Disease relevance of Choledochal Cyst

• We measured the serum AFP concentration in 52 neonates and infants with various hepatobiliary disorders, including neonatal hepatitis syndrome (group I), biliary atresia (group II), and other hepatopathies such as choledochal cyst (group III) [1].
• Possible aetiological factors were: choledochal cyst (1); parotitis without a rise in mumps antibodies (1); familial dyslipidaemia but without AP in other family members (1), and aluminium intoxication with hypercalcaemia and convulsive encephalopathy treated with valproic acid in 1 patient [2].
• CONCLUSION: Bile from congenital choledochal cyst patients can promote the proliferation of human cholangiocarcinoma QBC939 cells via COX-2 and PGE(2) pathway [3].
• Two children presenting with a triad of recurrent jaundice, fever, and abdominal pain were investigated and found to have type 1 choledochal cyst [4].
• There were seven Todani type 1 and two Todani type 5 choledochal cysts (Caroli's disease) [5].

High impact information on Choledochal Cyst

• SUMMARY BACKGROUND DATA: The typical patient with choledochal cyst disease has been the female infant with the triad of jaundice, an abdominal mass, and pain [6].
• In this work fibrillin-1 expression was studied by immunohistochemistry in liver samples from children with various cholestatic diseases corresponding to paucity of intrahepatic bile ducts, biliary atresia, congenital hepatic fibrosis, Byler's disease, mitochondrial cytopathy, sclerosing cholangitis, or choledochal cyst [7].
• Pancreatitis associated with choledochal cyst and other anomalies in childhood [8].
• Activated pancreatic enzyme and pancreatic stone protein (PSP/reg) in bile of patients with pancreaticobiliary maljunction/ choledochal cysts [9].
• Other CBD interventions that have been reported include laparoscopic biliary bypass and resection of choledochal cysts [10].

Chemical compound and disease context of Choledochal Cyst

• Choledochal cyst. Imaging by Telepaque-enhanced computed tomography [11].
• The interesting finding of her choledochal cyst, which was visualized 5 minutes after the injection of Tc-99m disofenin and contracted well after an egg meal, is reported [12].
• All children with choledochal cysts have normal bilirubin values [13].
• Surgical excision of the duodenal luminal portion of the choledochocele was the treatment most commonly used (65% of cases) [14].
• Mebrofenin scintigraphy is accurate in confirming the presence of a choledochal cyst and in refuting the diagnosis of EHBA [15].

Anatomical context of Choledochal Cyst

• Choledochal cyst with bile duct dilatation: sonography and 99mTc IDA cholescintigraphy [16].
• Choledochal cyst mimicking gallbladder in Tc-99m disofenin radionuclide cholescintigraphy [12].
• Neither the relative composition nor the absolute concentration of secondary bile acids (deoxycholic acid, lithocholic acid) elevated in patients with choledochal cyst compared with the values in the non-choledochal cyst patients with or without biliary tract carcinoma [17].

Gene context of Choledochal Cyst

• In a 12-year-old girl with adenocarcinoma arising from a choledochal cyst, K-ras and DPC-4 (homozygous deletion) mutations were identified simultaneously [18].
• Expressions of p53 and inducible nitric oxide synthase in congenital choledochal cysts [19].
• METHODS: iNOS and p53 were detected by immunohistochemistry staining in 26 patients with congenital choledochal cysts [19].
• The accurate preoperative diagnosis of choledochal cyst, made by sonography combined with 99mTc IDA cholescintigraphy, obviated invasive studies [16].
• The authors report a case of a 4-year-old girl whom on routine abdominal ultrasound as follow-up for vesicoureteral reflux was found to have a choledochal cyst [20].

Analytical, diagnostic and therapeutic context of Choledochal Cyst

• METHODS: Immunohistochemical stains of Fas and Fas ligand (FasL) and in situ hybridization of Fas ligand messenger RNA (mRNA) were performed on paraffin-embedded liver specimens of 36 biliary atresia, 6 choledochal cysts, and 14 nontumorous parts of pediatric liver tumors [21].

References