Chemical Compound Review:
Uroguanylin (4S)-4-[[(2S)-2-[[(2S)-2- [[(2S)-2-[[(2S)-2...
Synonyms:
AC1NUQUT, 152175-68-3
- Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. Steinbrecher, K.A., Mann, E.A., Giannella, R.A., Cohen, M.B. Gastroenterology (2001)
- Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. Shailubhai, K., Yu, H.H., Karunanandaa, K., Wang, J.Y., Eber, S.L., Wang, Y., Joo, N.S., Kim, H.D., Miedema, B.W., Abbas, S.Z., Boddupalli, S.S., Currie, M.G., Forte, L.R. Cancer Res. (2000)
- Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells. Sindiće, A., Başoglu, C., Cerçi, A., Hirsch, J.R., Potthast, R., Kuhn, M., Ghanekar, Y., Visweswariah, S.S., Schlatter, E. J. Biol. Chem. (2002)
- The molecular basis of hypertension. Garbers, D.L., Dubois, S.K. Annu. Rev. Biochem. (1999)
- Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load. Lorenz, J.N., Nieman, M., Sabo, J., Sanford, L.P., Hawkins, J.A., Elitsur, N., Gawenis, L.R., Clarke, L.L., Cohen, M.B. J. Clin. Invest. (2003)
- Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells. Pitari, G.M., Di Guglielmo, M.D., Park, J., Schulz, S., Waldman, S.A. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Regulation of intestinal uroguanylin/guanylin receptor-mediated responses by mucosal acidity. Hamra, F.K., Eber, S.L., Chin, D.T., Currie, M.G., Forte, L.R. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Uroguanylin is expressed by enterochromaffin cells in the rat gastrointestinal tract. Perkins, A., Goy, M.F., Li, Z. Gastroenterology (1997)
- Uroguanylin, an intestinal natriuretic peptide, is delivered to the kidney as an unprocessed propeptide. Moss, N.G., Fellner, R.C., Qian, X., Yu, S.J., Li, Z., Nakazato, M., Goy, M.F. Endocrinology. (2008)
- Differential display of intestinal mRNAs regulated by dietary zinc. Blanchard, R.K., Cousins, R.J. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase. Hamra, F.K., Forte, L.R., Eber, S.L., Pidhorodeckyj, N.V., Krause, W.J., Freeman, R.H., Chin, D.T., Tompkins, J.A., Fok, K.F., Smith, C.E. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Lymphoguanylin: cloning and characterization of a unique member of the guanylin peptide family. Forte, L.R., Eber, S.L., Fan, X., London, R.M., Wang, Y., Rowland, L.M., Chin, D.T., Freeman, R.H., Krause, W.J. Endocrinology (1999)
- Enterochromaffin-like cells, a cellular source of uroguanylin in rat stomach. Date, Y., Nakazato, M., Yamaguchi, H., Kangawa, K., Kinoshita, Y., Chiba, T., Ueta, Y., Yamashita, H., Matsukura, S. Endocrinology (1999)
- Salt and water homeostasis: uroguanylin is a circulating peptide hormone with natriuretic activity. Forte, L.R., Fan, X., Hamra, F.K. Am. J. Kidney Dis. (1996)
- High salt intake increases uroguanylin expression in mouse kidney. Potthast, R., Ehler, E., Scheving, L.A., Sindic, A., Schlatter, E., Kuhn, M. Endocrinology (2001)
- GCAP-II: isolation and characterization of the circulating form of human uroguanylin. Hess, R., Kuhn, M., Schulz-Knappe, P., Raida, M., Fuchs, M., Klodt, J., Adermann, K., Kaever, V., Cetin, Y., Forssmann, W.G. FEBS Lett. (1995)
- The uroguanylin gene (Guca1b) is linked to guanylin (Guca2) on mouse chromosome 4. Whitaker, T.L., Steinbrecher, K.A., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Cohen, M.B. Genomics (1997)
- Uroguanylin and guanylate cyclase C in the human pancreas: expression and mutuality of ligand/receptor localization as indicators of intercellular paracrine signaling pathways. Kulaksiz, H., Cetin, Y. J. Endocrinol. (2001)
- Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency. Blanchard, R.K., Moore, J.B., Green, C.L., Cousins, R.J. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics. Forte, L.R. Pharmacol. Ther. (2004)