The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Inappropriate ADH Syndrome

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Inappropriate ADH Syndrome

  • Because dDAVP acts only on the V2 receptors, these data suggest that the higher urate clearance observed during hyponatremia related to SIADH is not only the consequence of an increased "effective vascular volume," but that V1-receptor stimulation also contributes to it, by a mechanism that remains to be determined [1].
  • In 14 patients with bronchogenic carcinoma, but without overt SIADH, plasma levels of arginine vasopressin were significantly higher than in normal subjects (p less than 0.001) [2].
  • The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) occurred during an excerbation of multiple sclerosis (MS) [3].
  • The inappropriate secretion of AVP was evident in the patients with SIADH and hypopituitarism, and hydrocortisone replacement normalized urinary excretion of AQP-2 and renal water excretion in those with hypopituitarism [4].
  • Despite the mitigating effect of decreased renal sensitivity to AVP, the SIADH seen in these patients appears to contribute to the development of water intoxication caused by polydipsia [5].

High impact information on Inappropriate ADH Syndrome


Chemical compound and disease context of Inappropriate ADH Syndrome

  • As observed in the SIADH, cirrhotic patient with high FE uric acid have raised FE urea only when salt excretion is low [10].
  • Although tuberculosis is considered a cause of the syndrome of inappropriate antidiuretic hormone secretion (SIADH), circulating vasopressin has been documented in only a few cases [11].
  • More cases of SIADH with fluoxetine [12].
  • This was clearly shown during the long-term treatment of a third patient with SIADH who was taking 30 g urea/day during 11 weeks [13].
  • Although he had been taking haloperidol, the SIADH responded to fluid restriction alone [14].

Biological context of Inappropriate ADH Syndrome


Anatomical context of Inappropriate ADH Syndrome


Gene context of Inappropriate ADH Syndrome

  • Thus, V2 receptor blockade could be of interest in several water-retaining diseases such as the syndrome of inappropriate antidiuretic hormone secretion (SIADH), liver cirrhosis and congestive heart failure and deserves to be widely explored [24].
  • Either hypervolemia or hypotonicity may diminish the post-receptor signaling of AVP in renal collecting duct cells, under the chronic AVP excess state found in SIADH [15].
  • CONCLUSION: AVP-induced alterations of rBSC1 expression, as well as those of AQP2, are involved in the pathogenesis of SIADH [25].
  • We describe two infants whose clinical and laboratory evaluations were consistent with the presence of SIADH, yet who had undetectable arginine vasopressin (AVP) levels [26].
  • We have previously suggested that IL-6-stimulated AVP secretion may be the origin of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in inflammatory conditions [27].

Analytical, diagnostic and therapeutic context of Inappropriate ADH Syndrome


  1. Evidence in hyponatremia related to inappropriate secretion of ADH that V1 receptor stimulation contributes to the increase in renal uric acid clearance. Decaux, G., Namias, B., Gulbis, B., Soupart, A. J. Am. Soc. Nephrol. (1996) [Pubmed]
  2. Plasma arginine vasopressin in the syndrome of antidiuretic hormone excess associated with bronchogenic carcinoma. Padfield, P.L., Morton, J.J., Brown, J.J., Lever, A.F., Robertson, J.I., Wood, M., Fox, R. Am. J. Med. (1976) [Pubmed]
  3. The syndrome of inappropriate antidiuretic hormone secretion in multiple sclerosis. Apple, D., Kreines, K., Biehl, J.P. Arch. Intern. Med. (1978) [Pubmed]
  4. Close association of urinary excretion of aquaporin-2 with appropriate and inappropriate arginine vasopressin-dependent antidiuresis in hyponatremia in elderly subjects. Ishikawa Se, n.u.l.l., Saito, T., Fukagawa, A., Higashiyama, M., Nakamura, T., Kusaka, I., Nagasaka, S., Honda, K., Saito, T. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  5. Vasopressin in chronic psychiatric patients with primary polydipsia. Delva, N.J., Crammer, J.L., Lawson, J.S., Lightman, S.L., Sribney, M., Weier, B.J. The British journal of psychiatry : the journal of mental science. (1990) [Pubmed]
  6. High plasma atrial natriuretic peptide independent of sodium balance in SIADH. Sakamoto, H., Inoue, K., Marumo, F. JAMA (1986) [Pubmed]
  7. SIADH in a patient receiving sertraline. Bluff, D.D., Oji, N. Ann. Intern. Med. (1995) [Pubmed]
  8. Hyponatremia during therapy with amiodarone. Odeh, M., Schiff, E., Oliven, A. Arch. Intern. Med. (1999) [Pubmed]
  9. SIADH associated with fluoxetine and sertraline therapy. Jackson, C., Carson, W., Markowitz, J., Mintzer, J. The American journal of psychiatry. (1995) [Pubmed]
  10. Raised urea clearance in cirrhotic patients with high uric acid clearance is related to low salt excretion. Decaux, G., Prospert, F., Namias, B., Schlesser, M., Soupart, A. Gut (1992) [Pubmed]
  11. Altered water metabolism in tuberculosis: role of vasopressin. Hill, A.R., Uribarri, J., Mann, J., Berl, T. Am. J. Med. (1990) [Pubmed]
  12. More cases of SIADH with fluoxetine. Cohen, B.J., Mahelsky, M., Adler, L. The American journal of psychiatry. (1990) [Pubmed]
  13. Treatment of the syndrome of inappropriate secretion of antidiuretic hormone by urea. Decaux, G., Brimioulle, S., Genette, F., Mockel, J. Am. J. Med. (1980) [Pubmed]
  14. Acute psychosis, polydipsia, and inappropriate secretion of antidiuretic hormone. Kramer, D.S., Drake, M.E. Am. J. Med. (1983) [Pubmed]
  15. Role of aquaporin-2 gene expression in hyponatremic rats with chronic vasopressin-induced antidiuresis. Saito, T., Higashiyama, M., Nagasaka, S., Sasaki, S., Saito, T., Ishikawa, S.E. Kidney Int. (2001) [Pubmed]
  16. A study of serum antidiuretic hormone and atrial natriuretic peptide levels in a series of patients with intracranial disease and hyponatremia. Weinand, M.E., O'Boynick, P.L., Goetz, K.L. Neurosurgery (1989) [Pubmed]
  17. Syndrome of inappropriate antidiuretic hormone secretion following dis-dichlorodiammineplatinum II in a patient with malignant thymoma. Levin, L., Sealy, R., Barron, J. Cancer (1982) [Pubmed]
  18. Syndrome of inappropriate secretion of anti-diuretic hormone following carboplatin-paclitaxel administration in a patient with recurrent ovarian cancer. Yokoyama, Y., Shigeto, T., Futagami, M., Mizunuma, H. Eur. J. Gynaecol. Oncol. (2005) [Pubmed]
  19. Systemic lupus erythematosus and the syndrome of inappropriate secretion of antidiuretic hormone. Leventhal, L.J., Kobrin, S., Callegari, P.E. J. Rheumatol. (1991) [Pubmed]
  20. Natriuretic factors and lithium clearance in patients with the syndrome of inappropriate antidiuretic hormone (SIADH). Gross, P., Lang, R., Ketteler, M., Hausmann, C., Rascher, W., Ritz, E., Favre, H. Eur. J. Clin. Invest. (1989) [Pubmed]
  21. Hyponatremia and syndrome of inappropriate antidiuretic hormone secretion complicating stem cell transplantation. Kobayashi, R., Iguchi, A., Nakajima, M., Sato, T., Yoshida, M., Kaneda, M., Suzuki, Y., Mino, E., Kuroki, F., Kobayashi, K. Bone Marrow Transplant. (2004) [Pubmed]
  22. Two cases of MND/ALS developing the syndrome of inappropriate secretion of antidiuretic hormone. Arakawa, K., Nishio, T., Sunohara, N. Acta neurologica Scandinavica. (1997) [Pubmed]
  23. The syndrome of inappropriate ADH secretion secondary to vinblastine-bleomycin therapy. Ravikumar, T.S., Grage, T.B. Journal of surgical oncology. (1983) [Pubmed]
  24. Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Serradeil-Le Gal, C., Wagnon, J., Valette, G., Garcia, G., Pascal, M., Maffrand, J.P., Le Fur, G. Prog. Brain Res. (2002) [Pubmed]
  25. BSC1 inhibition complements effects of vasopressin V2 receptor antagonist on hyponatremia in SIADH rats. Kazama, I., Hatano, R., Michimata, M., Suzuki, K., Arata, T., Suzuki, M., Miyama, N., Sato, A., Satomi, S., Ejima, Y., Sasaki, S., Matsubara, M. Kidney Int. (2005) [Pubmed]
  26. Nephrogenic syndrome of inappropriate antidiuresis. Feldman, B.J., Rosenthal, S.M., Vargas, G.A., Fenwick, R.G., Huang, E.A., Matsuda-Abedini, M., Lustig, R.H., Mathias, R.S., Portale, A.A., Miller, W.L., Gitelman, S.E. N. Engl. J. Med. (2005) [Pubmed]
  27. Hypothalamic-pituitary-adrenal axis and interleukin-6 activity in children with head trauma and syndrome of inappropriate secretion of antidiuretic hormone. Gionis, D., Ilias, I., Moustaki, M., Mantzos, E., Papadatos, I., Koutras, D.A., Mastorakos, G. Journal of pediatric endocrinology & metabolism : JPEM. (2003) [Pubmed]
  28. Natriuresis and atrial natriuretic factor secretion during inappropriate antidiuresis. Cogan, E., Debieve, M.F., Pepersack, T., Abramow, M. Am. J. Med. (1988) [Pubmed]
  29. Syndrome of inappropriate antidiuretic hormone secretion in children following spinal fusion. Lieh-Lai, M.W., Stanitski, D.F., Sarnaik, A.P., Uy, H.G., Rossi, N.F., Simpson, P.M., Stanitski, C.L. Crit. Care Med. (1999) [Pubmed]
  30. The syndrome of inappropriate antidiuretic hormone secretion associated with induction chemotherapy for squamous cell carcinoma of the head and neck. Hayes, D.F., Lechan, R.M., Posner, M.R., Weichselbaum, R.R., Miller, D., Ervin, T.J. Journal of surgical oncology. (1986) [Pubmed]
  31. Studies of renal aquaporin-2 expression during renal escape from vasopressin-induced antidiuresis. Verbalis, J.G., Murase, T., Ecelbarger, C.A., Nielsen, S., Knepper, M.A. Adv. Exp. Med. Biol. (1998) [Pubmed]
WikiGenes - Universities