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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Salpingitis


High impact information on Salpingitis


Chemical compound and disease context of Salpingitis


Biological context of Salpingitis

  • The underlying tubal disease (chronic salpingitis, follicular salpingitis, or salpingitis isthmica nodosa) seems to be the major factor identified that is associated with, and probably the cause for, the recurrent tubal gestation [15].
  • However, in two other study patients chronic salpingitis with phagocytosis of cilia by luminal macrophages was demonstrated [16].
  • Among the 19 women who were able to conceive only via a recanalized salpingitis isthmica nodosa tube, there were 6 live births (32%) and two tubal pregnancies (10%) [17].
  • The ideal point would be to detect some biologic or clinical change that may lead to diagnosis such as a positive anti-Chlamydia trachomatis (CT) serology or, in the future, positive anti-CT Hsp 60 antibody could be the key to detecting and treating silent salpingitis in young women, CT being the main microorganism involved in chronic salpingitis [18].

Anatomical context of Salpingitis


Gene context of Salpingitis

  • Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion [24].
  • No correlation between neutralizing sera and the risk of postabortal salpingitis was detected [25].
  • All 16 patients with endosalpingiosis had inflammatory tubal disease (e.g., chronic salpingitis, hydrosalpinx, tubal pregnancy) [26].
  • Women positive for both C. trachomatis and hsp60 epitope antibodies had an increased prevalence over controls of salpingitis, pelvic adhesions or history of PID (P < 0.05) [27].
  • CONCLUSION(S): The presence of the major outer-membrane protein of C. trachomatis is associated with chronic salpingitis and/or salpingitis isthmica nodosa with tubal occlusion [28].

Analytical, diagnostic and therapeutic context of Salpingitis


  1. Failure of beta-lactam antibiotics to eradicate Chlamydia trachomatis in the endometrium despite apparent clinical cure of acute salpingitis. Sweet, R.L., Schachter, J., Robbie, M.O. JAMA (1983) [Pubmed]
  2. Selective tubal sterilization in rabbits: experience with a hydrogel combined with a sclerosing agent. Maubon, A.J., Thurmond, A.S., Laurent, A., Honiger, J.E., Scanlan, R.M., Rouanet, J.P. Radiology. (1994) [Pubmed]
  3. Does addition of anti-inflammatory agents to antimicrobial therapy reduce infertility after murine chlamydial salpingitis? Landers, D.V., Sung, M.L., Bottles, K., Schachter, J. Sexually transmitted diseases. (1993) [Pubmed]
  4. Ectopic pregnancies: rising incidence rates in Northern California. Shiono, P.H., Harlap, S., Pellegrin, F. American journal of public health. (1982) [Pubmed]
  5. Isthmic ectopic pregnancy and salpingitis isthmica nodosa. Homm, R.J., Holtz, G., Garvin, A.J. Fertil. Steril. (1987) [Pubmed]
  6. Effect of treatment regimens for Neisseria gonorrhoeae on simultaneous infection with Chlamydia trachomatis. Stamm, W.E., Guinan, M.E., Johnson, C., Starcher, T., Holmes, K.K., McCormack, W.M. N. Engl. J. Med. (1984) [Pubmed]
  7. Comparison of parenteral ciprofloxacin with clindamycin-gentamicin in the treatment of pelvic infection. Apuzzio, J.J., Stankiewicz, R., Ganesh, V., Jain, S., Kaminski, Z., Louria, D. Am. J. Med. (1989) [Pubmed]
  8. Detection of novel organisms associated with salpingitis, by use of 16S rDNA polymerase chain reaction. Hebb, J.K., Cohen, C.R., Astete, S.G., Bukusi, E.A., Totten, P.A. J. Infect. Dis. (2004) [Pubmed]
  9. Effects of quinolone analog CI-960 in a monkey model of Chlamydia trachomatis salpingitis. Patton, D.L., Cosgrove, Y.T., Kuo, C.C., Campbell, L.A. Antimicrob. Agents Chemother. (1993) [Pubmed]
  10. Roxithromycin treatment of mouse chlamydial salpingitis and protective effect on fertility. Zana, J., Muffat-Joly, M., Thomas, D., Orfila, J., Salat-Baroux, J., Pocidalo, J.J. Antimicrob. Agents Chemother. (1991) [Pubmed]
  11. Treatment of acute salpingitis with sulbactam/ampicillin. Comparison with cefoxitin. Bruhat, M.A., Pouly, J.L., Le Boedec, G., Mage, G. Drugs (1986) [Pubmed]
  12. Experimental chlamydial salpingitis in immunosuppressed guinea pigs infected in the genital tract with the agent of guinea pig inclusion conjunctivitis. White, H.J., Rank, R.G., Soloff, B.L., Barron, A.L. Infect. Immun. (1979) [Pubmed]
  13. Comparison of cefotetan plus doxycycline with cefoxitin plus doxycycline in the inpatient treatment of acute salpingitis. Walker, C.K., Landers, D.V., Ohm-Smith, M.J., Robbie, M.O., Luft, J., Schachter, J., Sweet, R.L. Sexually transmitted diseases. (1991) [Pubmed]
  14. The effect of tetracycline treatment on chlamydial salpingitis and subsequent fertility in the mouse. Swenson, C.E., Sung, M.L., Schachter, J. Sexually transmitted diseases. (1986) [Pubmed]
  15. Histopathology of fallopian tubes with recurrent tubal pregnancy. Stock, R.J. Obstetrics and gynecology. (1990) [Pubmed]
  16. Oviductal cilial phagocytosis in patients undergoing tubal reanastomosis. Silva, P.D., Silva, D.G., de la Maza, L.M., Peterson, E.M., Stone, S.C. Fertil. Steril. (1987) [Pubmed]
  17. Salpingitis isthmica nodosa: results of transcervical fluoroscopic catheter recanalization. Thurmond, A.S., Burry, K.A., Novy, M.J. Fertil. Steril. (1995) [Pubmed]
  18. PID: clinical and laparoscopic aspects. Henry-Suchet, J. Ann. N. Y. Acad. Sci. (2000) [Pubmed]
  19. Local induction of tumor necrosis factor as a molecular mechanism of mucosal damage by gonococci. McGee, Z.A., Clemens, C.M., Jensen, R.L., Klein, J.J., Barley, L.R., Gorby, G.L. Microb. Pathog. (1992) [Pubmed]
  20. Diethylstilbestrol-induced müllerian abnormalities, septate uterus, genital tuberculosis and twin pregnancy with term delivery after in-vitro fertilization. Balasch, J., Coll, O., Jové, I., Moreno, V., Mulet, J., Vanrell, J.A. Hum. Reprod. (1991) [Pubmed]
  21. Flexible endoscopy and radiologic evaluation of the eustachian tube in adults with eustachian tube dysfunction. Gaafar, H., el Deeb, A.K., Abdel-Baki, F., el-Henawi, D. The American journal of otology. (1988) [Pubmed]
  22. Peritoneal fluid leukotriene B4 and prostaglandin E2 in acute salpingitis. Heinonen, P.K., Aine, R., Seppälä, E. Gynecol. Obstet. Invest. (1990) [Pubmed]
  23. Tubal pregnancy in a 'low-risk' population: occasional association with follicular salpingitis. Campbell, J.S., Krongold, I., Bell, M.E., Fergusson, J.P. Eur. J. Obstet. Gynecol. Reprod. Biol. (1977) [Pubmed]
  24. Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion. Dieterle, S., Wollenhaupt, J. Hum. Reprod. (1996) [Pubmed]
  25. Postabortal Chlamydia trachomatis salpingitis: correlating risk with antigen-specific serological responses and with neutralization. Brunham, R.C., Peeling, R., Maclean, I., McDowell, J., Persson, K., Osser, S. J. Infect. Dis. (1987) [Pubmed]
  26. Endosalpingiosis in the omentum: a study of autopsy and surgical material. Zinsser, K.R., Wheeler, J.E. Am. J. Surg. Pathol. (1982) [Pubmed]
  27. Serological responses of patients with ectopic pregnancy to epitopes of the Chlamydia trachomatis 60 kDa heat shock protein. Sziller, I., Witkin, S.S., Ziegert, M., Csapó, Z., Ujházy, A., Papp, Z. Hum. Reprod. (1998) [Pubmed]
  28. Presence of the major outer-membrane protein of Chlamydia trachomatis in patients with chronic salpingitis and salpingitis isthmica nodosa with tubal occlusion. Dieterle, S., Rummel, C., Bader, L.W., Petersen, H., Fenner, T. Fertil. Steril. (1998) [Pubmed]
  29. Multifactorial analysis of fertility after conservative laparoscopic treatment of ectopic pregnancy in a series of 223 patients. Pouly, J.L., Chapron, C., Manhes, H., Canis, M., Wattiez, A., Bruhat, M.A. Fertil. Steril. (1991) [Pubmed]
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