling time over the same cadmium concentration range [11].

Regulatory relationships of ppk


Other interactions of ppk

  • An E. coli strain deleted for the ppk gene showed increased stability of the ompA mRNA [14].
  • In addition, a strain containing multiple copies of ppk accumulated not only a large amount of poly(P) but also recA mRNA [13].


  1. Genetically altered levels of inorganic polyphosphate in Escherichia coli. Crooke, E., Akiyama, M., Rao, N.N., Kornberg, A. J. Biol. Chem. (1994) [Pubmed]
  2. Cloning and characterization of polyphosphate kinase and exopolyphosphatase genes from Pseudomonas aeruginosa 8830. Zago, A., Chugani, S., Chakrabarty, A.M. Appl. Environ. Microbiol. (1999) [Pubmed]
  3. Cloning, sequence and characterization of the polyphosphate kinase-encoding gene (ppk) of Klebsiella aerogenes. Kato, J., Yamamoto, T., Yamada, K., Ohtake, H. Gene (1993) [Pubmed]
  4. Novel lipoprotein expressed by Neisseria meningitidis but not by Neisseria gonorrhoeae. Yang, Q.L., Tinsley, C.R., Gotschlich, E.C. Infect. Immun. (1995) [Pubmed]
  5. Inorganic polyphosphate and the induction of rpoS expression. Shiba, T., Tsutsumi, K., Yano, H., Ihara, Y., Kameda, A., Tanaka, K., Takahashi, H., Munekata, M., Rao, N.N., Kornberg, A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  6. Phosphohistidyl active sites in polyphosphate kinase of Escherichia coli. Kumble, K.D., Ahn, K., Kornberg, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  7. Inorganic polyphosphate in mammalian cells and tissues. Kumble, K.D., Kornberg, A. J. Biol. Chem. (1995) [Pubmed]
  8. Bioenergy beads: a tool for regeneration of ATP/NTP in biocatalytic synthesis. Nahálka, J., Gemeiner, P., Bucko, M., Wang, P.G. Artificial cells, blood substitutes, and immobilization biotechnology. (2006) [Pubmed]
  9. Role of GacA, LasI, RhlI, Ppk, PsrA, Vfr and ClpXP in the regulation of the stationary-phase sigma factor rpoS/RpoS in Pseudomonas. Bertani, I., Sevo, M., Kojic, M., Venturi, V. Arch. Microbiol. (2003) [Pubmed]
  10. The polyphosphate kinase gene of Escherichia coli. Isolation and sequence of the ppk gene and membrane location of the protein. Akiyama, M., Crooke, E., Kornberg, A. J. Biol. Chem. (1992) [Pubmed]
  11. Genetic manipulation of polyphosphate metabolism affects cadmium tolerance in Escherichia coli. Keasling, J.D., Hupf, G.A. Appl. Environ. Microbiol. (1996) [Pubmed]
  12. Polyphosphate kinase regulates error-prone replication by DNA polymerase IV in Escherichia coli. Stumpf, J.D., Foster, P.L. Mol. Microbiol. (2005) [Pubmed]
  13. Involvement of inorganic polyphosphate in expression of SOS genes. Tsutsumi, K., Munekata, M., Shiba, T. Biochim. Biophys. Acta (2000) [Pubmed]
  14. Polyphosphate kinase is a component of the Escherichia coli RNA degradosome. Blum, E., Py, B., Carpousis, A.J., Higgins, C.F. Mol. Microbiol. (1997) [Pubmed]
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