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MeSH Review

Biliary Atresia

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Disease relevance of Biliary Atresia


High impact information on Biliary Atresia

  • Here, we address the hypothesis that production of IFN-gamma is a key pathogenic mechanism of disease using a mouse model of rotavirus-induced biliary atresia [6].
  • These observations suggest that the carbohydrate-binding specificity of a virus can dramatically alter disease in the host and highlight the need for epidemiologic studies focusing on infection by sialic acid-binding reovirus strains as a possible contributor to the pathogenesis of neonatal biliary atresia [7].
  • The second was the time-restricted expression of genes regulating biological networks previously unrecognized in biliary atresia, such as the complement components C3ar-1 and C1q-alpha/beta [8].
  • No B19 DNA was detected in serum from patients with other types of FH or from 82 patients with biliary atresia [9].
  • Increased urinary dipeptidyl peptidase IV activity in extrahepatic biliary atresia [10].

Chemical compound and disease context of Biliary Atresia


Biological context of Biliary Atresia


Anatomical context of Biliary Atresia


Gene context of Biliary Atresia


Analytical, diagnostic and therapeutic context of Biliary Atresia


  1. Hepatic vitamin D 25-hydroxylase: inhibition by bile duct ligation or bile salts. Bolt, M.J., Sitrin, M.D., Favus, M.J., Rosenberg, I.H. Hepatology (1981) [Pubmed]
  2. Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration. Koniaris, L.G., Zimmers-Koniaris, T., Hsiao, E.C., Chavin, K., Sitzmann, J.V., Farber, J.M. J. Immunol. (2001) [Pubmed]
  3. One hundred nine living donor liver transplants in adults and children: a single-center experience. Miller, C.M., Gondolesi, G.E., Florman, S., Matsumoto, C., Muñoz, L., Yoshizumi, T., Artis, T., Fishbein, T.M., Sheiner, P.A., Kim-Schluger, L., Schiano, T., Shneider, B.L., Emre, S., Schwartz, M.E. Ann. Surg. (2001) [Pubmed]
  4. The human Delta-like 1 homologue is implicated in the progression of liver fibrosis in biliary atresia. Huang, C.C., Chuang, J.H., Huang, L.L., Chou, M.H., Wu, C.L., Chen, C.M., Hsieh, C.S., Lee, S.Y., Chen, C.L. J. Pathol. (2004) [Pubmed]
  5. Axonal dystrophy in the gracile nucleus in congenital biliary atresia and cystic fibrosis (mucoviscidosis): beneficial effect of vitamin E therapy. Sung, J.H., Park, S.H., Mastri, A.R., Warwick, W.J. J. Neuropathol. Exp. Neurol. (1980) [Pubmed]
  6. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. Shivakumar, P., Campbell, K.M., Sabla, G.E., Miethke, A., Tiao, G., McNeal, M.M., Ward, R.L., Bezerra, J.A. J. Clin. Invest. (2004) [Pubmed]
  7. Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease. Barton, E.S., Youree, B.E., Ebert, D.H., Forrest, J.C., Connolly, J.L., Valyi-Nagy, T., Washington, K., Wetzel, J.D., Dermody, T.S. J. Clin. Invest. (2003) [Pubmed]
  8. Analysis of the biliary transcriptome in experimental biliary atresia. Carvalho, E., Liu, C., Shivakumar, P., Sabla, G., Aronow, B., Bezerra, J.A. Gastroenterology (2005) [Pubmed]
  9. Acute parvovirus B19 infection associated with fulminant hepatitis of favourable prognosis in young children. Sokal, E.M., Melchior, M., Cornu, C., Vandenbroucke, A.T., Buts, J.P., Cohen, B.J., Burtonboy, G. Lancet (1998) [Pubmed]
  10. Increased urinary dipeptidyl peptidase IV activity in extrahepatic biliary atresia. Rákoczi, G., Takács, L., Jakabfi, P., Kunos, I., Selmeci, L., Gyuris, T., Péterfy, M., Verebély, T., Perner, F. Lancet (1995) [Pubmed]
  11. Ursodeoxycholic acid in biliary atresia. Nittono, H., Tokita, A., Hayashi, M., Nakatsu, N., Obinata, K., Watanabe, T., Yamashiro, Y., Yabuta, K., Miyano, T. Lancet (1988) [Pubmed]
  12. Liver levels of vitamin A and cellular retinol-binding protein for patients with biliary atresia. Ong, D.E., Amédée-Manesme, O. Hepatology (1987) [Pubmed]
  13. Spinocerebellar degeneration secondary to chronic intestinal malabsorption: a vitamin E deficiency syndrome. Harding, A.E., Muller, D.P., Thomas, P.K., Willison, H.J. Ann. Neurol. (1982) [Pubmed]
  14. Neonatal cholestatic conditions requiring surgical reconstruction. Ryckman, F.C., Noseworthy, J. Semin. Liver Dis. (1987) [Pubmed]
  15. Pharmacokinetics of bupivacaine after continuous epidural infusion in infants with and without biliary atresia. Meunier, J.F., Goujard, E., Dubousset, A.M., Samii, K., Mazoit, J.X. Anesthesiology (2001) [Pubmed]
  16. 25-Hydroxycholecalciferol inthe management of rickets associated with extrahepatic biliary atresia. Daum, F., Rosen, J.F., Roginsky, M., Cohen, M.I., Finberg, L. J. Pediatr. (1976) [Pubmed]
  17. Lack of correlation between infection with reovirus 3 and extrahepatic biliary atresia or neonatal hepatitis. Brown, W.R., Sokol, R.J., Levin, M.J., Silverman, A., Tamaru, T., Lilly, J.R., Hall, R.J., Cheney, M. J. Pediatr. (1988) [Pubmed]
  18. The developing human biliary system at the porta hepatis level between 29 days and 8 weeks of gestation: a way to understanding biliary atresia. Part 1. Tan, C.E., Moscoso, G.J. Pathol. Int. (1994) [Pubmed]
  19. Increased expression of intercellular adhesion molecules in biliary atresia. Dillon, P., Belchis, D., Tracy, T., Cilley, R., Hafer, L., Krummel, T. Am. J. Pathol. (1994) [Pubmed]
  20. RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. Tsuei, D.J., Hsu, H.C., Lee, P.H., Jeng, Y.M., Pu, Y.S., Chen, C.N., Lee, Y.C., Chou, W.C., Chang, C.J., Ni, Y.H., Chang, M.H. Oncogene (2004) [Pubmed]
  21. In situ expression of fibrogenic growth factors and their receptors in biliary atresia: comparison between early and late stages. Faiz Kabir Uddin Ahmed, A., Ohtani, H., Nio, M., Funaki, N., Iwami, D., Kumagai, S., Sato, E., Nagura, H., Ohi, R. J. Pathol. (2000) [Pubmed]
  22. Erythrocyte lipid alterations in pediatric cholestatic liver disease: spur cell anemia of infancy. Cynamon, H.A., Isenberg, J.N., Gustavson, L.P., Gourley, W.K. J. Pediatr. Gastroenterol. Nutr. (1985) [Pubmed]
  23. Matrilysin (MMP-7) is a major matrix metalloproteinase upregulated in biliary atresia-associated liver fibrosis. Huang, C.C., Chuang, J.H., Chou, M.H., Wu, C.L., Chen, C.M., Wang, C.C., Chen, Y.S., Chen, C.L., Tai, M.H. Mod. Pathol. (2005) [Pubmed]
  24. Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia. Tamatani, T., Kobayashi, H., Tezuka, K., Sakamoto, S., Suzuki, K., Nakanishi, T., Takigawa, M., Miyano, T. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  25. Promoter polymorphism of the CD14 endotoxin receptor gene is associated with biliary atresia and idiopathic neonatal cholestasis. Shih, H.H., Lin, T.M., Chuang, J.H., Eng, H.L., Juo, S.H., Huang, F.C., Chen, C.L., Chen, H.L. Pediatrics (2005) [Pubmed]
  26. Association of serum interleukin-8 levels with the degree of fibrosis in infants with chronic liver disease. Nobili, V., Marcellini, M., Giovannelli, L., Girolami, E., Muratori, F., Giannone, G., Devito, R., De Benedetti, F. J. Pediatr. Gastroenterol. Nutr. (2004) [Pubmed]
  27. Treatment with ursodeoxycholic acid renders children with biliary atresia suitable for liver transplantation. Ullrich, D., Rating, D., Schröter, W., Hanefeld, F., Bircher, J. Lancet (1987) [Pubmed]
  28. Outcome of orthotopic liver transplantation in patients with haemophilia. Gordon, F.H., Mistry, P.K., Sabin, C.A., Lee, C.A. Gut (1998) [Pubmed]
  29. Diagnosis of biliary atresia with radionuclide hepatobiliary imaging. Gerhold, J.P., Klingensmith, W.C., Kuni, C.C., Lilly, J.R., Silverman, A., Fritzberg, A.R., Nixt, T.L. Radiology. (1983) [Pubmed]
  30. Biliary atresia: feasibility of mangafodipir trisodium-enhanced MR cholangiography for evaluation. Ryeom, H.K., Choe, B.H., Kim, J.Y., Kwon, S., Ko, C.W., Kim, H.M., Lee, S.B., Kang, D.S. Radiology. (2005) [Pubmed]
  31. Manganese deposition in the globus pallidus in patients with biliary atresia. Ikeda, S., Yamaguchi, Y., Sera, Y., Ohshiro, H., Uchino, S., Yamashita, Y., Ogawa, M. Transplantation (2000) [Pubmed]
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