Gene Review:
UGT1A6 - UDP glucuronosyltransferase 1 family,...
Homo sapiens
Synonyms:
GNT1, HLUGP, HLUGP1, Phenol-metabolizing UDP-glucuronosyltransferase, UDP-glucuronosyltransferase 1-6, ...
Fournel-Gigleux,
Drenth,
Jansen,
Huybers,
Bigler,
Peters,
Laheij,
Zhang,
Kurkela,
Ouzzine,
Luukkanen,
Bostick,
Potter,
Taskinen,
Potter,
Lampe,
Burchell,
Wolff,
Hirvonen,
van Oijen,
Kostiainen,
Samowitz,
Lampe,
Horner,
Levin,
Curtin,
Verheugt,
Slattery,
Fosdick,
Sweeney,
Li,
Ma,
Whitton,
Bigler,
Zeng,
Andersen,
Magdalou,
Yao,
Finel,
- Polymorphisms in genes encoding acetylsalicylic acid metabolizing enzymes are unrelated to upper gastrointestinal health in cardiovascular patients on acetylsalicylic acid. van Oijen, M.G., Huybers, S., Peters, W.H., Drenth, J.P., Laheij, R.J., Verheugt, F.W., Jansen, J.B. British journal of clinical pharmacology. (2005)
- CYP2C9 and UGT1A6 genotypes modulate the protective effect of aspirin on colon adenoma risk. Bigler, J., Whitton, J., Lampe, J.W., Fosdick, L., Bostick, R.M., Potter, J.D. Cancer Res. (2001)
- Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Nagar, S., Zalatoris, J.J., Blanchard, R.L. Pharmacogenetics (2004)
- Drug-metabolizing enzymes in pharyngeal mucosa and in oropharyngeal cancer tissue. Ullrich, D., Münzel, P.A., Beck-Gschaidmeier, S., Schröder, M., Bock, K.W. Biochem. Pharmacol. (1997)
- Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. Samowitz, W.S., Wolff, R.K., Curtin, K., Sweeney, C., Ma, K.N., Andersen, K., Levin, T.R., Slattery, M.L. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. (2006)
- UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation. Krishnaswamy, S., Hao, Q., Al-Rohaimi, A., Hesse, L.M., von Moltke, L.L., Greenblatt, D.J., Court, M.H. J. Pharmacol. Exp. Ther. (2005)
- Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis. Strassburg, C.P., Obermayer-Straub, P., Alex, B., Durazzo, M., Rizzetto, M., Tukey, R.H., Manns, M.P. Gastroenterology (1996)
- Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. Chen, S., Beaton, D., Nguyen, N., Senekeo-Effenberger, K., Brace-Sinnokrak, E., Argikar, U., Remmel, R.P., Trottier, J., Barbier, O., Ritter, J.K., Tukey, R.H. J. Biol. Chem. (2005)
- Inhibitory effect of troglitazone on glucuronidation catalyzed by human uridine diphosphate-glucuronosyltransferase 1A6. Ito, M., Yamamoto, K., Sato, H., Fujiyama, Y., Bamba, T. Eur. J. Clin. Pharmacol. (2001)
- Molecular analysis of patients of Sardinian descent with Crigler-Najjar syndrome type I. Rosatelli, M.C., Meloni, A., Faa, V., Saba, L., Crisponi, G., Clemente, M.G., Meloni, G., Piga, M.T., Cao, A. J. Med. Genet. (1997)
- Regulation of the human bilirubin UDP-glucuronosyltransferase gene. Brierley, C.H., Senafi, S.B., Clarke, D., Hsu, M.H., Johnson, E.F., Burchell, B. Adv. Enzyme Regul. (1996)
- Characterization of the UDP-glucuronosyltransferase 1A locus in lagomorphs: evidence for duplication of the UGT1A6 gene. Li, Q., Lamb, G., Tukey, R.H. Mol. Pharmacol. (2000)
- Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk. van der Logt, E.M., Bergevoet, S.M., Roelofs, H.M., van Hooijdonk, Z., te Morsche, R.H., Wobbes, T., de Kok, J.B., Nagengast, F.M., Peters, W.H. Carcinogenesis (2004)
- Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications. Ciotti, M., Marrone, A., Potter, C., Owens, I.S. Pharmacogenetics (1997)
- N-glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N_hydroxy-PhIP by specific human UDP-glucuronosyltransferases. Malfatti, M.A., Felton, J.S. Carcinogenesis (2001)
- Functions and transcriptional regulation of PAH-inducible human UDP-glucuronosyltransferases. Bock, K.W., Gschaidmeier, H., Heel, H., Lehmköster, T., Münzel, P.A., Bock-Hennig, B.S. Drug Metab. Rev. (1999)
- Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6. Krishnaswamy, S., Hao, Q., Von Moltke, L.L., Greenblatt, D.J., Court, M.H. Drug Metab. Dispos. (2004)
- Immunochemical identification of UGT isoforms in human small bowel and in caco-2 cell monolayers. Paine, M.F., Fisher, M.B. Biochem. Biophys. Res. Commun. (2000)
- Mechanism of rat UDP-glucuronosyltransferase 1A6 induction by oltipraz: evidence for a contribution of the Aryl hydrocarbon receptor pathway. Auyeung, D.J., Kessler, F.K., Ritter, J.K. Mol. Pharmacol. (2003)
- UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations. Lampe, J.W., Bigler, J., Horner, N.K., Potter, J.D. Pharmacogenetics (1999)
- The effect of valproic acid on drug and steroid glucuronidation by expressed human UDP-glucuronosyltransferases. Ethell, B.T., Anderson, G.D., Burchell, B. Biochem. Pharmacol. (2003)
- Human UDP-glucuronosyltransferase 1A1 is the primary enzyme responsible for the N-glucuronidation of N-hydroxy-PhIP in vitro. Malfatti, M.A., Felton, J.S. Chem. Res. Toxicol. (2004)
- UGT1A6 polymorphism and salicylic acid glucuronidation following aspirin. Chen, Y., Kuehl, G.E., Bigler, J., Rimorin, C.F., Schwarz, Y., Shen, D.D., Lampe, J.W. Pharmacogenet. Genomics (2007)
- Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6. Kurkela, M., Patana, A.S., Mackenzie, P.I., Court, M.H., Tate, C.G., Hirvonen, J., Goldman, A., Finel, M. Pharmacogenet. Genomics (2007)
- Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium. Strassburg, C.P., Nguyen, N., Manns, M.P., Tukey, R.H. Mol. Pharmacol. (1998)
- Glucuronidation of catechols by human hepatic, gastric, and intestinal microsomal UDP-glucuronosyltransferases (UGT) and recombinant UGT1A6, UGT1A9, and UGT2B7. Antonio, L., Xu, J., Little, J.M., Burchell, B., Magdalou, J., Radominska-Pandya, A. Arch. Biochem. Biophys. (2003)
- Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases. Luukkanen, L., Taskinen, J., Kurkela, M., Kostiainen, R., Hirvonen, J., Finel, M. Drug Metab. Dispos. (2005)
- Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases. Bachrich, T., Thalhammer, T., Jäger, W., Haslmayer, P., Alihodzic, B., Bakos, S., Hitchman, E., Senderowicz, A.M., Penner, E. Hepatology (2001)
- Subcellular expression of UGT1A6 and CYP1A1 responsible for propofol metabolism in human brain. Zhang, S.H., Li, Q., Yao, S.L., Zeng, B.X. Acta Pharmacol. Sin. (2001)
- Expression of a functionally active human hepatic UDP-glucuronosyltransferase (UGT1A6) lacking the N-terminal signal sequence in the endoplasmic reticulum. Ouzzine, M., Magdalou, J., Burchell, B., Fournel-Gigleux, S. FEBS Lett. (1999)
- Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A6 enzymes. Hanioka, N., Takeda, Y., Jinno, H., Tanaka-Kagawa, T., Naito, S., Koeda, A., Shimizu, T., Nomura, M., Narimatsu, S. Chem. Biol. Interact. (2006)