Disease relevance of OSMIUM TETROXIDE

• The role of osmic acid in the treatment of immune synovitis [1].
• We describe 4 patients successfully treated with intraarticular osmic acid for post-infectious arthritis persisting after apparent eradication of bacteria from the infected joint [2].
• Intraarticular osmic acid in postinfectious arthritis persisting after treated bacterial arthritis [2].
• After 6 months, hydrops was palpable in 8 joints treated with osmic acid and in 15 joints treated with corticosteroid only [3].
• A study of 113 knees of 72 patients treated with intra-articular injection of osmic acid for chronic exudative synovitis caused by various rheumatic diseases is reported [4].

High impact information on OSMIUM TETROXIDE

• These patients underwent the procedure after failure to respond to an intraarticular injection of either osmic acid or yttrium 90 [5].
• Thirty-seven New Zealand rabbits were observed for up to 1 year after their knee joints were instilled with 1 ml of 1% osmic acid [1].
• The osmic acid fixation-Coulter electronic counter method described for determining adipose cell size and number in intact adipose tissue fragments has been modified for use with suspensions of isolated rat and human adipose cells [6].
• Preservation for transmission electron microscopy can be accomplished with a standard glutaraldehyde fixation and osmium-tetroxide post-fixation in a suitable buffer, but again, the osmolality of the mixture must be adjusted [7].
• When such spermatozoa were placed on a grid for electron microscopy, fixed with osmic acid vapor, washed with distilled water, and negatively stained with uranyl acetate, the head of the spermatozoon was disrupted and dispersed disclosing the proximal centriole at the proximal end of the flagellum [8].

Chemical compound and disease context of OSMIUM TETROXIDE

• Intra-articular triamcinolone hexacetonide and osmic acid in persistent synovitis of the knee [9].
• One hundred mg of osmic acid (with corticosteroid and lidocaine) was injected for therapeutic purposes into the knee in 10 patients suffering from various types of recalcitrant synovitis (mostly rheumatoid arthritis) [10].

Anatomical context of OSMIUM TETROXIDE

• Fenestrations of the basal lamina of rat intestinal villi were revealed by scanning electron microscopy after removal of the overlying epithelial cells by osmic acid maceration [11].
• Serial sections, stained with osmic acid and zinc iodide, were examined from all parts of the esophagus to describe in full the innervation of opossum esophageal smooth muscle [12].
• Blood and urine examinations revealed essentially no effects of osmic acid, whereas in synovial fluid a strong inflammatory reaction was observed up to the second day after the injection, though the effusion soon disappeared [10].
• The changes in MR-determined synovial membrane volume, early synovial enhancement, and cartilage and bone erosions after osmic acid knee synovectomy were studied [13].
• Study with the electron microscope after osmic acid injection revealed necrosis of the chondrocytes in the superficial layer and upper middle zone [14].

Associations of OSMIUM TETROXIDE with other chemical compounds

• Two of these patients received one intra-articular injection of 10 ml 1% osmic acid, 5 ml 2% xylocaine and 50 mg hydrocortisone and the other 2 patients 6 ml 5% Varicocid [14].
• 43 rheumatoid knees with persistent effusion were treated by intra-articular injections of triamcinolone hexacetonide (40 mg) or combined triamcinolone - osmic acid [9].
• The sensory innervation of the rat labial mucosa was investigated by means of methylene blue vital staining and osmic acid staining [15].
• However, staining with tannic acid which forms an electron dense stain with osmic acid reveals that the phagosomes in PMN and monocytes are completely separated from the cell exterior and the cytoplasm [16].

Gene context of OSMIUM TETROXIDE

• This study presents the macroscopic and histologic results of 35 knee arthroscopies performed on patients with rheumatoid arthritis, some months after an yttrium or osmic acid intraarticular injection [17].
• Testes were removed and fixed in osmic acid [18].

Analytical, diagnostic and therapeutic context of OSMIUM TETROXIDE

• The immobilization of [3H]catecholamines in their sites of uptake and storage during post-fixation for electron microscopic processing was ensured by the use of osmic acid vapours instead of osmic acid solution [19].
• Knee arthroscopy after yttrium or osmic acid injection [17].
• Permanent effects were obtained by electrolytic lesions or by the local microinjections of 1% osmic acid [20].
• Radioactive or chemical synovectomy (synoviorthesis) is widely used as local therapy for inflammatory joint disease in France. The objective of this retrospective study was to compare the efficacy of osmic acid or radiation synovectomy with that of joint lavage for the treatment of knee osteoarthritis with effusions [21].

References