Disease relevance of Taste Disorders

• Although many of the signs of histamine release, including erythema and metallic taste, could be attenuated effectively for 6 hours with antihistamine treatment, the protection against histamine-induced flush and headache diminished after 2 hours [1].
• The most frequently reported adverse effects of metformin are gastrointestinal in nature (diarrhea, nausea, abdominal pain, and metallic taste, in decreasing order) [2].
• Patients who received plain chloroprocaine required more supplemental opioid and had a higher incidence of metallic taste and of hives than patients who received lidocaine (P < 0.05) [3].
• Amifostine is quite safe, the two major side effects are vomiting and hypotension, and the minor effects are flushing, sneezing, dizziness, chills, metallic taste etc [4].

High impact information on Taste Disorders

• Apart from a "bitter, metallic" taste in the mouth reported by 41.2% of the patients while they were receiving azelastine, no other unwanted effects were encountered [5].
• The System 22 Mizer produced more nonpulmonary (gastric and oropharyngeal) deposition of drug, more frequent local adverse effects (cough, burning in the throat, and a metallic taste), and small reductions in lung function, particularly with the 150 mg pentamidine dose [6].
• Common adverse effects of metronidazole include nausea and a metallic taste [7].
• Metallic taste was reported from stimulation with ferrous sulfate solutions, from metals and from electric stimuli [8].
• An unusual presentation of metallic taste after lidocaine injections [9].

Chemical compound and disease context of Taste Disorders

• Nausea was reported in four patients after injection of Hexabrix, and a metallic taste was significantly more frequent (p less than 0.01) with this contrast medium [10].
• Significantly more patients reported a mild, unpleasant metallic taste with grepafloxacin than with ciprofloxacin, but <1% of patients withdrew from therapy because of this [11].
• For bodily symptoms, zopiclone produced some headache, a metallic taste, and some blurring of vision; temazepam induced nausea, memory impairment and pins and needles [12].
• Two patients noted a metallic taste during the bupivacaine infusion [13].
• The only complaint from the patient, months after the osmic acid injection, was a strong metallic taste on the tongue [14].

Gene context of Taste Disorders

• Increase in GAP-43 mRNA, suggesting CT axonal regeneration, may have a role in recovery from taste disorders [15].
• Its most common side effects are gastrointestinal (nausea, diarrhea, anorexia), metallic taste, and vitamin B12 malabsorption [16].
• The examinations revealed that the incidence of smell and taste disorders in patients with allergic rhinitis is 21.4% and 31.2%, respectively [17].
• When exposing divers in-vivo to a field generated by a 200 ADC current, no symptoms other than magnetophosphenes were reported, such as metallic taste [18].
• The regression equation to estimate the frequency of taste disorders was deduced from Delta E(2), and frequency of four drugs appeared in package inserts and interview forms [19].

References