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Gene Review

glnG  -  fused DNA-binding response regulator in...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3861, JW3839, glnT, ntrC
 
 
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Disease relevance of glnG

 

High impact information on glnG

 

Biological context of glnG

 

Associations of glnG with chemical compounds

  • We observe that glnB ntrC and glnB glnK ntrC mutant strains accumulate high levels of intracellular 2-oxoglutarate under conditions of nitrogen excess [12].
 

Regulatory relationships of glnG

  • The expression of the putA-lacZ gene was activated by CAP and repressed by the glnG gene product [13].
 

Other interactions of glnG

  • The ntrB and ntrC genes were also defined in S. typhimurium [2].
  • The role of ntrA and ntrC in A. vinelandii was established by using Tn5 insertions in the cloned genes to construct mutants by marker exchange [6].
  • Analysis of ntrC-lacZ fusions and complementation data indicate that nifR3 ntrBC constitute a single operon. nifR3-lacZ fusions are expressed only when lacZ is in the proper reading frame with the predicted nifR3 gene product [11].
  • Moreover, disruption of both the E. coli glnB and ntrC genes resulted in a complete loss of nitrogen regulation of NifA activity by NifL [12].
 

Analytical, diagnostic and therapeutic context of glnG

  • To reveal the NtrC regulon of Escherichia coli we compared mRNA levels in a mutant strain that overexpresses NtrC-activated genes [glnL(Up)] to those in a strain with an ntrC (glnG) null allele by using DNA microarrays [14].

References

  1. Complementation analysis of glnA-linked mutations which affect nitrogen fixation in Klebsiella pneumoniae. Espin, G., Alvarez-Morales, A., Merrick, M. Mol. Gen. Genet. (1981) [Pubmed]
  2. Nitrogen regulatory locus "glnR" of enteric bacteria is composed of cistrons ntrB and ntrC: identification of their protein products. McFarland, N., McCarter, L., Artz, S., Kustu, S. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  3. Two-component regulatory systems responsive to environmental stimuli share strongly conserved domains with the nitrogen assimilation regulatory genes ntrB and ntrC. Nixon, B.T., Ronson, C.W., Ausubel, F.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  4. The ntrBC genes of Rhizobium leguminosarum are part of a complex operon subject to negative regulation. Patriarca, E.J., Riccio, A., Taté, R., Colonna-Romano, S., Iaccarino, M., Defez, R. Mol. Microbiol. (1993) [Pubmed]
  5. Nucleotide sequence of the Vibrio alginolyticus glnA region. Maharaj, R., Rumbak, E., Jones, W.A., Robb, S.M., Robb, F.T., Woods, D.R. Arch. Microbiol. (1989) [Pubmed]
  6. Regulation of nitrogen metabolism in Azotobacter vinelandii: isolation of ntr and glnA genes and construction of ntr mutants. Toukdarian, A., Kennedy, C. EMBO J. (1986) [Pubmed]
  7. Nucleotide sequence of the glnA control region of Escherichia coli. Covarrubias, A.A., Bastarrachea, F. Mol. Gen. Genet. (1983) [Pubmed]
  8. Complementation of mutations in Escherichia coli and Bordetella pertussis by B. pertussis DNA cloned in a broad-host-range cosmid vector. Brownlie, R.M., Coote, J.G., Parton, R. J. Gen. Microbiol. (1986) [Pubmed]
  9. Effects of insertions and deletions in glnG (ntrC) of Escherichia coli on nitrogen regulator I-dependent DNA binding and transcriptional activation. Shiau, S.P., Chen, P., Reitzer, L.J. J. Bacteriol. (1993) [Pubmed]
  10. Expression and purification of glutamine synthetase cloned from Bacteroides fragilis. Southern, J.A., Parker, J.R., Woods, D.R. J. Gen. Microbiol. (1986) [Pubmed]
  11. Sequence, genetic, and lacZ fusion analyses of a nifR3-ntrB-ntrC operon in Rhodobacter capsulatus. Foster-Hartnett, D., Cullen, P.J., Gabbert, K.K., Kranz, R.G. Mol. Microbiol. (1993) [Pubmed]
  12. Role of Escherichia coli nitrogen regulatory genes in the nitrogen response of the Azotobacter vinelandii NifL-NifA complex. Reyes-Ramirez, F., Little, R., Dixon, R. J. Bacteriol. (2001) [Pubmed]
  13. Mapping of the multiple regulatory sites for putP and putA expression in the putC region of Escherichia coli. Nakao, T., Yamato, I., Anraku, Y. Mol. Gen. Genet. (1988) [Pubmed]
  14. Nitrogen regulatory protein C-controlled genes of Escherichia coli: scavenging as a defense against nitrogen limitation. Zimmer, D.P., Soupene, E., Lee, H.L., Wendisch, V.F., Khodursky, A.B., Peter, B.J., Bender, R.A., Kustu, S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
 
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