Disease relevance of Still's Disease, Adult-Onset

• Coexistence of adult onset Still's disease and polymyositis with rhabdomyolysis successfully treated with methotrexate and corticosteroids [1].
• High toxicity of sulfasalazine in adult-onset Still's disease [2].
• We report on a patient who developed inappropriate secretion of antidiuretic hormone (SIADH) during the course of adult onset Still's disease (AOSD) [3].
• Whipple's disease, familial Mediterranean fever, adult-onset Still's disease, and enteropathic arthritis [4].
• Pure red cell aplasia (PRCA) associated with adult-onset Still's disease (AOSD) is very rare [5].

High impact information on Still's Disease, Adult-Onset

• TNFalpha and response of treatment-resistant adult-onset Still's disease to thalidomide [6].
• OBJECTIVE: To investigate the association of intercellular adhesion molecule 1 (ICAM-1) with clinical manifestations and interleukin-18 (IL-18) levels in patients with active untreated adult-onset Still's disease (AOSD) [7].
• OBJECTIVE: To assess the efficacy of anakinra treatment in patients with adult-onset Still's disease (AOSD) that is refractory to corticosteroids, methotrexate (MTX), and etanercept [8].
• The hyper-IgD syndrome is distinct from other periodic fever syndromes like systemic-onset juvenile rheumatoid arthritis, adult-onset Still disease, and familial Mediterranean fever [9].
• High serum level of macrophage-colony stimulating factor (M-CSF) in adult-onset Still's disease [10].

Chemical compound and disease context of Still's Disease, Adult-Onset

• OBJECTIVE: To evaluate methotrexate treatment in patients with active adult onset Still's disease (AOSD) [11].
• Cyclosporin A in the treatment of adult onset Still's disease [12].
• She was diagnosed with adult-onset Still disease and started on prednisone, with immediate improvement, delivering a viable infant at 41 weeks' gestation [13].
• A diagnosis was made of adult-onset Still disease (AOSD) presenting with acute hepatitis and very high serum ferritin levels (32,240 ng/mL), and she was treated with 2 courses of pulse therapy of methylprednisolone (2 g/day for 3 days) followed by 40 mg/day prednisolone [14].
• Isotretinoin-induced adult onset Still's disease [15].

Gene context of Still's Disease, Adult-Onset

• Recently, we reported that serum concentration of IL-18 is strikingly high in patients with adult-onset Still's disease (AOSD) [16].
• Clinical efficacy of tocilizumab in RA, soJIA, adult-onset Still's disease or CD patients has been discussed in this review [17].
• CD4 and CD8 coexpressed T-lymphocytosis in adult onset Still's disease [18].
• Main laboratory data included the following: WBC 17,100/mm, GOT 58 U, GPT 47 U, LDH 1,510 U, ferritin 19,000 ng/ml, adenosine deaminase 79.1 U/l. She was diagnosed as having adult-onset Still's disease [19].
• Infliximab has also been shown to be effective in patients with other rheumatic diseases, including ankylosing spondylitis, and may be effective in adult-onset Still's disease, polymyositis, and Behçet's disease [20].

References