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Chemical Compound Review

IOXAGLATE SODIUM     sodium3-[2-[[3-(ethanoyl- methyl-amino)-2...

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Disease relevance of ioxaglic acid


High impact information on ioxaglic acid


Chemical compound and disease context of ioxaglic acid

  • The incidence of the combined primary endpoint of failed catheter laboratory outcome/requirement for bailout stenting/requirement for abciximab/myocardial infarction/death before hospital discharge was higher in the Visipaque group compared to the Hexabrix group (17.9% vs. 14.8%), although this did not reach statistical significance (P = 0.29) [11].
  • Death, related to abrupt occlusion of a severe left main stenosis occurred in one patient who received Hexabrix, and acute pulmonary edema occurred in one patient who received Isovue [12].
  • Thus, ischemia and reperfusion significantly dampened the coronary hemodynamic and vascular response to R76, HB, and 0.9% NaCl but not to OM [13].

Biological context of ioxaglic acid

  • There were fewer perturbations of the ECG, less alteration in the diastolic blood pressure, and no serious adverse reactions noted in the Hexabrix group [14].
  • The decreased osmotic diuresis associated with Hexabrix necessitated delayed bladder filming for optimal evaluation [15].
  • When used for IV-DSA, the lower osmolality associated with Hexabrix offers the theoretic advantages of (1) reduced osmotic load and (2) diminished alteration in central blood volume [14].
  • We prospectively examined hemodynamic, electrocardiographic, and echocardiographic indices of left ventricular function in patients undergoing contrast ventriculography with a high osmolar, ionic, monomeric contrast, diatrizoate (Renografin-76) compared with a low osmolar, ionic, dimeric contrast, ioxaglate (Hexabrix) [16].
  • In the second group, HR measured by a radioimmunoassay, and PEFR measured by a peak flowmeter were investigated after injection of Hexabrix (10 patients), Telebrix (10 patients), Omnipaque (10 patients) and Iopamiron (10 patients) [17].

Anatomical context of ioxaglic acid


Associations of ioxaglic acid with other chemical compounds


Analytical, diagnostic and therapeutic context of ioxaglic acid


  1. Contrast agent-induced thrombophlebitis following leg phlebography: meglumine loxaglate versus meglumine lothalamate. Thomas, M.L., Briggs, G.M., Kuan, B.B. Radiology. (1983) [Pubmed]
  2. A comparison of Hexabrix and Renografin 60 in peripheral arteriography. Sacks, B.A., Ellison, H.P., Bartek, S., Vine, H.S., Palestrant, A.M. Investigative radiology. (1984) [Pubmed]
  3. Omnipaque vs. Hexabrix in intravenous DSA of the carotid arteries: randomized double-blind crossover study. Nakstad, P.H., Bakke, S.J., Kjartansson, O., von Krogh, J. AJNR. American journal of neuroradiology. (1986) [Pubmed]
  4. Contrast media-induced ventricular fibrillation. A comparison of Hypaque-76, Hexabrix, and Omnipaque. Piao, Z.E., Murdock, D.K., Hwang, M.H., Raymond, R.M., Scanlon, P.J. Investigative radiology. (1988) [Pubmed]
  5. Anaphylaxis following "Hexabrix" during routine coronary angiography. Langton, J.A., Magee, P., Sedgwick, J., Sutton, R. European journal of radiology. (1988) [Pubmed]
  6. Profound platelet degranulation is an important side effect of some types of contrast media used in interventional cardiology. Chronos, N.A., Goodall, A.H., Wilson, D.J., Sigwart, U., Buller, N.P. Circulation (1993) [Pubmed]
  7. Human basophil/mast cell releasability. XI. Heterogeneity of the effects of contrast media on mediator release. Stellato, C., de Crescenzo, G., Patella, V., Mastronardi, P., Mazzarella, B., Marone, G. J. Allergy Clin. Immunol. (1996) [Pubmed]
  8. The haemodynamic effects of left ventriculography in coronary artery disease and mitral valve disease: a comparison of high and low osmolality contrast media. Fraser, A.G., Culling, W., Singh, H., Ruttley, M.S., Newcombe, R.G. Eur. Heart J. (1984) [Pubmed]
  9. Inhibition of platelet function by contrast media: iopamidol and ioxaglate versus iothalamate. Work in progress. Rao, A.K., Rao, V.M., Willis, J., Beckett, C., Steiner, R.M. Radiology. (1985) [Pubmed]
  10. Bronchial artery embolization in the management of hemoptysis: technical aspects and long-term results. Uflacker, R., Kaemmerer, A., Picon, P.D., Rizzon, C.F., Neves, C.M., Oliveira, E.S., Oliveira, M.E., Azevedo, S.N., Ossanai, R. Radiology. (1985) [Pubmed]
  11. A randomized prospective trial of ioxaglate 320 (Hexabrix) vs. iodixanol 320 (Visipaque) in patients undergoing percutaneous coronary intervention. Sutton, A.G., Ashton, V.J., Campbell, P.G., Price, D.J., Hall, J.A., de Belder, M.A. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. (2002) [Pubmed]
  12. A comparison of heparinized low osmolality ionic and nonionic contrast media in 500 patients undergoing cardiac angiography. Feldman, R.L. Clinical cardiology. (1990) [Pubmed]
  13. Effects of intracoronary administration of contrast media on coronary hemodynamics in a canine post ischemic reperfusion model. Sheu, S.H., Hwang, M.H., Piao, Z.E., Hariman, R.J., Loeb, H.S., Scanlon, P.J. Catheterization and cardiovascular diagnosis. (1991) [Pubmed]
  14. A double-blind clinical comparison of Hexabrix and Renografin-76 for intravenous digital subtraction angiography. Turski, P.A., Gentry, L.R., Matozzi, F., Verma, S. Investigative radiology. (1984) [Pubmed]
  15. Urography with a low osmolality contrast agent. Comparison of Hexabrix with Conray 325. McClennan, B.L., Ling, D., Rholl, K.S., James, M. Investigative radiology. (1986) [Pubmed]
  16. The effects of high (sodium meglumine diatrizoate, Renografin-76) and low osmolar (sodium meglumine ioxaglate, Hexabrix) radiographic contrast media on diastolic function during left ventriculography in patients. Aguirre, F.V., Pedersen, W., Castello, R., Deligonul, U., Gudipati, C., Serota, H., Labovitz, A.J., Kern, M.J. Am. Heart J. (1991) [Pubmed]
  17. Evaluation of histamine release following intravenous injection of ionic and nonionic contrast media. Pinet, A., Corot, C., Biot, N., Eloy, R. Investigative radiology. (1988) [Pubmed]
  18. Preliminary evaluation of Hexabrix for temporomandibular joint arthrography. Katzberg, R.W. Investigative radiology. (1984) [Pubmed]
  19. Effects of contrast media on porcine bone marrow-derived mononuclear cells and calf myoblast viability and secretion of VEGF and MCP-1. Baffour, R., Pakala, R., Hellinga, D., Seabron, R., Fournadjiev, J., Wolfram, R., Okubagzi, P., Epstein, S.E., Waksman, R. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. (2004) [Pubmed]
  20. The effect of Hexabrix tracheobronchography on the ultrastructure of the airway epithelium. Konrádová, V., Tůma, S., Kanta, J. Pediatric radiology. (1990) [Pubmed]
  21. A study of the effect of sodium/meglumine ioxaglate (Hexabrix) on thyroid function. Grainger, R.G., Pennington, G.W. The British journal of radiology. (1981) [Pubmed]
  22. A comparative study of contrast agents for endoscopic retrograde pancreatography. Barkin, J.S., Casal, G.L., Reiner, D.K., Goldberg, R.I., Phillips, R.S., Kaplan, S. Am. J. Gastroenterol. (1991) [Pubmed]
  23. A double-blind clinical comparison of the electrophysiologic adverse effects of Hexabrix and Renografin-76. Wolf, G.L. Investigative radiology. (1984) [Pubmed]
  24. A double-blind clinical study comparing tolerability, safety, and efficacy of Hexabrix and Renografin-76 for intravenous subtraction angiography. Nelson, J.A., Sherry, R.A. Investigative radiology. (1984) [Pubmed]
  25. Renal effects of low and isoosmolar contrast media on renal hemodynamic in a normal and ischemic dog kidney. Deray, G., Bagnis, C., Jacquiaud, C., Dubois, M., Adabra, Y., Jaudon, C. Investigative radiology. (1999) [Pubmed]
  26. High-dose clinical urography with the low-osmolality contrast agent Hexabrix: comparison with a conventional contrast agent. Spataro, R.F., Katzberg, R.W., Fischer, H.W., McMannis, M.J. Radiology. (1987) [Pubmed]
  27. Hexabrix as a contrast agent for hysterosalpingography. Winfield, A.C., Maxson, W.S., Harding, D.R., Diggs, J., Wentz, A.C. Radiology. (1984) [Pubmed]
  28. Clinical experience with Hexabrix in cerebral angiography. Robertson, W.D., Nugent, R.A., Russell, D.B., Singer-Jordan, J., Graeb, D.A., Lapointe, J.S., Morris, D.C. Investigative radiology. (1984) [Pubmed]
  29. A double-blind randomized clinical study of the use of Hexabrix in pediatric angiocardiography. Tonkin, I.L. Investigative radiology. (1984) [Pubmed]
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