The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Whipple Disease

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Whipple Disease


High impact information on Whipple Disease

  • The 16S ribosomal RNA gene of the cultured bacterium was identical to the sequence for Tropheryma whippelii identified previously in tissue samples from patients with Whipple's disease [6].
  • The bacterial 16S ribosomal RNA (rRNA) sequence was amplified directly from tissues of five unrelated patients with Whipple's disease by means of the polymerase chain reaction, first with broad-range primers and then with specific primers [7].
  • Before therapy, DNA of T. whippelii was detected in all 30 patients with Whipple's disease from whom formalin-fixed biopsy material was available, whereas Bouin-fixed material was negative [8].
  • Polymerase chain reaction of cerebrospinal fluid to diagnose Whipple's disease [9].
  • We report a patient with Whipple's disease who was treated with TMP-SMX and presented 14 months after initiation of therapy with visual decline and severe headaches [10].

Chemical compound and disease context of Whipple Disease


Biological context of Whipple Disease


Anatomical context of Whipple Disease


Gene context of Whipple Disease


Analytical, diagnostic and therapeutic context of Whipple Disease


  1. Inferior vena cava obstruction in Whipple disease. Association with retroperitoneal lymphadenopathy. Maas, L.C., Liu, H., Gelzayd, E.A. JAMA (1976) [Pubmed]
  2. Slow bacterial infections or autoimmunity? Rook, G.A., Stanford, J.L. Immunol. Today (1992) [Pubmed]
  3. De subitaneis mortibus. XIV. Bacterial arteritis in Whipple's disease. James, T.N., Haubrich, W.S. Circulation (1975) [Pubmed]
  4. Whipple disease. Clinical review of 52 cases. The SNFMI Research Group on Whipple Disease. Société Nationale Française de Médecine Interne. Durand, D.V., Lecomte, C., Cathébras, P., Rousset, H., Godeau, P. Medicine (Baltimore) (1997) [Pubmed]
  5. Immunosuppressive therapy in Whipple's disease patients is associated with the appearance of gastrointestinal manifestations. Mahnel, R., Kalt, A., Ring, S., Stallmach, A., Strober, W., Marth, T. Am. J. Gastroenterol. (2005) [Pubmed]
  6. Cultivation of the bacillus of Whipple's disease. Raoult, D., Birg, M.L., La Scola, B., Fournier, P.E., Enea, M., Lepidi, H., Roux, V., Piette, J.C., Vandenesch, F., Vital-Durand, D., Marrie, T.J. N. Engl. J. Med. (2000) [Pubmed]
  7. Identification of the uncultured bacillus of Whipple's disease. Relman, D.A., Schmidt, T.M., MacDermott, R.P., Falkow, S. N. Engl. J. Med. (1992) [Pubmed]
  8. Diagnostic application of a polymerase chain reaction assay for the Whipple's disease bacterium to intestinal biopsies. von Herbay, A., Ditton, H.J., Maiwald, M. Gastroenterology (1996) [Pubmed]
  9. Polymerase chain reaction of cerebrospinal fluid to diagnose Whipple's disease. Cohen, L., Berthet, K., Dauga, C., Thivart, L., Pierrot-Deseilligny, C. Lancet (1996) [Pubmed]
  10. Central nervous system Whipple's disease: relapse during therapy with trimethoprim-sulfamethoxazole and remission with cefixime. Cooper, G.S., Blades, E.W., Remler, B.F., Salata, R.A., Bennert, K.W., Jacobs, G.H. Gastroenterology (1994) [Pubmed]
  11. Reversal of dementia associated with Whipple's disease by trimethoprim-sulfamethoxazole, drugs that penetrate the blood-brain barrier. Ryser, R.J., Locksley, R.M., Eng, S.C., Dobbins, W.O., Schoenknecht, F.D., Rubin, C.E. Gastroenterology (1984) [Pubmed]
  12. Antibiotic treatment and relapse in Whipple's disease. Long-term follow-up of 88 patients. Keinath, R.D., Merrell, D.E., Vlietstra, R., Dobbins, W.O. Gastroenterology (1985) [Pubmed]
  13. Impaired bacterial degradation by monocytes and macrophages from a patient with treated Whipple's disease. Bjerknes, R., Laerum, O.D., Degaard, S. Gastroenterology (1985) [Pubmed]
  14. A submucosal variant of Whipple's disease. Kuhajda, F.P., Belitsos, N.J., Keren, D.F., Hutchins, G.M. Gastroenterology (1982) [Pubmed]
  15. Oculo-facial-skeletal myorhythmia in Whipple disease: treatment with ceftriaxone. Adler, C.H., Galetta, S.L. Ann. Intern. Med. (1990) [Pubmed]
  16. Detection of a clonal BCL2 gene rearrangement in tissues from a patient with Whipple disease. Fest, T., Pron, B., Lefranc, M.P., Pierre, C., Angonin, R., de Wazières, B., Soua, Z., Dupond, J.L. Ann. Intern. Med. (1996) [Pubmed]
  17. Decision analysis: an aid to the diagnosis of Whipple's disease. Olmos, M., Smecuol, E., Mauriño, E., Bai, J.C. Aliment. Pharmacol. Ther. (2006) [Pubmed]
  18. Detection of Tropheryma whippelii DNA (Whipple's disease) in faeces. Gross, M., Jung, C., Zoller, W.G. Italian journal of gastroenterology and hepatology. (1999) [Pubmed]
  19. Whipple's disease in a female with impaired cell-mediated immunity unresponsive to co-trimoxazole and levamisole therapy. Haeney, M.R., Ross, I.N. Postgraduate medical journal. (1978) [Pubmed]
  20. Whipple disease confined to the central nervous system presenting as a solitary frontal tumor. Case report. Löhr, M., Stenzel, W., Plum, G., Gross, W.P., Deckert, M., Klug, N. J. Neurosurg. (2004) [Pubmed]
  21. HLA B27 and defects in the T-cell system in Whipple's disease. Feurle, G.E., Dörken, B., Schöpf, E., Lenhard, V. Eur. J. Clin. Invest. (1979) [Pubmed]
  22. Successful treatment of Whipple disease diagnosed 36 years after symptom onset. Caples, S.M., Petrovic, L.M., Ryu, J.H. Mayo Clin. Proc. (2001) [Pubmed]
  23. A case of Whipple's disease presenting as supraclavicular lymphadenopathy. A case report. Ereño, C., Lopez, J.I., Elizalde, J.M., Ibañez, T., Fernández-Larrinoa, A., Toledo, J.D. APMIS (1993) [Pubmed]
  24. HLA antigens in Whipple's disease. Dobbins, W.O. Arthritis Rheum. (1987) [Pubmed]
  25. IL-16 is critical for Tropheryma whipplei replication in Whipple's disease. Desnues, B., Raoult, D., Mege, J.L. J. Immunol. (2005) [Pubmed]
  26. Deactivation of macrophages with interleukin-4 is the key to the isolation of Tropheryma whippelii. Schoedon, G., Goldenberger, D., Forrer, R., Gunz, A., Dutly, F., Höchli, M., Altwegg, M., Schaffner, A. J. Infect. Dis. (1997) [Pubmed]
  27. Inflammatory cell count and identification in specific duodenitis. (Celiac disease, Whipple's disease and Crohn's disease). Comparison with jejunal findings. Cheli, R., Giacosa, A. Endoscopy. (1977) [Pubmed]
  28. Response of the acute-phase reactants, C-reactive protein and serum amyloid A protein, to antibiotic treatment of Whipple's disease. Reed, J.I., Sipe, J.D., Wohlgethan, J.R., Doos, W.G., Canoso, J.J. Arthritis Rheum. (1985) [Pubmed]
  29. Vitrectomy and Whipple's disease. Durant, W.J., Flood, T., Goldberg, M.F., Tso, M.O., Pasquali, L.A., Peyman, G.A. Arch. Ophthalmol. (1984) [Pubmed]
  30. Ocular manifestations of Whipple disease: an atypical presentation. Williams, J.G., Edward, D.P., Tessler, H.H., Persing, D.H., Mitchell, P.S., Goldstein, D.A. Arch. Ophthalmol. (1998) [Pubmed]
  31. Arthralgia as an early extraintestinal symptom of Whipple's disease. Report of five cases. Schilling, D., Adamek, H.E., Kaufmann, V., Maier, M., Riemann, J.F. J. Clin. Gastroenterol. (1997) [Pubmed]
  32. Abdominal lymphomas, convulsive seizure and coma: a case of successfully treated, advanced Whipple's disease with cerebral involvement. Mohm, J., Naumann, R., Schuler, U., Ehninger, G. European journal of gastroenterology & hepatology. (1998) [Pubmed]
WikiGenes - Universities