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Gene Review

trpC  -  bifunctional indole-3-glycerol phosphate...

Escherichia coli O157:H7 str. EDL933

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Disease relevance of trpC


High impact information on trpC

  • A strain of E. coli suitable for selecting and classifying active mutants by functional complementation was constructed by precise deletion of the trpC gene from the genome [3].
  • Penicillium chrysogenum has been transformed to sulfonamide resistance by vectors containing the dihydropteroate synthetase gene from plasmid R388 controlled by the promoter and terminator sequences of the P. chrysogenum trpC gene [4].
  • The trpC gene in the tryptophan biosynthetic pathway was isolated from an aflatoxigenic Aspergillus parasiticus by complementation of an Escherichia coli trpC mutant lacking phosphoribosylanthranilate isomerase (PRAI) activity [5].
  • To isolate a fungal gene encoding pisatin demethylating activity (pda), we transformed Aspergillus nidulans with a genomic library of N. haematococca DNA constructed in a cosmid which carried the A. nidulans trpC gene [6].
  • Removal of the trpC transcription and translation initiation sequences from the fusion gene abolished production of the fusion protein, showing that expression is dependent on these sequences [7].

Chemical compound and disease context of trpC

  • Hygromycin-resistant transformants were selected with plasmid pCSN43 which contains the E. coli hygromycin B phosphotransferase gene under the control of Aspergillus nidulans trpC transcription signals [8].
  • In cultures of a trpC mutant of S. venezuelae, increasing the concentration of exogenous tryptophan decreased the formation of anthranilate synthase; similar evidence of endproduct repression was obtained in a trpCER mutant of E. coli transformed with a vector containing the cloned DNA fragment from S. venezuelae [9].
  • Two trp genes, trpC and trpF, from L. casei can complement mutant alleles of the corresponding genes of E. coli [10].

Biological context of trpC


Associations of trpC with chemical compounds

  • The results show that four of the five activities examined are stable under most nongrowing conditions, whereas one activity, indoleglycerol phosphate (InGP) synthetase, carried by the trpC protein, is unstable under most conditions tested [11].
  • Experiments with antibodies to the trpC protein show that sulfate-starved and ammonium-starved cultures contain 20 to 40% less immunologically reactive trpC protein than unstarved cultures [11].


  1. Arabidopsis phosphoribosylanthranilate isomerase: molecular genetic analysis of triplicate tryptophan pathway genes. Li, J., Zhao, J., Rose, A.B., Schmidt, R., Last, R.L. Plant Cell (1995) [Pubmed]
  2. Evolutionary differences in chromosomal locations of four early genes of the tryptophan pathway in fluorescent pseudomonads: DNA sequences and characterization of Pseudomonas putida trpE and trpGDC. Essar, D.W., Eberly, L., Crawford, I.P. J. Bacteriol. (1990) [Pubmed]
  3. Mutational analysis of the active site of indoleglycerol phosphate synthase from Escherichia coli. Darimont, B., Stehlin, C., Szadkowski, H., Kirschner, K. Protein Sci. (1998) [Pubmed]
  4. Transformation of Penicillium chrysogenum to sulfonamide resistance. Carramolino, L., Lozano, M., Pérez-Aranda, A., Rubio, V., Sánchez, F. Gene (1989) [Pubmed]
  5. Cloning and characterization of the trpC gene from an aflatoxigenic strain of Aspergillus parasiticus. Horng, J.S., Linz, J.E., Pestka, J.J. Appl. Environ. Microbiol. (1989) [Pubmed]
  6. Isolation of a phytoalexin-detoxification gene from the plant pathogenic fungus Nectria haematococca by detecting its expression in Aspergillus nidulans. Weltring, K.M., Turgeon, B.G., Yoder, O.C., VanEtten, H.D. Gene (1988) [Pubmed]
  7. Expression of an Escherichia coli beta-galactosidase fusion gene in Aspergillus nidulans. van Gorcom, R.F., Pouwels, P.H., Goosen, T., Visser, J., van den Broek, H.W., Hamer, J.E., Timberlake, W.E., van den Hondel, C.A. Gene (1985) [Pubmed]
  8. Heterologous transformation of Zalerion arboricola. Kelly, R., Register, E., Sosa, M. Curr. Genet. (1994) [Pubmed]
  9. Regulation of an anthranilate synthase gene in Streptomyces venezuelae by a trp attenuator. Lin, C., Paradkar, A.S., Vining, L.C. Microbiology (Reading, Engl.) (1998) [Pubmed]
  10. Nucleotide sequences and genomic constitution of five tryptophan genes of Lactobacillus casei. Natori, Y., Kano, Y., Imamoto, F. J. Biochem. (1990) [Pubmed]
  11. Inactivation and partial degradation of phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase in nongrowing cultures of Escherichia coli. Mosteller, R.D., Nishimoto, K.R., Goldstein, R.V. J. Bacteriol. (1977) [Pubmed]
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