The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

nizatidine     (E)-N-[2-[[2- (dimethylaminomethyl)-1,3...

Synonyms: Calmaxid, Cronizat, Distaxid, Naxidine, Antizid, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of nizatidine


Psychiatry related information on nizatidine


High impact information on nizatidine

  • Nizatidine is a selective histamine2 receptor antagonist that effectively suppresses gastric acid secretion at lower than prescription doses and has been approved for nonprescription use in the prevention of postprandial heartburn [2].
  • Twelve healthy volunteers were given one week's oral treatment with each of 300 mg nizatidine, 40 mg famotidine, and placebo once daily in a randomised, placebo controlled, double blind study [4].
  • In conclusion, the effect of nizatidine in reducing the heart rate needs careful evaluation in elderly patients with heart failure or those also taking beta blockers [4].
  • The exercise heart rate on nizatidine as well as the resting heart rate on concurrent administration of nizatidine and the beta receptor blocking agent atenolol were subsequently investigated in the same volunteers [4].
  • METHODS: A patient with olanzapine temporally associated weight gain was treated with nizatidine as "add-on" therapy [11].

Chemical compound and disease context of nizatidine


Biological context of nizatidine


Anatomical context of nizatidine


Associations of nizatidine with other chemical compounds


Gene context of nizatidine


Analytical, diagnostic and therapeutic context of nizatidine


  1. Rebound nocturnal hypersecretion after four weeks treatment with an H2 receptor antagonist. Fullarton, G.M., McLauchlan, G., Macdonald, A., Crean, G.P., McColl, K.E. Gut (1989) [Pubmed]
  2. A double-blind, placebo-controlled study of the effectiveness and safety of nizatidine in the prevention of postprandial heartburn. Spiegel, J.E., Thoden, W.R., Pappas, K., Fratarcangelo, P., Furey, S.A. Arch. Intern. Med. (1997) [Pubmed]
  3. Leukocytoclastic vasculitis associated with nizatidine therapy. Suh, J.G., Oleksowicz, L., Dutcher, J.P. Am. J. Med. (1997) [Pubmed]
  4. Negative chronotropic effects of nizatidine. Halabi, A., Kirch, W. Gut (1991) [Pubmed]
  5. Nizatidine prevents peptic ulceration in high-risk patients taking nonsteroidal anti-inflammatory drugs. Levine, L.R., Cloud, M.L., Enas, N.H. Arch. Intern. Med. (1993) [Pubmed]
  6. Obstructive sleep apnea and gastroesophageal reflux. Ing, A.J., Ngu, M.C., Breslin, A.B. Am. J. Med. (2000) [Pubmed]
  7. Extrapyramidal symptoms related to adjunctive nizatidine therapy in an adolescent receiving quetiapine and paroxetine. Bhanji, N.H., Margolese, H.C. Pharmacotherapy (2004) [Pubmed]
  8. Significance of duodenogastric reflux in patients with erosive esophagitis. Simić, A., Pesko, P. Acta chirurgica Iugoslavica. (2000) [Pubmed]
  9. Effect of nizatidine on olanzapine-associated weight gain in schizophrenic patients in Korea: a pilot study. Pae, C.U., Kim, J.J., Lee, K.U., Lee, C.U., Bahk, W.M., Lee, S.J., Lee, C., Paik, I.H. Human psychopharmacology. (2003) [Pubmed]
  10. Risk factors of relapse in gastric ulcer: a one-year, double-blind, comparative study of nizatidine versus placebo. Battaglia, G. The Italian journal of gastroenterology. (1994) [Pubmed]
  11. H(2) antagonist nizatidine may control olanzapine-associated weight gain in schizophrenic patients. Sacchetti, E., Guarneri, L., Bravi, D. Biol. Psychiatry (2000) [Pubmed]
  12. Peptic ulcer in the elderly--a double-blind, short-term study comparing nizatidine 300 mg with ranitidine 300 mg. GISU (Interdisciplinary Ulcer Study Group). Battaglia, G., Di Mario, F., Vigneri, S., Dal Santo, P., Pilotto, A., Mazzacca, G. Aliment. Pharmacol. Ther. (1993) [Pubmed]
  13. Actions of nizatidine, a selective histamine H2-receptor antagonist, on gastric acid secretion in dogs, rats and frogs. Lin, T.M., Evans, D.C., Warrick, M.W., Pioch, R.P. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  14. Comparison of the efficacy of pantoprazole vs. nizatidine in the treatment of erosive oesophagitis: a randomized, active-controlled, double-blind study. Kovacs, T.O., Wilcox, C.M., DeVault, K., Miska, D., Bochenek, W. Aliment. Pharmacol. Ther. (2002) [Pubmed]
  15. Actions of nizatidine on the rat uterus, dog stomach and experimentally induced gastric lesions. Lin, T.M., Evans, D.C., Warrick, M.W., Ruffolo, R.R. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  16. Clinical experience with pantoprazole in gastroesophageal reflux disease. Avner, D.L. Clinical therapeutics. (2000) [Pubmed]
  17. Absorption studies of the H2-blocker nizatidine. Knadler, M.P., Bergstrom, R.F., Callaghan, J.T., Obermeyer, B.D., Rubin, A. Clin. Pharmacol. Ther. (1987) [Pubmed]
  18. Intravenous nizatidine kinetics and acid suppression. Callaghan, J.T., Bergstrom, R.F., Obermeyer, B.D., King, E.P., Offen, W.W. Clin. Pharmacol. Ther. (1985) [Pubmed]
  19. Nizatidine disposition in subjects with normal and impaired renal function. Aronoff, G.R., Bergstrom, R.F., Bopp, R.J., Sloan, R.S., Callaghan, J.T. Clin. Pharmacol. Ther. (1988) [Pubmed]
  20. Cimetidine inhibition of human gastric and liver alcohol dehydrogenase isoenzymes: identification of inhibitor complexes by kinetics and molecular modeling. Stone, C.L., Hurley, T.D., Peggs, C.F., Kedishvili, N.Y., Davis, G.J., Thomasson, H.R., Li, T.K., Bosron, W.F. Biochemistry (1995) [Pubmed]
  21. Gastroprokinetic activity of nizatidine, a new H2-receptor antagonist, and its possible mechanism of action in dogs and rats. Ueki, S., Seiki, M., Yoneta, T., Aita, H., Chaki, K., Hori, Y., Morita, H., Tagashira, E., Itoh, Z. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  22. Secretion of nizatidine into human breast milk after single and multiple doses. Obermeyer, B.D., Bergstrom, R.F., Callaghan, J.T., Knadler, M.P., Golichowski, A., Rubin, A. Clin. Pharmacol. Ther. (1990) [Pubmed]
  23. Carrier-mediated active transport of histamine H2 receptor antagonists, cimetidine and nizatidine, into isolated rat hepatocytes: contribution of type I system. Nakamura, H., Sano, H., Yamazaki, M., Sugiyama, Y. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  24. Twenty four hour intragastric acidity and plasma gastrin concentration in healthy volunteers taking nizatidine 150 mg, nizatidine 300 mg, ranitidine 300 mg, or placebo at 21:00 h. Lanzon-Miller, S., Pounder, R.E., Chronos, N.A., Raymond, F., Hamilton, M.R., Dalgleish, D. Gut (1988) [Pubmed]
  25. The medical management of reflux esophagitis. Role of antacids and acid inhibition. Sontag, S.J. Gastroenterol. Clin. North Am. (1990) [Pubmed]
  26. Cimetidine uptake and interactions with cationic drugs in freshly isolated proximal tubular cells of the rat. Boom, S.P., Russel, F.G. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  27. Inhibition of drug metabolism in human liver microsomes by nizatidine, cimetidine and omeprazole. Furuta, S., Kamada, E., Suzuki, T., Sugimoto, T., Kawabata, Y., Shinozaki, Y., Sano, H. Xenobiotica (2001) [Pubmed]
  28. Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide. Itoh, H., Naito, T., Takeyama, M. J. Pharm. Pharmacol. (2002) [Pubmed]
  29. H2 histamine receptor blockade in the treatment of Alzheimer disease: a randomized, double-blind, placebo-controlled trial of nizatidine. Carlson, M.C., Tschanz, J.T., Norton, M.C., Welsh-Bohmer, K., Martin, B.K., Breitner, J.C. Alzheimer disease and associated disorders. (2002) [Pubmed]
  30. Head-column field-amplified sample stacking in capillary electrophoresis for the determination of cimetidine, famotidine, nizatidine, and ranitidine-HCl in plasma. Wu, S.M., Ho, Y.H., Wu, H.L., Chen, S.H., Ko, H.S. Electrophoresis (2001) [Pubmed]
  31. A comparison of two doses of nizatidine versus placebo in the treatment of reflux oesophagitis. Quik, R.F., Cooper, M.J., Gleeson, M., Hentschel, E., Schuetze, K., Kingston, R.D., Mitchell, M. Aliment. Pharmacol. Ther. (1990) [Pubmed]
WikiGenes - Universities