The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Lagomorpha

  • Strains of N. gonorrhoeae that resisted killing by human serum complement were killed by serum from rodent, lagomorph, and primate species, which cannot be readily infected experimentally with this organism and whose C4bp molecules did not bind to N. gonorrhoeae [1].
  • Characterization of the UDP-glucuronosyltransferase 1A locus in lagomorphs: evidence for duplication of the UGT1A6 gene [2].
  • Quantitative divergence analysis shows that the ancestor to rabbit psi beta 2 was active until 20-30 Myr ago, during which time the lagomorph beta-globin gene family apparently functioned without a pseudogene [3].
  • Multiple substitutions affect the phylogenetic utility of cytochrome b and 12S rDNA data: examining a rapid radiation in leporid (Lagomorpha) evolution [4].
  • The comparison of the coding sequence of the pig WAP gene to rodent or lagomorph WAP sequence already published demonstrated that only exon sequences are partially conserved [5].

Biological context of Lagomorpha


Anatomical context of Lagomorpha


Associations of Lagomorpha with chemical compounds

  • Thus FFA released in response to stressors in lagomorphs may effect short-term increases in steroid binding [10].
  • In addition, demethylation of the sulfonamide side chain of the drug is evident in rodent and lagomorph species only [11].
  • High total LDH activity enables pikas to perform short bouts of anaerobic activity, while high levels of H-LDH isozymes may serve to enhance lactate removal and decrease recovery time in animals living at high altitude [12].
  • Colorimetric detection of lagomorphs' calicivirus genomic sequences by polymerase chain reaction incorporating digoxigenin dUTP [13].
  • Between 1985 and 1994, 368 cases of rabies in rodents (95% of reports) and lagomorphs (5%) were reported to the Centers for Disease Control and Prevention, Atlanta, Georgia (USA), from 22 states [14].

Gene context of Lagomorpha

  • Analysis of IL-6 from four other lagomorph species suggests that this mutation is specific to the European rabbit [15].
  • The alpha 2C classification possibly separates, in general, human alpha 2-autoreceptors from those in lagomorph (rabbit) and rodent (rat, mouse, guinea pig) species that have been proposed to be predominantly alpha 2A or alpha 2D [16].
  • The IRBP results also offer some rare molecular support for the Glires concept, in which rodents and lagomorphs form a superordinal grouping [17].
  • The phylogenetic relationships among worldwide species of genus Ochotona were investigated by sequencing mitochondrial cytochrome b and ND4 genes [18].
  • In the intermediate lobe, the colocalization of TH- and GABA-immunoreactivities was a constant feature of the axons innervating the melanotrophic cells in all the species examined, except in the Leporidae [19].

Analytical, diagnostic and therapeutic context of Lagomorpha


  1. Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection. Ngampasutadol, J., Ram, S., Blom, A.M., Jarva, H., Jerse, A.E., Lien, E., Goguen, J., Gulati, S., Rice, P.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Characterization of the UDP-glucuronosyltransferase 1A locus in lagomorphs: evidence for duplication of the UGT1A6 gene. Li, Q., Lamb, G., Tukey, R.H. Mol. Pharmacol. (2000) [Pubmed]
  3. Rabbit globin pseudogene psi beta 2 is a hybrid of delta- and beta-globin gene sequences. Hardison, R.C., Margot, J.B. Mol. Biol. Evol. (1984) [Pubmed]
  4. Multiple substitutions affect the phylogenetic utility of cytochrome b and 12S rDNA data: examining a rapid radiation in leporid (Lagomorpha) evolution. Halanych, K.M., Robinson, T.J. J. Mol. Evol. (1999) [Pubmed]
  5. Cloning, transcription and chromosomal localization of the porcine whey acidic protein gene and its expression in HC11 cell line. Rival, S., Attal, J., Delville-Giraud, C., Yerle, M., Laffont, P., Rogel-Gaillard, C., Houdebine, L. Gene (2001) [Pubmed]
  6. The toxicological significance of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds in human adipose tissue. Byard, J.L. Journal of toxicology and environmental health. (1987) [Pubmed]
  7. Blunted hypoxic pulmonary vasoconstrictive response in the rodent Ochotona curzoniae (pika) at high altitude. Ge, R.L., Kubo, K., Kobayashi, T., Sekiguchi, M., Honda, T. Am. J. Physiol. (1998) [Pubmed]
  8. Species differences in the localization of neuropeptide FF receptors in rodent and lagomorph brain and spinal cord. Dupouy, V., Puget, A., Eschalier, A., Zajac, J.M. Peptides (1996) [Pubmed]
  9. Histochemical localization and functional significance of carbonic anhydrase in the salivary glands of some rodents and lagomorpha: an optical and electron microscopical study. Menghi, G., Bondi, A.M., Materazzi, G. Acta Histochem. (1983) [Pubmed]
  10. Increased corticosteroid binding capacity of plasma albumin but not of corticosteroid-binding globulin caused by ACTH-induced changes in free fatty acid concentrations in snowshoe hares and rabbits. Boonstra, R., Tinnikov, A.A. J. Endocrinol. (1998) [Pubmed]
  11. Disposition of sumatriptan in laboratory animals and humans. Dixon, C.M., Saynor, D.A., Andrew, P.D., Oxford, J., Bradbury, A., Tarbit, M.H. Drug Metab. Dispos. (1993) [Pubmed]
  12. Metabolic enzyme activities across an altitudinal gradient: an examination of pikas (genus Ochotona). Sheafor, B.A. J. Exp. Biol. (2003) [Pubmed]
  13. Colorimetric detection of lagomorphs' calicivirus genomic sequences by polymerase chain reaction incorporating digoxigenin dUTP. Psikal, I., Smíd, B., Kubalíková, R., Valícek, L., Rodák, L., Kosinová, E. Vet. Microbiol. (1997) [Pubmed]
  14. Surveillance and spatiotemporal associations of rabies in rodents and lagomorphs in the United States, 1985-1994. Childs, J.E., Colby, L., Krebs, J.W., Strine, T., Feller, M., Noah, D., Drenzek, C., Smith, J.S., Rupprecht, C.E. J. Wildl. Dis. (1997) [Pubmed]
  15. The complete cDNA sequences of IL-2, IL-4, IL-6 AND IL-10 from the European rabbit (Oryctolagus cuniculus). Perkins, H.D., van Leeuwen, B.H., Hardy, C.M., Kerr, P.J. Cytokine (2000) [Pubmed]
  16. Alpha 2C-adrenoceptor-modulated release of noradrenaline in human right atrium. Rump, L.C., Bohmann, C., Schaible, U., Schöllhorn, J., Limberger, N. Br. J. Pharmacol. (1995) [Pubmed]
  17. A molecular perspective on mammalian evolution from the gene encoding interphotoreceptor retinoid binding protein, with convincing evidence for bat monophyly. Stanhope, M.J., Czelusniak, J., Si, J.S., Nickerson, J., Goodman, M. Mol. Phylogenet. Evol. (1992) [Pubmed]
  18. Molecular systematics of pikas (genus Ochotona) inferred from mitochondrial DNA sequences. Yu, N., Zheng, C., Zhang, Y.P., Li, W.H. Mol. Phylogenet. Evol. (2000) [Pubmed]
  19. Systematic presence of GABA-immunoreactivity in the tubero-infundibular and tubero-hypophyseal dopaminergic axonal systems: an ultrastructural immunogold study on several mammals. Schimchowitsch, S., Vuillez, P., Tappaz, M.L., Klein, M.J., Stoeckel, M.E. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1991) [Pubmed]
  20. Variation among species in the endocrine control of mammary growth and function: the roles of prolactin, growth hormone, and placental lactogen. Forsyth, I.A. J. Dairy Sci. (1986) [Pubmed]
WikiGenes - Universities