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Chemical Compound Review

Danofloxacin     1-cyclopropyl-6-fluoro-7- [(1S,4S)-3-methyl...

Synonyms: Danofloxacine, Danofloxacino, Danofloxacinum, Advocin®, Advocin (TN), ...
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Disease relevance of Danofloxacin


High impact information on Danofloxacin


Chemical compound and disease context of Danofloxacin


Biological context of Danofloxacin

  • Hence, danofloxacin (Advocin, 2c) (originally CP-76,136, 1-cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1] hept-2-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid) was selected as a candidate for development as a therapeutic antibacterial agent for veterinary medicine [9].
  • Conversely, danofloxacin utility by the i.g. route was limited by low bioavailability [10].
  • This review summarizes recent studies in four ruminant species (calf, sheep, goat and camel) which have used PK-PD integration to determine for the fluoroquinolone, danofloxacin, AUC/MIC ratios producing (a) bacteriostasis (b) bactericidal activity and (c) elimination of bacteria [11].
  • Protein binding of danofloxacin was 49% in plasma, 31% in bronchial secretions, and 14% in nasal secretions, resulting in consistently higher free danoflaxacin concentrations in bronchial secretions than in plasma [12].
  • Microbial models of soil metabolism: biotransformations of danofloxacin [13].

Anatomical context of Danofloxacin


Associations of Danofloxacin with other chemical compounds


Analytical, diagnostic and therapeutic context of Danofloxacin


  1. Pharmacokinetic and pharmacodynamic profiles of danofloxacin administered by two dosing regimens in calves infected with Mannheimia (Pasteurella) haemolytica. Sarasola, P., Lees, P., AliAbadi, F.S., McKellar, Q.A., Donachie, W., Marr, K.A., Sunderland, S.J., Rowan, T.G. Antimicrob. Agents Chemother. (2002) [Pubmed]
  2. Sensitization of bacteria to danofloxacin by temperate prophages. Froshauer, S., Silvia, A.M., Chidambaram, M., Sharma, B., Weinstock, G.M. Antimicrob. Agents Chemother. (1996) [Pubmed]
  3. Comparative mutant prevention concentrations of pradofloxacin and other veterinary fluoroquinolones indicate differing potentials in preventing selection of resistance. Wetzstein, H.G. Antimicrob. Agents Chemother. (2005) [Pubmed]
  4. Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids. Aliabadi, F.S., Landoni, M.F., Lees, P. Antimicrob. Agents Chemother. (2003) [Pubmed]
  5. Predicting injection site muscle damage. II: Evaluation of extended release parenteral formulations in animal models. Sutton, S.C., Evans, L.A., Rinaldi, M.T., Norton, K.A. Pharm. Res. (1996) [Pubmed]
  6. Comparison of pharmacokinetics of danofloxacin and enrofloxacin in calves challenged with Mannheimia haemolytica. TerHune, T.N., Skogerboe, T.L., Shostrom, V.K., Weigel, D.J. Am. J. Vet. Res. (2005) [Pubmed]
  7. Efficacy of danofloxacin and tylosin in the control of mycoplasmosis in chicks infected with tylosin-susceptible or tylosin-resistant field isolates of Mycoplasma gallisepticum. Migaki, T.T., Avakian, A.P., Barnes, H.J., Ley, D.H., Tanner, A.C., Magonigle, R.A. Avian Dis. (1993) [Pubmed]
  8. Effect of danofloxacin and tilmicosin on body temperatures of beef calves with pneumonia experimentally induced by inoculation with Mannheimia haemolytica. Fajt, V.R., Apley, M.D., Brogden, K.A., Skogerboe, T.L., Shostrom, V.K., Chin, Y.L. Am. J. Vet. Res. (2004) [Pubmed]
  9. Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine. McGuirk, P.R., Jefson, M.R., Mann, D.D., Elliott, N.C., Chang, P., Cisek, E.P., Cornell, C.P., Gootz, T.D., Haskell, S.L., Hindahl, M.S. J. Med. Chem. (1992) [Pubmed]
  10. Pharmacokinetics of danofloxacin in horses after intravenous, intramuscular and intragastric administration. Fernández-Varón, E., Ayala, I., Marín, P., Carrión, A., Martos, N., Escudero, E., Cárceles, C.M. Equine Vet. J. (2006) [Pubmed]
  11. Rational dosing of antimicrobial drugs: animals versus humans. Lees, P., Shojaee Aliabadi, F. Int. J. Antimicrob. Agents (2002) [Pubmed]
  12. Penetration of danofloxacin into the respiratory tract tissues and secretions in calves. Friis, C. Am. J. Vet. Res. (1993) [Pubmed]
  13. Microbial models of soil metabolism: biotransformations of danofloxacin. Chen, Y., Rosazza, J.P., Reese, C.P., Chang, H.Y., Nowakowski, M.A., Kiplinger, J.P. J. Ind. Microbiol. Biotechnol. (1997) [Pubmed]
  14. Study of danofloxacin depletion in eggs of laying hens after oral administration. Yang, G., Dong, A., Zeng, Z., Huang, X., Chen, Z. Int. J. Antimicrob. Agents (2006) [Pubmed]
  15. Pharmacokinetics and penetration of danofloxacin into the gastrointestinal tract in healthy and in Salmonella typhimurium infected pigs. Lindecrona, R.H., Friis, C., Nielsen, J.P. Res. Vet. Sci. (2000) [Pubmed]
  16. Confirmatory and quantitative analysis using experimental design for the extraction and liquid chromatography-UV, liquid chromatography-mass spectrometry and liquid chromatography-mass spectrometry/mass spectrometry determination of quinolones in turkey muscle. Clemente, M., Hermo, M.P., Barr??n, D., Barbosa, J. Journal of chromatography. A (2006) [Pubmed]
  17. Comparison of danofloxacin with baquiloprim/sulphadimidine for the treatment of experimentally induced Escherichia coli diarrhoea in calves. White, D.G., Johnson, C.K., Cracknell, V. Vet. Rec. (1998) [Pubmed]
  18. Influence of antimicrobial agents on bactericidal activity of bovine milk polymorphonuclear leukocytes. Hoeben, D., Burvenich, C., Heyneman, R. Vet. Immunol. Immunopathol. (1997) [Pubmed]
  19. In vitro activity of danofloxacin, tylosin and oxytetracycline against mycoplasmas of veterinary importance. Cooper, A.C., Fuller, J.R., Fuller, M.K., Whittlestone, P., Wise, D.R. Res. Vet. Sci. (1993) [Pubmed]
  20. Pharmacokinetics and pharmacodynamics of danofloxacin in serum and tissue fluids of goats following intravenous and intramuscular administration. Aliabadi, F.S., Lees, P. Am. J. Vet. Res. (2001) [Pubmed]
  21. Development of a method for the determination of danofloxacin in plasma by HPLC with fluorescence detection. Garcia, M.A., Solans, C., Aramayona, J.J., Rueda, S., Bregante, M.A. Biomed. Chromatogr. (2000) [Pubmed]
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