Disease relevance of Trichuriasis

• Those for mebendazole were 52 and 91.2 in trichuriasis and 37.5 and 89.7 in necatoriasis [1].
• Cortisone-induced immunotolerance to nematode infection in CBA/Ca mice. II. A model for human chronic trichuriasis [2].
• CONCLUSION: Because of the superiority of albendazole + ivermectin against both lymphatic filariasis and trichuriasis, this combination appears to be a suitable tool for the integrated or combined control of both public health problems [3].
• Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis [4].
• Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru [5].

High impact information on Trichuriasis

• INTERPRETATION: Symptomless trichuriasis impairs growth and albendazole or pyrantel may affect growth, independently of a therapeutic action on parasites [6].
• Although hemoglobin values tended to be slightly lower in Trichuris-infected children, there was no association between trichuriasis and serum iron or transferrin saturation values [7].
• CONCLUSIONS: There is an acute phase response in intense trichuriasis and a specific elevation of plasma fibronectin [8].
• We measured plasma concentrations of cortisol and aldosterone before and after administration of adrenocorticotropin (ACTH) in dogs with trichuriasis [9].
• In vivo neutralization experiments using anti-cytokine monoclonal antibodies show that critical cytokines are involved, with interferon-gamma playing an important role in the establishment of chronic trichuriasis and interleukin-4 in expulsion of the parasite from the gut [10].

Chemical compound and disease context of Trichuriasis

• Treatment of severe symptomatic trichuriasis observed with heavy worm burdens is not satisfactory with recommended doses of mebendazole, flubendazole and albendazole [11].
• 166 patients with trichuriasis have been treated at the Department of Tropical Diseases, Aurora Hospital, Helsinki, from January 1975 to October 1979 [12].
• Experiencw with bitoscanate in hookworm disease and trichuriasis in Mexico [13].
• Trichuriasis was the commonest helminthic infection and was associated with significantly lower serum vitamin A concentrations than in uninfected subjects [14].
• Diphetarsone is an arsenical used in the treatment of intestinal amoebiasis and trichuriasis [15].

Anatomical context of Trichuriasis

• The cytoplasmic granules were antigenic against trichinosis sera from humans and rats, and cross-reacted with sera from paragonimiasis, trichuriasis and gnathostomiasis patients [16].

References