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Gene Review

murA  -  UDP-N-acetylglucosamine 1...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3178, JW3156, mrbA, murZ
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Disease relevance of murA


High impact information on murA


Chemical compound and disease context of murA

  • The UDP-N-acetylglucosamine 1-carboxyvinyltransferase (enolpyruvyltransferase, EC which catalyses the first committed step in the biosynthesis of the bacterial cell-wall peptidoglycan was purified to near homogeneity from Enterobacter cloacae and the NH2-terminal amino-acid sequence determined [9].

Biological context of murA


Anatomical context of murA

  • An isogenic mutant with a deletion of murA that lacked the 66-kDa cell wall hydrolase grew as long chains during exponential growth [5].

Associations of murA with chemical compounds

  • Evidence that the reaction of the UDP-N-acetylglucosamine 1-carboxyvinyltransferase proceeds through the O-phosphothioketal of pyruvic acid bound to Cys115 of the enzyme [11].


  1. MurAA, catalysing the first committed step in peptidoglycan biosynthesis, is a target of Clp-dependent proteolysis in Bacillus subtilis. Kock, H., Gerth, U., Hecker, M. Mol. Microbiol. (2004) [Pubmed]
  2. Emergence of fosfomycin-resistant isolates of Shiga-like toxin-producing Escherichia coli O26. Horii, T., Kimura, T., Sato, K., Shibayama, K., Ohta, M. Antimicrob. Agents Chemother. (1999) [Pubmed]
  3. Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries. El Zoeiby, A., Sanschagrin, F., Darveau, A., Brisson, J.R., Levesque, R.C. J. Antimicrob. Chemother. (2003) [Pubmed]
  4. Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteria. Du, W., Brown, J.R., Sylvester, D.R., Huang, J., Chalker, A.F., So, C.Y., Holmes, D.J., Payne, D.J., Wallis, N.G. J. Bacteriol. (2000) [Pubmed]
  5. Identification and characterization of a peptidoglycan hydrolase, MurA, of Listeria monocytogenes, a muramidase needed for cell separation. Carroll, S.A., Hain, T., Technow, U., Darji, A., Pashalidis, P., Joseph, S.W., Chakraborty, T. J. Bacteriol. (2003) [Pubmed]
  6. Identification of two Shigella flexneri chromosomal loci involved in intercellular spreading. Hong, M., Gleason, Y., Wyckoff, E.E., Payne, S.M. Infect. Immun. (1998) [Pubmed]
  7. In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance. McCoy, A.J., Sandlin, R.C., Maurelli, A.T. J. Bacteriol. (2003) [Pubmed]
  8. MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli. Brown, E.D., Vivas, E.I., Walsh, C.T., Kolter, R. J. Bacteriol. (1995) [Pubmed]
  9. The UDP-N-acetylglucosamine 1-carboxyvinyl-transferase of Enterobacter cloacae. Molecular cloning, sequencing of the gene and overexpression of the enzyme. Wanke, C., Falchetto, R., Amrhein, N. FEBS Lett. (1992) [Pubmed]
  10. Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase. Marquardt, J.L., Siegele, D.A., Kolter, R., Walsh, C.T. J. Bacteriol. (1992) [Pubmed]
  11. Evidence that the reaction of the UDP-N-acetylglucosamine 1-carboxyvinyltransferase proceeds through the O-phosphothioketal of pyruvic acid bound to Cys115 of the enzyme. Wanke, C., Amrhein, N. Eur. J. Biochem. (1993) [Pubmed]
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