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Gene Review

Ppy  -  pancreatic polypeptide

Mus musculus

Synonyms: AV061413, IGSPP, PP, Pancreatic polypeptide, Pancreatic prohormone
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Disease relevance of Ppy


Psychiatry related information on Ppy

  • The feeding response to PP family peptides were quite similar to that in locomotor activity with respect to dose-response, time course and peptide specificity [6].
  • Furthermore, PP secretion in response to CCK-8 showed a similarity with that of insulin in terms of dose- and time-response characteristics as well as sensitivity to CCKA-receptor antagonism [7].

High impact information on Ppy


Chemical compound and disease context of Ppy

  • Neuroglucopenia induced by 2-deoxy-D-glucose or insulin-induced hypoglycemia also increased plasma PP (+79 +/- 18 and +89 +/- 11 pg/ml vs. control, respectively) [3].

Biological context of Ppy


Anatomical context of Ppy


Associations of Ppy with chemical compounds


Regulatory relationships of Ppy


Other interactions of Ppy


Analytical, diagnostic and therapeutic context of Ppy


  1. Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Asakawa, A., Inui, A., Yuzuriha, H., Ueno, N., Katsuura, G., Fujimiya, M., Fujino, M.A., Niijima, A., Meguid, M.M., Kasuga, M. Gastroenterology (2003) [Pubmed]
  2. Temporal changes in pancreatic islet composition in C57BL/6J-db/db (diabetes) mice. Gapp, D.A., Leiter, E.H., Coleman, D.L., Schwizer, R.W. Diabetologia (1983) [Pubmed]
  3. Autonomic control of pancreatic polypeptide and glucagon secretion during neuroglucopenia and hypoglycemia in mice. Havel, P.J., Akpan, J.O., Curry, D.L., Stern, J.S., Gingerich, R.L., Ahren, B. Am. J. Physiol. (1993) [Pubmed]
  4. Failure of pancreatic polypeptide release in congenitally obese mice. Jia, B.Q., Taylor, I.L. Gastroenterology (1984) [Pubmed]
  5. Pancreatic polypeptide causes diarrhea and weight loss in obese mice but not in lean littermates. Mordes, J.P., Eastwood, G.L., Loo, S., Rossini, A.A. Peptides (1982) [Pubmed]
  6. Effects of pancreatic polypeptide family peptides on feeding and learning behavior in mice. Nakajima, M., Inui, A., Teranishi, A., Miura, M., Hirosue, Y., Okita, M., Himori, N., Baba, S., Kasuga, M. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  7. Effects of cholecystokinin and glucagon-like peptide 1 on the secretion of pancreatic polypeptide in mice. Ahrén, B., Gingerich, R.L., Havel, P.J. Regul. Pept. (1995) [Pubmed]
  8. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Kojima, H., Fujimiya, M., Matsumura, K., Younan, P., Imaeda, H., Maeda, M., Chan, L. Nat. Med. (2003) [Pubmed]
  9. Y4 receptor knockout rescues fertility in ob/ob mice. Sainsbury, A., Schwarzer, C., Couzens, M., Jenkins, A., Oakes, S.R., Ormandy, C.J., Herzog, H. Genes Dev. (2002) [Pubmed]
  10. Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Herrera, P.L., Huarte, J., Sanvito, F., Meda, P., Orci, L., Vassalli, J.D. Development (1991) [Pubmed]
  11. Cardiac function in neuropeptide Y Y4 receptor-knockout mice. Smith-White, M.A., Herzog, H., Potter, E.K. Regul. Pept. (2002) [Pubmed]
  12. Mechanisms of neuropeptide Y, peptide YY, and pancreatic polypeptide inhibition of identified green fluorescent protein-expressing GABA neurons in the hypothalamic neuroendocrine arcuate nucleus. Acuna-Goycolea, C., Tamamaki, N., Yanagawa, Y., Obata, K., van den Pol, A.N. J. Neurosci. (2005) [Pubmed]
  13. Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes. Herrera, P.L., Huarte, J., Zufferey, R., Nichols, A., Mermillod, B., Philippe, J., Muniesa, P., Sanvito, F., Orci, L., Vassalli, J.D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  14. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Sainsbury, A., Schwarzer, C., Couzens, M., Fetissov, S., Furtinger, S., Jenkins, A., Cox, H.M., Sperk, G., Hökfelt, T., Herzog, H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  15. Influence of glucagon, gastric inhibitory polypeptide, pancreatic polypeptide and somatostatin on beta-adrenergically induced insulin secretion in the mouse. Ahrén, B., Lundquist, I. Diabète & métabolisme. (1982) [Pubmed]
  16. Impaired glucose tolerance in pancreatic polypeptide-overexpressing mice. Ueno, N., Inui, A., Asakawa, A., Yuzuriha, H., Kasuga, M., Fujimiya, M. Diabetologia (2002) [Pubmed]
  17. Ca2+ signaling in mouse pancreatic polypeptide cells. Liu, Y.J., Hellman, B., Gylfe, E. Endocrinology (1999) [Pubmed]
  18. Expression of somatostatin receptor subtypes 1-5 in pancreatic islets of normoglycaemic and diabetic NOD mice. Ludvigsen, E., Stridsberg, M., Janson, E.T., Sandler, S. Eur. J. Endocrinol. (2005) [Pubmed]
  19. PYY in developing murine islet cells: comparisons to development of islet hormones, NPY, and BrdU incorporation. Jackerott, M., Oster, A., Larsson, L.I. J. Histochem. Cytochem. (1996) [Pubmed]
  20. Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Upchurch, B.H., Aponte, G.W., Leiter, A.B. Development (1994) [Pubmed]
  21. Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Gu, G., Brown, J.R., Melton, D.A. Mech. Dev. (2003) [Pubmed]
  22. Pancreatic spasmolytic polypeptide (PSP): III. Pharmacology of a new porcine pancreatic polypeptide with spasmolytic and gastric acid secretion inhibitory effects. Jørgensen, K.D., Diamant, B., Jørgensen, K.H., Thim, L. Regul. Pept. (1982) [Pubmed]
  23. Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: Predominant localization in pancreatic polypeptide-secreting PP-cells. Sakamoto, Y., Inoue, H., Kawakami, S., Miyawaki, K., Miyamoto, T., Mizuta, K., Itakura, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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