The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

SLCO2B1  -  solute carrier organic anion transporter...

Homo sapiens

Synonyms: KIAA0880, OATP-B, OATP-RP2, OATP2B1, OATPB, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of SLCO2B1

 

High impact information on SLCO2B1

  • OATP-B also transported estrone-3-sulfate but not bile salts [3].
  • CONCLUSIONS: OATP-B is the third bromosulphophthalein uptake system localized at the basolateral membrane of human hepatocytes [3].
  • METHODS: Tissue distribution and hepatocellular localization of OATP-B were analyzed by Northern blotting and immunofluorescence, respectively [3].
  • Approximate K(i) values were 2 micromol/L for OATP-C, 3 micromol/L for OATP8, 3 micromol/L for OATP-B and 11 micromol/L for OATP-A [4].
  • Although the expression of some members of this group, such as organic anion transporting polypeptide (OATP)-A or C, is limited to special tissues (such as liver or brain), the organic anion transporting polypeptide 2B1 (OATPB/SLCO2B1) is expressed in many organs, including liver, placenta, mammary gland, brain, and intestine [5].
 

Biological context of SLCO2B1

 

Anatomical context of SLCO2B1

 

Associations of SLCO2B1 with chemical compounds

 

Other interactions of SLCO2B1

 

Analytical, diagnostic and therapeutic context of SLCO2B1

References

  1. ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. Bronger, H., König, J., Kopplow, K., Steiner, H.H., Ahmadi, R., Herold-Mende, C., Keppler, D., Nies, A.T. Cancer Res. (2005) [Pubmed]
  2. The role of STS and OATP-B mRNA expression in predicting the clinical outcome in human breast cancer. Al Sarakbi, W., Mokbel, R., Salhab, M., Jiang, W.G., Reed, M.J., Mokbel, K. Anticancer Res. (2006) [Pubmed]
  3. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Kullak-Ublick, G.A., Ismair, M.G., Stieger, B., Landmann, L., Huber, R., Pizzagalli, F., Fattinger, K., Meier, P.J., Hagenbuch, B. Gastroenterology (2001) [Pubmed]
  4. Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Vavricka, S.R., Van Montfoort, J., Ha, H.R., Meier, P.J., Fattinger, K. Hepatology (2002) [Pubmed]
  5. Modification of OATP2B1-Mediated Transport by Steroid Hormones. Grube, M., K??ck, K., Karner, S., Reuther, S., Ritter, C.A., Jedlitschky, G., Kroemer, H.K. Mol. Pharmacol. (2006) [Pubmed]
  6. Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. Nozawa, T., Nakajima, M., Tamai, I., Noda, K., Nezu, J., Sai, Y., Tsuji, A., Yokoi, T. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  7. Down-regulation of messenger ribonucleic acid encoding an importer of sulfoconjugated steroids during human chorionic gonadotropin-induced follicular luteinization in vivo. Brown, K.A., Bouchard, N., Lussier, J.G., Sirois, J. J. Steroid Biochem. Mol. Biol. (2007) [Pubmed]
  8. Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta. St-Pierre, M.V., Hagenbuch, B., Ugele, B., Meier, P.J., Stallmach, T. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  9. Identification of steroid sulfate transport processes in the human mammary gland. Pizzagalli, F., Varga, Z., Huber, R.D., Folkers, G., Meier, P.J., St-Pierre, M.V. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  10. Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells. Sai, Y., Kaneko, Y., Ito, S., Mitsuoka, K., Kato, Y., Tamai, I., Artursson, P., Tsuji, A. Drug Metab. Dispos. (2006) [Pubmed]
  11. Characterization of human OATP2B1 (SLCO2B1) gene promoter regulation. Maeda, T., Hirayama, M., Higashi, R., Sato, M., Tamai, I. Pharm. Res. (2006) [Pubmed]
  12. Organic Anion Transporting Polypeptide 2B1 and Breast Cancer Resistance Protein Interact in the Transepithelial Transport of Steroid Sulfates in Human Placenta. Grube, M., Reuther, S., Meyer Zu Schwabedissen, H., K??ck, K., Draber, K., Ritter, C.A., Fusch, C., Jedlitschky, G., Kroemer, H.K. Drug Metab. Dispos. (2007) [Pubmed]
  13. Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium. Gao, B., Huber, R.D., Wenzel, A., Vavricka, S.R., Ismair, M.G., Remé, C., Meier, P.J. Exp. Eye Res. (2005) [Pubmed]
  14. Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1. Hänggi, E., Grundschober, A.F., Leuthold, S., Meier, P.J., St-Pierre, M.V. Mol. Pharmacol. (2006) [Pubmed]
  15. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). Niemi, M., Schaeffeler, E., Lang, T., Fromm, M.F., Neuvonen, M., Kyrklund, C., Backman, J.T., Kerb, R., Schwab, M., Neuvonen, P.J., Eichelbaum, M., Kivistö, K.T. Pharmacogenetics (2004) [Pubmed]
  16. Regional distribution of solute carrier mRNA expression along the human intestinal tract. Meier, Y., Eloranta, J.J., Darimont, J., Ismair, M.G., Hiller, C., Fried, M., Kullak-Ublick, G.A., Vavricka, S.R. Drug Metab. Dispos. (2007) [Pubmed]
  17. Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Jigorel, E., Le Vee, M., Boursier-Neyret, C., Parmentier, Y., Fardel, O. Drug Metab. Dispos. (2006) [Pubmed]
  18. Characterization and identification of steroid sulfate transporters of human placenta. Ugele, B., St-Pierre, M.V., Pihusch, M., Bahn, A., Hantschmann, P. Am. J. Physiol. Endocrinol. Metab. (2003) [Pubmed]
  19. Organic Anion Transporting Polypeptides of the OATP/SLCO Superfamily: Identification of New Members in Nonmammalian Species, Comparative Modeling and a Potential Transport Mode. Meier-Abt, F., Mokrab, Y., Mizuguchi, K. J. Membr. Biol. (2006) [Pubmed]
  20. Drug-drug interaction between pitavastatin and various drugs via OATP1B1. Hirano, M., Maeda, K., Shitara, Y., Sugiyama, Y. Drug Metab. Dispos. (2006) [Pubmed]
 
WikiGenes - Universities