Disease relevance of Salpingitis

• Chlamydia trachomatis was isolated from 17 (24%) of 71 patients with acute salpingitis (AS) hospitalized for parenteral treatment [1].
• All seven tubes that contained hydrogel showed evidence of acute and chronic salpingitis and a foreign-body reaction [2].
• BACKGROUND AND OBJECTIVES: Infertility after murine chlamydial salpingitis can be prevented by tetracycline treatment given before or at the time of infection [3].
• There was no alteration in the frequency of hospitalized pelvic inflammatory disease (PID); salpingitis decreased over the years studied; and tubal sterilization events remained constant at around 0.9 per cent per year of women aged 15--44 [4].
• The association of salpingitis isthmica nodosa (SIN) and isthmic ectopic pregnancy was determined by review of resected tubal segments [5].

High impact information on Salpingitis

• Salpingitis developed in 6 of 20 women given penicillin plus probenecid, but in only 1 of 26 given trimethoprim-sulfamethoxazole and in none of 24 given tetracycline [6].
• Treatment successes for acute salpingitis included 10 of 10 (100 percent) treated with ciprofloxacin and 13 of 15 (87 percent) treated with clindamycin-gentamicin [7].
• Detection of novel organisms associated with salpingitis, by use of 16S rDNA polymerase chain reaction [8].
• Effects of quinolone analog CI-960 in a monkey model of Chlamydia trachomatis salpingitis [9].
• Roxithromycin treatment of mouse chlamydial salpingitis and protective effect on fertility [10].

Chemical compound and disease context of Salpingitis

• Treatment of acute salpingitis with sulbactam/ampicillin. Comparison with cefoxitin [11].
• It is concluded that sulbactam/ampicillin is an effective treatment for nonchlamydial salpingitis [11].
• Data suggested that the immunosuppression mediated by cyclophosphamide resulted in a prolonged genital tract infection and concomitant ascending infection leading to salpingitis [12].
• A total of 108 patients with acute salpingitis were hospitalized and randomized into two treatment groups: cefotetan/doxycycline (N = 54) and cefoxitin/doxycycline (N = 54) [13].
• The effect of tetracycline treatment on chlamydial salpingitis and subsequent fertility in the mouse [14].

Biological context of Salpingitis

• The underlying tubal disease (chronic salpingitis, follicular salpingitis, or salpingitis isthmica nodosa) seems to be the major factor identified that is associated with, and probably the cause for, the recurrent tubal gestation [15].
• However, in two other study patients chronic salpingitis with phagocytosis of cilia by luminal macrophages was demonstrated [16].
• Among the 19 women who were able to conceive only via a recanalized salpingitis isthmica nodosa tube, there were 6 live births (32%) and two tubal pregnancies (10%) [17].
• The ideal point would be to detect some biologic or clinical change that may lead to diagnosis such as a positive anti-Chlamydia trachomatis (CT) serology or, in the future, positive anti-CT Hsp 60 antibody could be the key to detecting and treating silent salpingitis in young women, CT being the main microorganism involved in chronic salpingitis [18].

Anatomical context of Salpingitis

• In an experimental model of acute gonococcal salpingitis, gonococcal infection of human fallopian tube mucosa resulted in increased mucosal production of TNF [19].
• We report a case of a twin pregnancy at term obtained after five multiple embryo transfers in a patient who presented diethylstilbestrol (DES)-associated cervical and uterine structural abnormalities, a septate uterus and bilateral tuberculous salpingitis [20].
• This study shows that eustachian tube dysfunction may be caused by salpingitis (acute or chronic) or adenoid or nasopharyngeal carcinoma [21].
• Peritoneal fluid leukotriene B4 and prostaglandin E2 in acute salpingitis [22].
• For most of the eccyeses, functional derangements appear likely to have been responsible more often than structural alterations of the oviducts; but possible roles for 'physiological salpingitis' in leading to tubal pregnancy may be worthy of investigation [23].

Gene context of Salpingitis

• Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion [24].
• No correlation between neutralizing sera and the risk of postabortal salpingitis was detected [25].
• All 16 patients with endosalpingiosis had inflammatory tubal disease (e.g., chronic salpingitis, hydrosalpinx, tubal pregnancy) [26].
• Women positive for both C. trachomatis and hsp60 epitope antibodies had an increased prevalence over controls of salpingitis, pelvic adhesions or history of PID (P < 0.05) [27].
• CONCLUSION(S): The presence of the major outer-membrane protein of C. trachomatis is associated with chronic salpingitis and/or salpingitis isthmica nodosa with tubal occlusion [28].

Analytical, diagnostic and therapeutic context of Salpingitis

• Sulbactam/ampicillin and cefoxitin were compared in the treatment of 20 patients with acute salpingitis diagnosed during laparoscopy [11].
• MAIN OUTCOME MEASURES: The measures chosen to achieve the objective included age, parity, size of hematosalpinx, volume of hemoperitoneum, tubal rupture, location, intrauterine device, ipsilateral and contralateral adhesions, and patient's previous history of salpingitis, EP, solitary tube, and tubal infertility [29].
• CONCLUSION: Selective salpingography allows complete tubal diagnosis in almost three fourths of patients with proximal tubal obstruction and salpingitis isthmica nodosa [17].
• Intrauterine pregnancies occur via recanalized salpingitis isthmica nodosa tubes, therefore catheter recanalization may be attempted before tubal microsurgery or IVF in patients with proximal tubal obstruction and associated salpingitis isthmica nodosa [17].

References