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MeSH Review

Viral Interference

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Disease relevance of Viral Interference


High impact information on Viral Interference


Biological context of Viral Interference

  • The knowledge about viral interference with MHC class I antigen presentation is not only crucial to understand the pathogenesis of viral diseases, but contributes also to the design of novel strategies to counteract the escape mechanisms utilized by viruses [9].

Anatomical context of Viral Interference

  • Resistance to ecotropic MuLVs appears to result from viral interference involving binding of the endogenously expressed Fv-4 env-encoded protein to the ecotropic receptor, although the immune system also plays a role in resistance [10].

Associations of Viral Interference with chemical compounds


Gene context of Viral Interference

  • These data indicate that F12-HIV homologous viral interference is the consequence of the synergistic anti-HIV effects of Gag, Vif, and Nef proteins [14].
  • One gene correlated with the expression of an endogenous gp70 linked to the Rmcf gene and might act by viral interference [15].
  • Nevertheless, the viral interference with MHC class I complex formation was still active [16].
  • In principle, divergent views of interferon action may be reconciled to a common mode of action by postulating that viral interference results from a newly induced or activated RNase of cellular origin and proper specificity that acts to reduce the accumulation and functional capacity of newly synthesized viral RNAs, particularly mRNA [6].


  1. Human immunodeficiency virus (HIV) type 1 can superinfect HIV-2-infected cells: pseudotype virions produced with expanded cellular host range. Le Guern, M., Levy, J.A. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Pathogenicity induced by feline leukemia virus, Rickard strain, subgroup A plasmid DNA (pFRA). Chen, H., Bechtel, M.K., Shi, Y., Phipps, A., Mathes, L.E., Hayes, K.A., Roy-Burman, P. J. Virol. (1998) [Pubmed]
  3. Mechanism of interference mediated by human parainfluenza virus type 3 infection. Horga, M.A., Gusella, G.L., Greengard, O., Poltoratskaia, N., Porotto, M., Moscona, A. J. Virol. (2000) [Pubmed]
  4. TAP genes and immunity. McCluskey, J., Rossjohn, J., Purcell, A.W. Curr. Opin. Immunol. (2004) [Pubmed]
  5. Viral interference with IL-1 and toll signaling. Janeway, C., Medzhitov, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  6. Interferon action II. Membrane-bound alkaline ribonuclease activity in chick embryo cells manifesting interferon-mediated interference. Marcus, P.I., Terry, T.M., Levine, S. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  7. Viral interaction and responses in chronic hepatitis C and B coinfected patients with interferon-alpha plus ribavirin combination therapy. Chuang, W.L., Dai, C.Y., Chang, W.Y., Lee, L.P., Lin, Z.Y., Chen, S.C., Hsieh, M.Y., Wang, L.Y., Yu, M.L. Antivir. Ther. (Lond.) (2005) [Pubmed]
  8. Impaired lymphoid chemokine-mediated migration due to a block on the chemokine receptor switch in human cytomegalovirus-infected dendritic cells. Moutaftsi, M., Brennan, P., Spector, S.A., Tabi, Z. J. Virol. (2004) [Pubmed]
  9. Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transformation. Seliger, B., Ritz, U., Ferrone, S. Int. J. Cancer (2006) [Pubmed]
  10. Fv-4: identification of the defect in Env and the mechanism of resistance to ecotropic murine leukemia virus. Taylor, G.M., Gao, Y., Sanders, D.A. J. Virol. (2001) [Pubmed]
  11. Molecular characterization of the Akvr-1 restriction gene: a defective endogenous retrovirus-borne gene identical to Fv-4r. Dandekar, S., Rossitto, P., Pickett, S., Mockli, G., Bradshaw, H., Cardiff, R., Gardner, M. J. Virol. (1987) [Pubmed]
  12. Cytokine-mediated regulation of monocyte/macrophage cytotoxicity in human immunodeficiency virus-1 infection. Rossol, S., Gianni, G., Rossol-Voth, R., Gallati, H., Müller, W.E., Meyer zum Büschenfelde, K.H. Med. Microbiol. Immunol. (Berl.) (1992) [Pubmed]
  13. The mode of inhibition of herpes simplex and vesicular stomatitis ocular viral infections in the rabbit and hamster by an interferon inducer tilorone dihydrochloride. Tokumaru, T. Res. Commun. Chem. Pathol. Pharmacol. (1975) [Pubmed]
  14. gag, vif, and nef genes contribute to the homologous viral interference induced by a nonproducer human immunodeficiency virus type 1 (HIV-1) variant: identification of novel HIV-1-inhibiting viral protein mutants. D'Aloja, P., Olivetta, E., Bona, R., Nappi, F., Pedacchia, D., Pugliese, K., Ferrari, G., Verani, P., Federico, M. J. Virol. (1998) [Pubmed]
  15. Host genes conferring resistance to a central nervous system disease induced by a polytropic recombinant Friend murine retrovirus. Buller, R.S., Wehrly, K., Portis, J.L., Chesebro, B. J. Virol. (1990) [Pubmed]
  16. Cytokines restore MHC class I complex formation and control antigen presentation in human cytomegalovirus-infected cells. Hengel, H., Esslinger, C., Pool, J., Goulmy, E., Koszinowski, U.H. J. Gen. Virol. (1995) [Pubmed]
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