Disease relevance of Trichinosis

• Sera from patients with echinococcosis, filariasis, paragonimiasis, clonorchiasis, trichinosis, amebiasis, and hepatitis and from healthy uninfected control individuals generally contained no detectable antibodies against this antigen [1].
• Sera samples were collected from patients with confirmed hydatidosis and trichinosis and with other parasitic diseases as well as from normal healthy individuals [2].
• Indirect fluorescent antibody test (IFAT) was performed on sections of Gnathostoma spinigerum advanced third-stage larva with gnathostomiasis, angiostrongyliasis, trichinosis, strongyloidiasis and cysticercosis sera [3].
• Cross-reactions were observed with sera from patients with cysticercosis, filariasis, toxocariasis, trichinosis, visceral larval migrans, and liver cirrhosis [4].
• The cuticle surface and stichocyte alpha 0- and alpha 1-granules reacted predominantly with sera from trichinosis and severe trichuriasis patients, and negligibly with the others [5].

High impact information on Trichinosis

• The corticosterone response to trichinosis fits the sterotyped reaction previously reported for several other bacterial, viral, and rickettsial infections [6].
• We suggest that neurologic complications of trichinosis should be treated by corticosteroids and flubendazole [7].
• Comparative efficacy of ketoconazole and mebendazole in experimental trichinosis [8].
• This study indicates that both ketoconazole and mebendazole should be considered in the treatment of trichinosis in humans [8].
• The immediate efficacy of thiabendazole and albendazole as therapy for trichinosis was comparable, but albendazole was better tolerated [9].

Chemical compound and disease context of Trichinosis

• The number of cases of trichinosis reported to Centers for Disease Control has declined steadily, with an average of only 44 cases per year from 1984 through 1988 [10].
• Effects on murine trichinosis of niridazole, a suppressant of cellular but not humoral immunological responses [11].
• Effect of cyclosporin A on trichinosis. A histochemical study [12].
• An investigation of North Atlantic whales for trichinosis [13].
• Muscle changes in experimental trichinosis before and after albendazole therapy [14].

Biological context of Trichinosis

• After a common source outbreak of trichinosis in Bitburg, FRG, 107 patients, for whom time and source of infection were precisely known, were prospectively studied for a period of eight months in order to investigate the kinetics of the humoral immune response [15].

Anatomical context of Trichinosis

• The present work is concerned with study of the effects of praziquantel, thiabendazole, mebendazole, cyclophosphamide and cortisone on histopathology of the small intestine (during intestinal phase) and skeletal muscles (during muscular phase), in addition to T. lymphocytes count and serum IgG estimation in experimental trichinosis in albino rats [16].

Gene context of Trichinosis

• Intercellular adhesion molecule-2 (ICAM-2) in experimental trichinosis [17].
• Outbreak of trichinosis near Paris [18].
• METHODS: IFAT using frozen section of the purified Trichinella larvae as antigen was employed to detect anti-Trichinella antibodies in sera from mice infected with Trichinella spiralis and the patients with trichinosis [19].
• Role of anti-Trichinella spiralis antibodies and interferon-gamma in the protection against the enteral phase of experimental trichinosis [20].
• The effect of antioxidant preparation (antox) on the course and efficacy of treatment of trichinosis [21].

Analytical, diagnostic and therapeutic context of Trichinosis

• Comparable sensitivity and specificity of the standard ELISA and dot-ELISA were obtained when sera of 18 confirmed cases of trichinosis were screened [22].
• It was suggested that sera should be examined not before 1 month after infection to achieve maximum sensitivity for serodiagnosis of human trichinosis [23].

References