Disease relevance of MEBROFENIN

• CONCLUSION: Correlation of (99m)Tc-mebrofenin handling with liver morphology, function, and copper accumulation in LEC rats suggests that mebrofenin scintigraphy can be useful for noninvasively monitoring disease progression and therapeutic response in Wilson's disease [1].
• Although the data were obtained in an animal model of Wilson' disease, these biochemical parameters likely reflect liver damage in general, suggesting that there may be a role for mebrofenin scintigraphy in other chronic liver diseases as well [1].
• Multifocal uptake of Tc-99m mebrofenin in dilated liver ductules in a patient with cystic fibrosis [2].
• Mebrofenin scintigraphy confirmed the presence of a choledochal cyst in three of the four cases with that diagnosis [3].
• Focal liver uptake of Tc-99m mebrofenin in a patient with cavernous hemangioma [4].

High impact information on MEBROFENIN

• Scintigraphic findings were correlated with biliary mebrofenin excretion and residual organ counts and with hepatic copper content, histology, copper excretion capacity, and liver test results [1].
• Dynamic hepatobiliary imaging with 99mTc and mebrofenin, an iminodiacetic acid derivative, demonstrated no correlation with the presence or absence of acute rejection or with annexin V uptake [5].
• If no gallbladder was identified, a second dose of mebrofenin was given as necessary to have tracer in the biliary system [6].
• Functional studies showed a statistically significant lower LDH release and total tissue water content and a higher technetium-99m mebrofenin uptake for hepatocytes preserved in UW solution [7].
• All of these patients underwent abdominal ultrasonography and cholescintigraphy with technetium-99m mebrofenin [8].

Chemical compound and disease context of MEBROFENIN

• Technetium-99m mebrofenin hepatobillary excretory patterns were assessed in 36 infants with hyperbilirubinemia [9].

Biological context of MEBROFENIN

• Gastric emptying of each diet was measured by labelling the test meals with Technetium(99m) Mebrofenin and using a conventional gamma camera equipped with a high resolution, parallel hole collimator [10].
• METHODS: Two nuclear medicine physicians reviewed 36 Tc-99m mebrofenin hepatobiliary scans (31 patients) [11].
• The current study uses a novel oroenteric tube coupled with a specialized clinical protocol to examine the pharmacokinetics of 99mTechnetium (Tc-99m) mebrofenin, a compound that undergoes rapid hepatic uptake and extensive biliary excretion [12].
• The hepatic parenchymal cells extract mebrofenin from the blood by the same active transport mechanism as bilirubin [13].

Anatomical context of MEBROFENIN

• Sequential imaging was performed until gallbladder activity was identified or up to 90 min postinjection of mebrofenin [6].
• Similarly, functional studies of the preserved hepatocytes included LDH release, total tissue water content, and amount of 99m-technetium mebrofenin uptake [7].
• The role of 99mTc mebrofenin hepatobiliary scanning in predicting common bile duct stones in patients with gallstone disease [14].
• For canned dog food, mebrofenin had a 91% SPR for the water or gastric juice digestions, and 99mTc-Dowex had a %SPR of >99% [15].

Analytical, diagnostic and therapeutic context of MEBROFENIN

• HPLC method for determination of the purity of a mebrofenin-ligand for 99mTc-complexes [16].
• Mebrofenin scintigraphy is an important imaging technique in the diagnostic evaluation of infants with hyperbilrubinemia [9].
• Liver allograft recipients were evaluated with Tc-99m mebrofenin hepatobiliary scintigraphy within the first postoperative week and as required thereafter [17].
• Two hours after Tc-99m mebrofenin administration, the gallbladder was contracted with an intravenous infusion of cholecystokinin-8 [12].
• Nine donors underwent hepatobiliary scintigraphy with intravenous injection of Tc-99m mebrofenin 1 day before and during the first week after left liver lobectomy [18].

References