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Gene Review

PB2  -  PB2

Influenza B virus

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Disease relevance of PB2


High impact information on PB2


Biological context of PB2

  • Five loci in three RNA segments, R630 in PB2, M431 in PA and A114, H410 and T509 in NP, are sufficient to allow efficient virus growth at 25 degrees C. Substitution of these five amino acids with wt (wild type) residues completely reverted the MDV-B ca phenotype [6].
  • Consensus sequences for both wt and ca B/Ann Arbor/1/66 viral PB2, PB1, PA, NP, M, and NS genes were directly determined from vRNA using a combination of chemical and chain-termination sequencing methods [8].
  • The genome RNA segment is 2368 nucleotides in length and is capable of encoding a polymerase (PB1) protein of 752 amino acids with a calculated mol mass of 84,407 Da [9].
  • However, the agent little affected the hemagglutination and RNA-dependent RNA polymerase activities of these viruses in vitro [10].

Anatomical context of PB2

  • Moreover, it is shown that coexpression of the four recombinant core proteins in COS-1 cells reconstituted a functional polymerase capable of expressing a synthetic influenza B virus-like CAT RNA [2].

Associations of PB2 with chemical compounds

  • METHODS: Clinical diagnosis, viral isolation, hemagglutinin inhibition serology, and multiplex, reverse transcription polymerase chain reaction were used to diagnose influenza in patients enrolled in international phase 3 studies designed to investigate the efficacy and safety of an anti-influenza drug (inhaled zanamivir) [5].

Other interactions of PB2

  • Dendrogram topologies of the PB2 and PB1 genes were very similar and contrasted with that of the PA gene [11].
  • The three subunits of the polymerase and the nucleoprotein of influenza B virus are the minimum set of viral proteins required for expression of a model RNA template [2].

Analytical, diagnostic and therapeutic context of PB2

  • In a serial passage experiment yielding a high growth variant of B/Hong Kong/330/2001, mutations predicted to alter AA composition occurred only in PB2 and NP in domains predicted to relate to RNP formation and function [12].
  • We describe the characterization of two recent high growth reassortants and the application of the polymerase chain reaction to ensure their genetic identity and purity [13].


  1. Comparison of the three large polymerase proteins of influenza A, B, and C viruses. Yamashita, M., Krystal, M., Palese, P. Virology (1989) [Pubmed]
  2. The three subunits of the polymerase and the nucleoprotein of influenza B virus are the minimum set of viral proteins required for expression of a model RNA template. Jambrina, E., Bárcena, J., Uez, O., Portela, A. Virology (1997) [Pubmed]
  3. Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro. Bárcena, J., Ochoa, M., de la Luna, S., Melero, J.A., Nieto, A., Ortín, J., Portela, A. J. Virol. (1994) [Pubmed]
  4. Mutational analysis of influenza B virus RNA transcription in vitro. Lee, Y.S., Seong, B.L. J. Virol. (1996) [Pubmed]
  5. Diagnosis of influenza in the community: relationship of clinical diagnosis to confirmed virological, serologic, or molecular detection of influenza. Zambon, M., Hays, J., Webster, A., Newman, R., Keene, O. Arch. Intern. Med. (2001) [Pubmed]
  6. Genetic mapping of the cold-adapted phenotype of B/Ann Arbor/1/66, the master donor virus for live attenuated influenza vaccines (FluMist). Chen, Z., Aspelund, A., Kemble, G., Jin, H. Virology (2006) [Pubmed]
  7. A new modified DNA enzyme that targets influenza virus A mRNA inhibits viral infection in cultured cells. Takahashi, H., Hamazaki, H., Habu, Y., Hayashi, M., Abe, T., Miyano-Kurosaki, N., Takaku, H. FEBS Lett. (2004) [Pubmed]
  8. Sequence comparison of wild-type and cold-adapted B/Ann Arbor/1/66 influenza virus genes. DeBorde, D.C., Donabedian, A.M., Herlocher, M.L., Naeve, C.W., Maassab, H.F. Virology (1988) [Pubmed]
  9. Influenza B virus PB1 protein; nucleotide sequence of the genome RNA segment predicts a high degree of structural homology with the corresponding influenza A virus polymerase protein. Kemdirim, S., Palefsky, J., Briedis, D.J. Virology (1986) [Pubmed]
  10. Antiviral activity of plant flavonoid, 5,7,4'-trihydroxy-8-methoxyflavone, from the roots of Scutellaria baicalensis against influenza A (H3N2) and B viruses. Nagai, T., Suzuki, Y., Tomimori, T., Yamada, H. Biol. Pharm. Bull. (1995) [Pubmed]
  11. Phylogenetic analysis of the three polymerase genes (PB1, PB2 and PA) of influenza B virus. Hiromoto, Y., Saito, T., Lindstrom, S.E., Li, Y., Nerome, R., Sugita, S., Shinjoh, M., Nerome, K. J. Gen. Virol. (2000) [Pubmed]
  12. Mutational pattern of influenza B viruses adapted to high growth replication in embryonated eggs. Lugovtsev, V.Y., Vodeiko, G.M., Levandowski, R.A. Virus Res. (2005) [Pubmed]
  13. High growth reassortant influenza vaccine viruses: new approaches to their control. Robertson, J.S., Nicolson, C., Newman, R., Major, D., Dunleavy, U., Wood, J.M. Biologicals (1992) [Pubmed]
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